The effects of antioxidants on ocular blood flow in patients with glaucoma

Harris, Alon; Gross, Josh; Moore, Nicholas; Do, Thai; Huang, Amelia; Gama, Willy; Siesky, Brent

doi:10.1111/aos.13530

Cited by 42 publications

(27 citation statements)

References 29 publications

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“…Harris et al. () prospectively studied the effects of antioxidant dietary supplement therapy on ocular blood flow markers including OPP, retrobulbar blood flow and retinal capillary blood flow. After 1 month of antioxidant supplementation, the investigators reported on beneficial increases in these biomarkers compared to control subjects.…”

Section: Discussionmentioning

confidence: 99%

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Aref

Maleki

Tan

et al. 2019

Acta Ophthalmologica

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Purpose To test the hypothesis that visual field (VF) loss is associated with decreased retinal blood flow, oxygen delivery and metabolism, and with increased retinal oxygen extraction fraction (OEF) in glaucomatous individuals. Methods Glaucomatous subjects underwent automated perimetry, dual wavelength scanning laser ophthalmoscopy and Doppler optical coherence tomography imaging in order to measure mean deviation, central retinal arterial and venous diameter equivalents (CRAE and CRVE), oxygen saturation levels and total retinal blood flow (TRBF), respectively. Retinal oxygen delivery, metabolism and extraction fraction were derived from measurements of oxygen saturation and blood flow. Results Twenty eyes of 14 subjects were included in the study. Mean deviation was on average −13.76 ± 8.70 dB. Mean CRAE and CRVE were 126 ± 28 and 191 ± 35 μm, respectively. Mean TRBF and oxygen delivery were 34.3 ± 11.7 μl/min and 6.5 ± 2.6 μl O2/min, respectively. Mean oxygen metabolism and extraction fraction were 2.1 ± 0.94 μl O2/min and 0.34 ± 0.15, respectively. Visual field (VF) loss was associated with reduced CRAE and CRVE, TRBF and oxygen delivery and associated with increased OEF. Conclusion Combined measurements of retinal blood flow and oxygen saturation in glaucomatous individuals suggest VF loss is associated with impaired oxygen delivery and augmented OEF.

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Section: Discussionmentioning

confidence: 99%

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Aref

Maleki

Tan

et al. 2019

Acta Ophthalmologica

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“…In addition, exercise is known for its antioxidating ability (Thirupathi & de Souza ), while antioxidants were found to be associated with increase in OBF (Harris et al. ).…”

Section: Physical Exercise and Ocular Perfusionmentioning

confidence: 99%

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma‐related mental health

Zhu

Lai

Choy

et al. 2018

Acta Ophthalmologica

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The benefits of physical exercise on health and well-being have been studied in a wide range of systemic and ocular diseases, including glaucoma, a progressive optic neuropathy characterized by accelerated apoptosis of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and insufficient ocular perfusion have been postulated to be the two main theories in glaucoma development and progression. The effects of exercise in these two aspects have been demonstrated by numerous researches. A review in 2009 focusing on these two theories concluded that exercise results in transient IOP reduction but an inconsistent elevation in ocular perfusion. However, the majority of the studies had been conducted in healthy subjects. Over the past decade, technological advancement has brought forth new and more detailed evidence regarding the effects of exercise. Moreover, the neuroprotective effect of exercise by upregulation of neurotrophin and enhancement of mitochondrial function has been a focus of interest. Apart from visual impairment, the mental health issues in patients with glaucoma, which include anxiety and depression, should also be addressed. In this review, we mainly focus on publications from the recent years, so as to provide a comprehensive review on the impact of physical exercise on IOP, ocular perfusion, neuroprotection and mental health in patients with glaucoma.

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“…We observe in patients treated a decrease in significant additional of the IOP and an improvement from the PERG amplitude to 6, 9, and 12 months, and sensitivity foveola 12 months Harris et al [55] 45 patients treated, a group with the antioxidant and the other with placebo…”

Section: Ginkgo Biloba Extractmentioning

confidence: 50%

Glaucoma and Antioxidants: Review and Update

et al. 2020

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Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.

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The effects of antioxidants on ocular blood flow in patients with glaucoma

Abstract: One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.

Cited by 42 publications

References 29 publications

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma‐related mental health

Glaucoma and Antioxidants: Review and Update

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