The Effects of Being Informed About Chemotherapy-Related Cognitive Symptoms With And Without Self-Affirmation on Perceived Cognitive Symptoms of Breast Cancer Patients: A Randomized Prospective, Longitudinal Study

Jacobs, Wendy Lynn; Schagen, Sanne B.; Brouwer, Susanne; Kieffer, Jacobien M.; Baas, Inge O.; Los, Maartje; Sonke, Gabe S.; Das, Enny

doi:10.1016/j.clbc.2022.03.001

Cited by 3 publications

(2 citation statements)

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“…In a longitudinal, randomized study among breast cancer patients that studied the effects of self-affirmation(N = 160), perceived cognitive symptoms also varied over time. While the MDASI scores initially increased from baseline to the end of chemotherapy, at six months after chemotherapy, scores on the symptom subscale gradually decreased to an average of 2.10 ± 2.01 for patients in the control arm [ 46 ]. These findings have been corroborated by longitudinal neuroimaging studies documenting decreased cognitive performance during chemotherapy, with partial recovery [ 47 ] or even increased performance years after treatment in some patients [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study

Naaktgeboren,

Koevoets,

Stuiver

et al. 2024

Breast Cancer Res Treat

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Purpose Cancer-related cognitive impairment (CRCI) following chemotherapy is commonly reported in breast cancer survivors, even years after treatment. Data from preclinical studies suggest that exercise during chemotherapy may prevent or diminish cognitive problems; however, clinical data are scarce. Methods This is a pragmatic follow-up study of two original randomized trials, which compares breast cancer patients randomized to exercise during chemotherapy to non-exercise controls 8.5 years post-treatment. Cognitive outcomes include an online neuropsychological test battery and self-reported cognitive complaints. Cognitive performance was compared to normative data and expressed as age-adjusted z-scores. Results A total of 143 patients participated in the online cognitive testing. Overall, cognitive performance was mildly impaired on some, but not all, cognitive domains, with no significant differences between groups. Clinically relevant cognitive impairment was present in 25% to 40% of all participants, regardless of study group. We observed no statistically significant effect of exercise, or being physically active during chemotherapy, on long-term cognitive performance or self-reported cognition, except for the task reaction time, which favored the control group (β = -2.04, 95% confidence interval: -38.48; -2.38). We observed no significant association between self-reported higher physical activity levels during chemotherapy or at follow-up and better cognitive outcomes. Conclusion In this pragmatic follow-up study, exercising and being overall more physically active during or after adjuvant chemotherapy for breast cancer was not associated with better tested or self-reported cognitive functioning, on average, 8.5 years after treatment. Future prospective studies are needed to document the complex relationship between exercise and CRCI in cancer survivors.

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Section: Discussionmentioning

confidence: 99%

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study

Naaktgeboren,

Koevoets,

Stuiver

et al. 2024

Breast Cancer Res Treat

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“…Pengobatan kemoterapi terdiri dari beberapa siklus, serta termasuk pengobatan yang jangka panjang. Apabila pasien kanker payudara dalam pengalaman pertamanya dalam menjalani kemoterapi dan mendapatkan pengalaman yang tidak menyenangkan, maka hal tersebut dapat mempengaruhi tingkat kecemasan dan kenyamanan pasien dalam menjalani pengobatan (Battisti et al, 2021) Pasien yang pernah menjalani pengobatan kemoterapi sebelumnya beresiko mengalami efek samping dibandingkan dengan yang belum pernah menjalani kemoterapi (Jacobs et al, 2022). Hasil penelitian (Juwita et al, 2018), bahwa siklus kemoterapi pasien kanker payudara dikelompokkan menjadi kategori yang menjalani siklus 1 sampai siklus 6.…”

Section: Siklus Kemoterapiunclassified

Gambaran Karakteristik Pasien Kanker Payudara Yang Menjalani Kemoterapi

Utami

Malini²,

Sarfika³

2022

REAL in Nursing Journal

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Background: The development of breast cancer cases, currently worldwide has become a major health problem among non-communicable diseases. In the healing process, chemotherapy is the main choice in the treatment of breast cancer. This study aims to describe the characteristics of breast cancer undergoing chemotherapy at two hospitals in the city of Padang. Methods: This type of research is cross sectional with a descriptive approach. Results: The results of the study showed the characteristics of breast cancer patients undergoing chemotherapy with an age range of 46-55 years, low education level, stage II cancer and second cycle of chemotherapy. Conclusion: Breast cancer patients undergoing chemotherapy at two government hospitals in Padang City are mostly elderly, low grade, stage 2 cancer, and 2nd home cycle. Suggestion: it is expected that health workers will provide education and counseling about early detection of breast cancer to reduce patients who come to the hospital with an advanced stage. Keywords: Breast Cancer, Chemotherapy, Breast Cancer Stage

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Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: Results of a pragmatic follow-up study

Naaktgeboren

Koevoets

Stuiver

et al. 2023

Preprint

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Purpose Cancer-related cognitive impairment (CRCI) following chemotherapy is commonly reported in breast cancer survivors, even years after treatment. Data from preclinical studies suggest that exercise during chemotherapy may prevent or diminish cognitive problems; however, clinical data are scarce. Methods This is a pragmatic follow-up study of two original randomized trials, which compares breast cancer patients randomized to exercise during chemotherapy to non-exercise controls 8.5 years post-treatment. Cognitive outcomes include an online neuropsychological test battery and self-reported cognitive complaints. Cognitive performance was compared to normative data and expressed as age-adjusted z-scores. Results A total of 143 patients participated in the online cognitive testing. Overall, cognitive performance was mildly impaired on some, but not all, cognitive domains, with no significant differences between groups. Clinically relevant cognitive impairment was present in 25% to 40% of all participants, regardless of study group. We observed no statistically significant effect of exercise, or being physically active during chemotherapy, on long-term cognitive performance or self-reported cognition, except for the task reaction time, which favored the control group (β=-2.04, 95% confidence interval: -38.48; -2.38). We observed no significant association between self-reported higher physical activity levels during chemotherapy or at follow-up and better cognitive outcomes. Conclusion In this pragmatic follow-up study, exercising and being overall more physically active during or after adjuvant chemotherapy for breast cancer did not yield better tested or self-reported cognitive functioning, on average, 8.5 years after treatment. Future prospective studies are needed to document the complex relationship between exercise and CRCI in cancer survivors.

show abstract

The Effects of Being Informed About Chemotherapy-Related Cognitive Symptoms With And Without Self-Affirmation on Perceived Cognitive Symptoms of Breast Cancer Patients: A Randomized Prospective, Longitudinal Study

Cited by 3 publications

References 84 publications

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: results of a pragmatic follow-up study

Gambaran Karakteristik Pasien Kanker Payudara Yang Menjalani Kemoterapi

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition: Results of a pragmatic follow-up study

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