The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos

Nur, Gökhan; Güven, Aysel; Kiliçle, Pınar Aksu

doi:10.37212/jcnos.418660

Cited by 2 publications

(1 citation statement)

References 23 publications

(31 reference statements)

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“…Various studies have stated that CAPE is highly effective in protecting core cytosolic proteins, membrane lipids, and DNA against oxidative damage because of its antioxidant and free radical scavenging properties (21,(46)(47)(48). A handful of studies have shown that CAPE is effective in protecting the oxidant / antioxidant balance of the organism, in favor of antioxidants because it prevents oxidative stress in cells caused by cadmium toxicity (11,35).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study

Deveci

Nur

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et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels and increased their TSA, LDL, TOC, and OSI levels. The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

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Section: Discussionmentioning

confidence: 99%

The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study

Deveci

Nur

Kükürt

et al. 2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin

et al. 2023

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Alpha cypermethrin (α-CYP) is an insecticide, a member of the group of synthetic pyrethroid pesticides. This study aims to assess the histopathological and biochemical subacute effects of α-CYP on the renal tissues of 48 male Spraque–Dawley adult rats. In this study, the rats were divided into six groups: control, α-CYP (10 mg kg−1), α-CYP (20 mg kg−1), caffeic acid phenethyl ester (CAPE) (10 µmol kg−1), α-CYP + CAPE (10 mg kg−1), and α-CYP + CAPE (20 mg kg−1) groups. The percentage of weight gain was found to be dose-dependent on α-CYP in all groups. As a result of exposure, the normal histological structure of renal tissue was also observed in the control and CAPE groups, while glomerular atrophy and haemorrhage, enlargement of Bowman capsule, glomerular lobulation, and degeneration in distal and proximal tubules were noted in the α-CYP-treated groups with an increased frequency and severity in parallel with the dose increase. Although the severity and intensity of lesions decreased in the α-CYP + CAPE groups, they were statistically insignificant (p > 0.05). A decrease in the antioxidant parameter levels and an increase in oxidant parameters were observed in parallel with the negative effects of the antioxidant system in the α-CYP-treated groups. The groups exposed to CAPE in combination with α-CYP exhibited a therapeutic trend towards normalization in biochemical parameters due to the antioxidant character of CAPE. However, considering the statistical difference between the groups treated with α-CYP alone and CAPE alone, it was observed that the therapeutic features of those chemicals were not robust.

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The effects of CAPE on oxidative stress and histopathological values in rats treated with subacute dichlorvos

Abstract: Histopathological and biochemical responses to the oxidative stress induced by glyphosate-based herbicides in the rainbow trout (Oncorhynchus mykiss

Cited by 2 publications

References 23 publications

The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study

The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study

The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin

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