The effects of bicuculline and GABA on the superior cervical ganglion of the cat

Groat, William C. de; Lalley, Peter M.; Block, Martin L.

doi:10.1016/0006-8993(71)90473-2

Cited by 41 publications

(12 citation statements)

References 12 publications

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“…Furthermore, this depolarizing action ofNA can be mimicked by agents which increase the intracellular concentration of cyclic adenosine 3',5'-monophosphate (cyclic AMP) (Madison & Nicoll, 1986), as would be expected for a response mediated by a fl-receptor. f-Receptor-mediated depolarizations have also been reported in the superior cervical ganglion (De Groat & Volle, 1966;Haefely, 1969;Brown & Dunn, 1983).…”

Section: Discussionmentioning

confidence: 96%

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Madison¹,

Nicoll²

1986

The Journal of Physiology

372

189

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SUMMARY1. CA1 pyramidal neurones were studied in rat in vitro hippocampal slices using standard intracellular and single-electrode voltage-clamp recording techniques to examine the actions of noradrenaline (NA).2. NA had two different effects on the resting membrane potential of pyramidal neurones; either a hyperpolarization accompanied by a decrease in membrane input resistance, or less commonly, a depolarization accompanied by an increase in input resistance. In many cells, both effects, a hyperpolarization followed by a depolarization were observed. The depolarization was mediated by a noradrenergic f-receptor.The hyperpolarization was more difficult to characterize, but may result from a-receptor activation.3. NA reduced the amplitude and duration ofthe slow calcium-activated potassium after-hyperpolarization (a.h.p.) that follows depolarization-induced action potentials. This action of NA was mediated by ,l1-noradrenergic receptors.

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Section: Discussionmentioning

confidence: 96%

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Madison¹,

Nicoll²

1986

The Journal of Physiology

372

189

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“…They consist of cholinergic receptors of the muscarinic type which can be blocked by atropine (AM BACHE et aI., 1956;SCHAU-MANN, 1957;VOLLE, 1963), and of adrenergic receptors, which inhibit ganglionic transmission, and which can be either blocked or not by C(-adrenergic blockers (DE GROAT and VOLLE, 1966). The role of these ganglionic receptors in the physiologic process of ganglionic transmission is uncertain.…”

Section: Mode Of Action a Principles Of Ganglionic Transmissionmentioning

confidence: 98%

Ganglion-Blocking Drugs in Antihypertensive Therapy

Kreye¹

1977

Antihypertensive Agents

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“…At this time there also appeared a continuous firing of the efferent fibres which may be seen as a broadening of the base line in Fig. 3D noradrenaline, 10 ,ug/kg or y-aminobutyric acid, 0 1-0 5 mg/kg, which also reduce transmission through sympathetic ganglia (de Groat & Volle, 1966;de Groat, 1966). The late, but not the early reflex, was also observed when a branch of the contralateral pelvic nerve was stimulated (Fig.…”

Section: A Observations In Cats With An Intact Spinal Cordmentioning

confidence: 99%

Reflexes to sacral parasympathetic neurones concerned with micturition in the cat

Groat¹,

Ryall²

1969

The Journal of Physiology

256

129

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SUMMARY1. Reflexes to sacral parasympathetic neurones were studied by electrophysiological techniques in decerebrate, in chloralose-anaesthetized, and in chronic spinal cats.2. Excitatory reflexes from pelvic nerve and sacral somatic afferent nerve fibres were present before and after chronic transection of the spinal cord, but the latencies differed markedly. It was concluded that the longlatency reflexes observed when the spinal cord was intact involved longloop reflexes to the brain-stem. The weak, short-latency reflexes in the chronic spinal cat were never observed when the spinal cord was intact and could be due to reorganized spinal connexions. The short-latency reflexes are probably unimportant in normal micturition.3. Stimulation of afferent fibres in the pelvic or sacral somatic nerves produced short-latency inhibitory post-synaptic potentials (IPSPs) and inhibition of discharges in parasympathetic neurones. This inhibition was due to a spinal reflex. 4. A local reflex was demonstrated in the pelvic plexus. This was probably a cholinergic axon reflex, but the remote possibility that it was a local cholinergic reflex involving sensory neurones in the bladder wall has not been excluded.

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The effects of bicuculline and GABA on the superior cervical ganglion of the cat

Cited by 41 publications

References 12 publications

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.

Ganglion-Blocking Drugs in Antihypertensive Therapy

Reflexes to sacral parasympathetic neurones concerned with micturition in the cat

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