The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite

Gu, Sun-Ja; Sohn, Joo-Yeon; Lim, Hyun‐Chang; Um, Yoo-Jung; Jung, Ui‐Won; Kim, Chang Sung; Lee, Yong‐Keun; Choi, Seong-Ho

doi:10.5051/jkape.2009.39.3.321

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…These materials are grafted into defected sites and are covered with a membrane during the guided bone regeneration (GBR) procedure [ 1 , 13 ]. Spaces between particles promote cell invasion and angiogenesis, but also cause mechanical weakening [ 14 ]. Furthermore, when the shape of a defect is unfavorable or the size of a defect is large, the augmented site can easily collapse and the particle type graft material is often displaced or lost [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Spaces between particles promote cell invasion and angiogenesis, but also cause mechanical weakening [ 14 ]. Furthermore, when the shape of a defect is unfavorable or the size of a defect is large, the augmented site can easily collapse and the particle type graft material is often displaced or lost [ 14 , 15 , 16 , 17 , 18 ]. Therefore, various methods of preventing the escape of particle type bone graft materials have been suggested.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these problems, studies on the composite materials of organic and inorganic substances have been actively conducted to take advantage of the benefits of block bone and particle type bone graft materials [ 14 , 18 ]. Some of these studies involved introducing organic substances between bone graft particles to prevent particle loss and enhance handling properties.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

et al. 2017

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In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm3) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed.

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