Perinatal exposure to omega-3 fatty acid imbalance leads to early behavioral alterations in rat pups

Colucci, Paola; Castro, Valentina De; Peloso, Andréa; Splendori, Marta; Trezza, Viviana; Campolongo, Patrizia

doi:10.1016/j.bbr.2020.112723

Cited by 5 publications

(3 citation statements)

References 86 publications

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“…Maternal behavior was assessed daily in the colony room, from PND 2 to PND 13, by well-trained experimenters, who were blinded to experimental groups. The assessments occurred at regular intervals of 3 min in 3 sessions of 72 min each during the light phase (09:00 a.m., 01:00 p.m., 05:00 p.m.), as previously described by Colucci and colleagues [ 77 ]. Literature data indicate that maternal behavior is high during the light phase and declines during the dark phase of the light/dark cycle [ 78 , 79 ].…”

Section: Methodsmentioning

confidence: 99%

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats

Carbone

Buzzelli

Manduca

et al. 2023

IJMS

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Several studies have supported the association between maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of gestation and an increased susceptibility to the development of various psychiatric and neurological disorders, including autism and other neurodevelopmental disorders (NDDs), in the offspring. In the present work, we aimed to provide extensive characterization of the short- and long-term consequences of MIA in the offspring, both at the behavioral and immunological level. To this end, we exposed Wistar rat dams to Lipopolysaccharide and tested the infant, adolescent and adult offspring across several behavioral domains relevant to human psychopathological traits. Furthermore, we also measured plasmatic inflammatory markers both at adolescence and adulthood. Our results support the hypothesis of a deleterious impact of MIA on the neurobehavioral development of the offspring: we found deficits in the communicative, social and cognitive domains, together with stereotypic-like behaviors and an altered inflammatory profile at the systemic level. Although the precise mechanisms underlying the role of neuroinflammatory states in neurodevelopment need to be clarified, this study contributes to a better understanding of the impact of MIA on the risk of developing behavioral deficits and psychiatric illness in the offspring.

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Section: Methodsmentioning

confidence: 99%

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats

Carbone

Buzzelli

Manduca

et al. 2023

IJMS

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“…Experimental diets enriched in either LA (ω‐3–deficient diet) or ALA (ω‐3–enriched diet) decreased maternal care behaviors (e.g., nest building, arched, blanket, and passive nursing, licking, pup retrieval, breast grooming) whilst promoting non‐maternal behaviors (feeding, exploring, self‐grooming), and changed the pattern and subtypes of USVs of pups deprived of their mothers. Thus, long‐lasting behavioral disturbances ensued in the experimental offspring 99 …”

Section: Maternal Diet As a Risk Factor For Mental Disorders In Their...mentioning

confidence: 99%

“…deficient diet) or ALA (ω-3-enriched diet) decreased maternal care behaviors (e.g., nest building, arched, blanket, and passive nursing, licking, pup retrieval, breast grooming) whilst promoting non-maternal behaviors (feeding, exploring, self-grooming), and changed the pattern and subtypes of USVs of pups deprived of their mothers. Thus, longlasting behavioral disturbances ensued in the experimental offspring 99. 3.2.1 | Imbalanced ω-6: ω-3 PUFA diets impact brain lipid compositionExperimental models allow unprecedented analytical accuracy in determining PUFA composition of the developing brain at both prenatal and postnatal time-points.…”

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confidence: 99%

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Cinquina

Keimpema

Pollak

et al. 2023

J Neuroendocrinology

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Obesity is a key medical challenge of our time. The increasing number of children born to overweight or obese women is alarming. During pregnancy, the circulation of the mother and her fetus interact to maintain the uninterrupted availability of essential nutrients for fetal organ development. In doing so, the mother's dietary preference determines the amount and composition of nutrients reaching the fetus. In particular, the availability of polyunsaturated fatty acids (PUFAs), chiefly their ω‐3 and ω‐6 subclasses, can change when pregnant women choose a specific diet. Here, we provide a succinct overview of PUFA biochemistry, including exchange routes between ω‐3 and ω‐6 PUFAs, the phenotypes, and probable neurodevelopmental disease associations of offspring born to mothers consuming specific PUFAs, and their mechanistic study in experimental models to typify signaling pathways, transcriptional, and epigenetic mechanisms by which PUFAs can imprint long‐lasting modifications to brain structure and function. We emphasize that the ratio, rather than the amount of individual ω‐3 or ω‐6 PUFAs, might underpin physiologically correct cellular differentiation programs, be these for neurons or glia, during pregnancy. Thereupon, the PUFA‐driven programming of the brain is contextualized for childhood obesity, metabolic, and endocrine illnesses.

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Interesterified fat consumption since gestation decreases striatal dopaminergic targets levels and gdnf impairing locomotion of adult offspring

et al. 2021

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Perinatal exposure to omega-3 fatty acid imbalance leads to early behavioral alterations in rat pups

Cited by 5 publications

References 86 publications

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Interesterified fat consumption since gestation decreases striatal dopaminergic targets levels and gdnf impairing locomotion of adult offspring

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