The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats

Biochemical effects of various pesticides on sprayers of grape gardens

“…Wind drift during spraying may be a health risk in a number of cases (12). Therefore inhibition of RBC or serum cholinesterase activity is a biomarkers of organophosphorus and carbamate pesticide exposure (13)(14)(15)(16)(17). Tolerance to the cholinergic over stimulation may be observed following repeated exposure to cholinesterase inhibiting chemicals.…”

Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse

“…A substantial body of toxicology research is based on rat tissues extracted with Triton X-100 (e.g., Maxwell et al, 1987;Lassiter et al, 1998;Mortensen et al, 1998). It was therefore important to determine whether tissue BChE in this species shares the serum enzyme's insensitivity to Triton X-100.…”

Nimodipine Affects the Microcirculation and Modulates the Vascular Effects of Acetylcholinesterase Inhibition

“…Large amounts of available binding protein results in a faster soman disappearance from the blood. Blood flow through organs with binding capability is one of the more important factors that affect the soman detoxification (21). In our previous study (9) the detoxification of soman from rabbit blood was significantly increased during the first minute after administration in nimodipine pre-treated animals.…”