The effects of apelin treatment on a rat model of type 2 diabetes

Akçılar, Raziye; Turgut, Sebahat; Caner, Vildan; Akcılar, Aydın; Ayada, Ceylan; Elmas, Levent; Özcan, Tuğrul

doi:10.1016/j.advms.2014.11.001

Cited by 27 publications

(13 citation statements)

References 47 publications

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“…According to the results of the present study the Apelin expression has been reported in cardiac muscle and it appears that Apelin plays an important role in the regulation of heart function and metabolism. In accordance with our findings, Akcılar et al (2015) has shown that diabetes induction resulted in an increasing of Apelin expression in cardiac muscle and aorta. The over expression of Apelin in cardiovascular tissues and ischemic cardiomyopathy has been recently reported (Atluri et al 2007).…”

Section: Figsupporting

confidence: 93%

Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet

Nazari

Moghimipour

Tabandeh

2016

Int J Pept Res Ther

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Apelin is a newly discovered peptide that its serum level increases in diabetic patients with cardiovascular dysfunction. Recent studies indicate the beneficial actions of betaine in reducing the cardiovascular and metabolic complications, however data related to its effect on adipocytokine expression is limited. The aim of this study was to evaluate the effect of betaine supplementation on Apelin gene expression in cardiac muscle and adipose tissue of insulin resistance, diabetic rats fed by a high calorie diet. To induce insulin resistance rats were fed with high fat/high carbohydrate diet for five weeks and then 30 mg/kg STZ was injected intraperitoneally. After confirming of diabetes incidence (serum glucose above 7.5 mmol/l) the animals were treated with 1 % betaine in drinking water for 28 days. At days 14 and 28 after treatment, animals were euthanized and Apelin gene expression was evaluated by real time PCR and western blot in heart and adipose tissues. Serum levels of insulin, Apelin and glucose and HOMA-IR were also measured. Our results showed that feeding of rats by a high calorie diets caused insulin resistance, which was manifested by elevated plasma insulin, glucose and Apelin levels and also HOMA-IR. Apelin gene expression in heart and adipose tissues were significantly increased simultaneously with the progression of diabetes. Betaine supplementation decreased serum Apelin and down regulated Apelin expression in adipose tissue and cardiac muscle, particularly at day 28 of treatment. We concluded that betaine might improve metabolic and cardiovascular complications in diabetic patients by regulation of Apelin expression and secretion.

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Section: Figsupporting

confidence: 93%

Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet

Nazari

Moghimipour

Tabandeh

2016

Int J Pept Res Ther

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“…Apelin is a recently discovered adipokine that has been reported to improve sugar intake and insulin sensitivity, to promote energy consumption, and to reduce blood pressure, while also being important in obesity-related metabolic disease [17, 43]. The secretion and expression of apelin, which is secreted from the heart, blood vessels, and white adipose tissue, are regulated by insulin; thus, apelin is closely related to metabolic syndrome and other disorders caused by diabetes or insulin resistance [44].…”

Section: Discussionmentioning

confidence: 99%

Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial

et al. 2019

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BackgroundThe risk for obesity-related diseases increases with the prevalence of obesity. In obesity, adipokines secreted from adipose tissue induce inflammation, causing adverse effects. Recently, adipokines such as apelin, visfatin, and chemerin have been studied. Long-term resistance training improves health in middle-aged women by improving metabolic risk factors, body composition, and muscle strength. However, there is still a lack of evidence on the association of apelin concentration with different exercise types in middle-aged obese women This study aimed to investigate the effects of 8 weeks of aerobic and resistance exercises on apelin-12 and apelin-36 levels and thereby verify the effects of different exercise types in obese, middle-aged women.MethodsParticipants were middle-aged women aged 50–61 years, with no experience of systematic exercise in the last 6 months, and met the WHO obesity criteria for the Asia-Pacific region of waist circumference ≥ 80 cm and body fat percentage ≥ 30%. Subjects were selected and allocated to the aerobic exercise, resistance exercise, or no exercise group by block randomization. Body weight, body fat, and body mass index were measured by bioelectrical impedance analysis. Analysis of variance, the t-test, and Tukey’s post-hoc test were performed.ResultsA total of 24 participants were selected with eight participants in each group. Both aerobic and resistance exercises were effective in altering the physical composition, showing significant decreases in weight, waist circumference, BMI, and body fat. The aerobic and resistance exercise group showed a significant, positive change in apelin-12 levels.ConclusionsIn obese individuals, aerobic and resistance exercise were effective in improving obesity and reducing blood apelin-12 concentration, which is closely correlated with indicators of metabolic syndrome.Future research should focus on comparing the response of apelin to exercise in obese subjects treated with only dietary control and the response in the obese subjects of different ages and sex.Trial registrationNo. 1040917–201,506-BR-153-04, Clinical Research Information Service (CRIS), Republic of Korea (05 October 2018, retrospectively registered).

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“…In diabetic patients apelin-12 concertation was increased (Habchi et al, 2014 ), extending susceptibility to diabetes (Zheng et al, 2016 ), thus, examining plasma apelin level could be used as a method to predict the development of type 2 diabetes (Ma et al, 2014 ; Hu et al, 2016 ). Furthermore, an augmented level of apelin in rats suggests, that it has a strong anti-type 2 diabetic activity and acts as an insulin-sensitizing agent (Akcilar et al, 2015 ).…”

Section: Apelin In a Type 2 Diabetesmentioning

confidence: 99%

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

Wysocka

Pietraszek-Gremplewicz

2018

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Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by adipose tissue. Extensive tissue distribution of apelin and its receptor suggests, that it could be involved in many physiological processes including regulation of blood pressure, body fluid homeostasis, endocrine stress response, cardiac contractility, angiogenesis, and energy metabolism. Additionally, this peptide participates in pathological processes, such as heart failure, obesity, diabetes, and cancer. In this article, we review current knowledge about the role of apelin in organ and tissue pathologies. We also summarize the mechanisms by which apelin and its receptor mediate the regulation of physiological and pathological processes. Moreover, we put forward an indication of apelin as a biomarker predicting cardiac diseases and various types of cancer. A better understanding of the function of apelin and its receptor in pathologies might lead to the development of new medical compounds.

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The effects of apelin treatment on a rat model of type 2 diabetes

Cited by 27 publications

References 47 publications

Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet

Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet

Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

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