Aqueous extracts of FBD, a Chinese herb formula composed of<i>Poria cocos, Atractylodes macrocephala,</i>and<i>Angelica sinensis</i>reverse scopolamine induced memory deficit in ICR mice

Lin, Zhihong; Xiao, Zhibin; Zhu, Daling; Yan, Yi–Dan; Yu, Boyang; Wang, Qiujuan

doi:10.1080/13880200902758816

Cited by 20 publications

(7 citation statements)

References 25 publications

(35 reference statements)

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“…Although several studies failed to show the superior effects of CHM on cognitive function and ADL compared with conventional drugs, these results may be interpreted as the equivalent effects of CHM with conventional drug therapies 15, 17, 20, 36, 46. In the Chinese medical theories, the multi-herbs of CHM may have synergetic effects on to regulate the Amyloid beta and calcium disorder, as accumulating Amyloid beta and calcium disorder are associated with the physiology pathology of AD 47, 48, 49. For example, CHM (i.e., Yizhi formula) can reduce the Aβ aggregation and calcium ion activity, and further improve the memory abilities in Aβ-induced mice 50, 51.…”

Section: Discussionmentioning

confidence: 96%

Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis

Zhang

Noh

Song

2019

Integrative Medicine Research

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Background This systematic review was performed to investigate the effects of Chinese herbal nedicine (CHM) on cognitive function and activity of daily living (ADL) in individuals with Alzheimer's disease. Methods Five electronic databases (Medline, Embase, Cinahl, PsycArticles, and CNKI) were searched from inception to January 2019. Randomized controlled trials (RCTs) assessing the effect of CHM on cognition and activity of daily living in adults with Alzheimer's disease were included. We pooled the effects size using the Comprehensive Meta-Analysis Software. Cochrane risk of bias tool was used to evaluate the study quality. Results Twenty-five RCTs (1855 individuals with AD) were included in this review. Overall findings of this meta-analysis indicated that CHM improved the cognitive function (SMD = 0.66, 95% CI [0.44, 0.89], I 2 = 77.9%, p < 0.001) and ADL (SMD = 0.38, 95% CI [0.25, 0.49], I 2 = 35.3%, p < 0.001) compared with conventional drugs. No publication biases were observed on both cognitive function and ADL. Conclusion CHM may have potential effects for improving cognitive function and ADL for individuals with AD compared with conventional drug therapies. However, the evidence is limited because of high risk of bias of the included trials.

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Section: Discussionmentioning

confidence: 96%

Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis

Zhang

Noh

Song

2019

Integrative Medicine Research

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“…Poria 's cognitive action has been ascribed to AChE inhibition and bidirectional regulation of cytosolic free calcium [43, 44]. …”

Section: Chinese Materia Medica For the Treatment Of Admentioning

confidence: 99%

“…There is suggestive evidence that Poria could enhance hippocampal LTP and improve scopolamine-induced spatial memory impairment in rats. Poria 's cognitive action has been ascribed to AChE inhibition and bidirectional regulation of cytosolic free calcium [ 43 , 44 ].…”

Section: Chinese Materia Medica For the Treatment Of Admentioning

confidence: 99%

History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer′s Disease

Liu

Kong

Yuan

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, herbal medicines, which are used to treat Alzheimer's disease (AD) in China based on TCM or modern pharmacological theories have attracted considerable attention. In this paper, we discuss etiology and pathogenesis of AD, TCM therapy, and herbal extracts for the treatment of AD. There is evidence to suggest that TCM therapy may offer certain complementary cognitive benefits for the treatment of AD. Chinese herb may have advantages with multiple target regulation compared with the single-target antagonist in view of TCM.

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“…The edible W. cocos sclerotium has been called “Indian bread” or “tuckahoe” in North America [ 2 ]. Furthermore, fuling has been used as a crude drug as a stomachic, diuretic, and sedative in traditional Chinese and Japanese herbal medicine [ 3 , 4 ]. Fuling is also widely used as a supplement in multiple wines, nutraceuticals, functional foods, cosmetics, and tea to improve the quality [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Analysis of Sterol O-Acyltransferase Involved in the Biosynthetic Pathway of Pachymic Acid in Wolfiporia cocos

et al. 2021

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Pachymic acid from Wolfiporia cocos possesses important medicinal values including anti-bacterial, anti-inflammatory, anti-viral, invigorating, anti-rejection, anti-tumor, and antioxidant activities. However, little is known about the biosynthetic pathway from lanostane to pachymic acid. In particular, the associated genes in the biosynthetic pathway have not been characterized, which limits the high-efficiency obtaining and application of pachymic acid. To characterize the synthetic pathway and genes involved in pachymic acid synthesis, in this study, we identified 11 triterpenoids in W. cocos using liquid chromatography tandem mass spectrometry (LC-MS/MS), and inferred the putative biosynthetic pathway from lanostane to pachymic acid based on analyzing the chemical structure of triterpenoids and the transcriptome data. In addition, we identified a key gene in the biosynthetic pathway encoding W. cocos sterol O-acyltransferase (WcSOAT), which catalyzes tumolusic acid to pachymic acid. The results show that silence of WcSOAT gene in W. cocos strain led to reduction of pachymic acid production, whereas overexpression of this gene increased pachymic acid production, indicating that WcSOAT is involved in pachymic acid synthesis in W. cocos and the biosynthesis of W. cocos pachymic acid is closely dependent on the expression of WcSOAT gene. In summary, the biosynthetic pathway of pachymic acid and the associated genes complement our knowledge on the biosynthesis of W. cocos pachymic acid and other triterpenoids, and also provides a reference for target genes modification for exploring high-efficiency obtaining of active components.

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Aqueous extracts of FBD, a Chinese herb formula composed ofPoria cocos, Atractylodes macrocephala,andAngelica sinensisreverse scopolamine induced memory deficit in ICR mice

Cited by 20 publications

References 25 publications

Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis

Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis

History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer′s Disease

Functional Analysis of Sterol O-Acyltransferase Involved in the Biosynthetic Pathway of Pachymic Acid in Wolfiporia cocos

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