The Effects of Ascorbic Acid and Oxiracetam on Scopolamine-Induced Amnesia in a Habituation Test in Aged Mice

Aqueous extracts of FBD, a Chinese herb formula composed ofPoria cocos, Atractylodes macrocephala,andAngelica sinensisreverse scopolamine induced memory deficit in ICR mice

“…Our results indicated that pretreatment with FBD extracts offered protection against scopolamine induced learning acquisition deficit and spatial memory deficit in ICR mice, because FBD extracts elongated latency and reduced the errors in the stepthrough test, as well as shortened escape latency and lessened the errors in the water maze test (Figures 1 and 2), in harmony with other studies (Bejar et al, 1999;de Angelis & Furlan, 1995).…”

Ascorbic Acid: a Promising Memory-Enhancer in Mice

“…Each group comprised of a minimum of 5 animals. In the present investigation, the dose selection was based on our pilot study and earlier reports (5).…”

“…However, there are conflicting reports regarding the usefulness of vitamin C in the treatment of dementia. Vitamin C did not increase the mental efficiency of human beings tested for their alertness, concentration, and mood (4) on the one hand, whereas ascorbic acid administered alone or in combination with oxiracetam prevented scopolamine-induced amnesia on the other hand when mice were subjected to the habituation test (5). Neurochemical analysis of Alzheimer's disease has revealed that there is a marked reduction in acetylcholine content of the cortical and hippocampal regions of human brain.…”

Fermented milk of Lactobacillus helveticus IDCC3801 reduces beta-amyloid and attenuates memory deficit

“…It is well known that scopolamine, muscarinic receptor blocker, interferes with memory and cognitive function in animal models (Kopelman & Corn, 1988). The scopolamine-induced amnesia model has widely been used in the study field for drug development with potential therapeutic values in dementia ( Bejar et al, 1999;de Angelis & Furlan, 1995;Hiramatsu et al, 1998;Rubaj et al, 2003). The Moris water maze is extensively applied to test spatial learning and memory, especially related to cholinergic hippocampal function (D'Hooge & De Deyn, 2001;Gage & Bjorklund, 1986).…”