The Effects of Baicalin on Myoglobinuric Acute Renal Failure in Rats

Yavuz, Özlem; Aydoğdu, Nurettin; Taştekin, Ebru; Süt, Necdet

doi:10.4274/balkanmedj.2017.0040

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…[41] Results of this study are in accordance with the previous studies. [42][43][44] conclusIon C. lanatus seed showed promising preventive effect against GL-induced ARF in this investigation, substantiating its ethnomedicinal use.…”

Section: Discussionsupporting

confidence: 72%

Amelioration of Rhabdomyolysis-Induced Myoglobinuric Acute Renal Failure by Citrullus lanatus Seeds

Patil¹,

Tiwari²,

Amrutkar³

2022

APJHS

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Citrullus lanatus (Thunb.) (Cucerbitaceae) is a trailing annual herb native to India, Nigeria, and Africa, commonly known as Matsum and Nakai. It thrives in all tropical, subtropical, and warm temperate areas with hot summers. In India, seeds have long been used to treat hypotensive and diuretic effects, as well as kidney stones and urinary passages. This study looked at the effects of a methanol extract of C. lanatus seeds (MCL) on rhabdomyolysis-induced myoglobinuric acute renal failure (ARF) in Wistar rats. Five groups (n = 5) of male Albino Wistar rats weighing 150–200 g were formed. A single intramuscular injection of glycerol (GL) (8 ml/kg) was used to induce ARF. Following GL injection, all animals were sacrificed and blood was collected. Renal function tests utilizing blood urea nitrogen (BUN) and creatinine were performed on freshly separated serum. The right kidney was stored in 10% buffered formalin for histological sectioning, and the amount of lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) activity were all measured. The data were analyzed using a one-way ANOVA and Dunnett’s test. *P > 0.05 was considered statistically significant. Animals pre-treated with MCL (100 and 300 mg kg-1, p.o.) for 7 days before GL dramatically altered and restored serum creatinine, BUN, creatinine clearance, urea clearance, and renal morphology in comparison to the GL-treated group. Oxidative stress markers such as lipid peroxidation, SOD, CAT, and GSH were also dramatically improved. The findings of this study suggest that C. lanatus seed has a possible anti-GL-induced ARF effect, verifying its ethnomedicinal use.

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Section: Discussionsupporting

confidence: 72%

Amelioration of Rhabdomyolysis-Induced Myoglobinuric Acute Renal Failure by Citrullus lanatus Seeds

Patil¹,

Tiwari²,

Amrutkar³

2022

APJHS

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“…The staining intensity was graded as 0 (negative), 1 (mild), 2 (moderate), and 3 (strong). Two values were multiplied to obtain an immunoreactivity score of 0-300, as described in our previous study (17).…”

Section: Methodsmentioning

confidence: 99%

The Effects of Irisin on L-Name Induced Hypertension in Rats

Aydoğdu¹,

Yavuz²,

Taştekin³

et al. 2019

Balkan Med J

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Background: The cause of about 95% of hypertension, an important public health problem, is unknown. Intensive studies are underway to understand the physiopathology of hypertension. Irisin, a newly discovered hormone, has been reported to dilate vascular smooth muscle and lower blood pressure acutely. Aims: To investigate the effects of chronic irisin treatment on blood pressure and renal functions in a hypertension model established by nitric oxide synthase inhibition by treatment with Nω-nitro-L-arginine methyl ester hydrochloride. Study Design: Animal experimentation. Methods: Male Sprague−Dawley rats were divided into four groups (n=8). Control and irisin groups received an intravenous saline injection, hypertension and hypertension + irisin (hypertension + irisin) groups received 1.5 mg/100 g Nω-nitro-L-arginine methyl ester hydrochloride. Nω-nitro-L-arginine methyl ester hydrochloride (150 mg/L) was added to the drinking water of rats in groups hypertension and hypertension + irisin for three weeks. In the second week of the experiment, irisin (50 nmol/day) was given to rats in groups irisin and hypertension + irisin, and saline was administered to rats in groups control and hypertension for two weeks through subcutaneously placed osmotic minipumps. Blood pressure was measured by the tail-cuff plethysmography method. On the twenty-first day of the experiment, 24-hour urine, blood, and both kidneys of the rats were collected. Results: The hypertension group had elevated systolic, diastolic, and mean arterial blood pressure values compared with the control group, with decreased glutathione levels in tissue and serum, but an increase in serum oxidized glutathione level (p<0.05). Histopathologically, increased tubular injury, cast formation, glomerular sclerosis, and peritubular fibrosis levels were observed (p<0.05). Irisin treatment did not cause any significant change in blood pressure, renal functions, and injury scores. However, renal nitric oxide levels significantly increased, and endothelial nitric oxide synthase immunoreactivity was determined to be reduced (p<0.05). Conclusion: Treatment with chronic irisin at a physiological dose does not reduce blood pressure in an experimental model of hypertension. In different models of experimental hypertension, the effects of irisin administration at different doses and at different periods should be thoroughly investigated.

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