The Effects of Aqueous Extract of Celery Leaves (Apium Gravelens) on the Delivery Rate, Sexual Ratio, and Litter Number of the Female Rats

Bazafkan, Mohammad Hassan; Hardani, Ameneh; Zadeh, Mohammad Reza Afzal; Zargar, Ashraf Amir; Moradi, Najme; Jalali, Nasrin

doi:10.17795/jjhr-23221

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Intraperitoneal injection of acetic acid can cause acute inflammation of the peritoneum ( 32 ). It appears that mediators such as bradykinin, serotonin, histamine, substance P, and prostaglandin, play a role in this model ( 8 , 10 , 14 , 15 ). It is justifiable that all of these mediators are associated with the stimulation of peripheral nociceptive neurons ( 31 ).…”

Section: Discussionmentioning

confidence: 78%

“…There is also increasing evidence to suggest that the prescription of medicinal plants to treat pain and inflammation is prevalent in traditional medicine ( 8 - 10 ), although the origin and structure of many such plants remain unknown. Therefore, obtaining information regarding their pharmaceutical effects can be considered a logical research approach in order to discover new drugs ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

2016

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Background:The drive toward the use of medicinal plants has been increasing in recent years. They have few side effects and a large variety of efficient components.Objectives:This study was designed to investigate the analgesic effects of hydroalcoholic Rhus coriaria leaf extract (HRCLE) in a rat model.Materials and Methods:A total of 42 adult male rats were divided into seven groups: a control group (the animals did not receive any drug), three HRCLE groups, (receiving 80, 100, and 300 mg/kg, intraperitoneally [ip]), a morphine group (1 mg/kg, ip) an aspirin group (1 mg/kg, ip), and a group that received 300 mg/kg of HRCLE plus naloxone (1 mg/kg, ip). The analgesic effects of HRCLE were assessed via writhing, tail flick, and formalin tests, and the data obtained were compared with the control group using one-way analysis of variance and Tukey post hoc tests.Results:HRCLE signiﬁcantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at the 100 mg/kg dose (in the chronic phase) and at the 300 mg/kg dose (in the chronic-acute phase) in the formalin test. Interestingly, the greatest effect was observed at the 300 mg/kg HRCLE dose in the tail flick test. Simultaneous utilization of naloxone and HRCLE inhibited the anti-nociceptive effect of the extract in all tests. It is worth mentioning that aspirin and morphine revealed anti-nociceptive effects in all tests.Conclusions:Our findings suggest that the analgesic effect of HRCLE may be mediated via both peripheral and central mechanisms. The presence of flavonoids might be responsible for the anti-nociceptive activity of this plant.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

2016

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Perinatal exposure to omega-3 fatty acid imbalance leads to early behavioral alterations in rat pups

Colucci

Castro

Peloso

et al. 2020

Behavioural Brain Research

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The effect of celery (Apium graveolens L.) on fertility: A systematic review

Kooti

Moradi

Peyro

et al. 2017

Journal of Complementary and Integrative Medicine

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Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L.", "fertility", "reproductive system", "sperm", "testis", "delivery", "sexual hormone", "LH", "FSH", "testosterone", "semen", "male", and "female". Out of 238 collected articles (published in the period 1995 to 2015), 222 were excluded due to non-relevance and lack of access to the original article. Results The notable points were the different results seen by different researchers during different treatment periods or at different doses. Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant. Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis. In this regard, the doses used and the treatment time while using the plant must be accurately investigated. Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.

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The Effects of Aqueous Extract of Celery Leaves (Apium Gravelens) on the Delivery Rate, Sexual Ratio, and Litter Number of the Female Rats

Cited by 3 publications

References 8 publications

Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain in Male Rats

Perinatal exposure to omega-3 fatty acid imbalance leads to early behavioral alterations in rat pups

The effect of celery (Apium graveolens L.) on fertility: A systematic review

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