Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Aref, Ahmad A.; Maleki, Shervin; Tan, Ou; Huang, David; Varma, Rohit; Shahidi, Mahnaz

doi:10.1111/aos.14120

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…In addition, Le et al50 reported an association between VF loss and peripapillary NFL thickness. The current study also showed a marginal correlation between decreased VF MD and decreased TRBF, consistent with findings reported by previous studies 9,23…”

Section: Discussionsupporting

confidence: 93%

“…Three MAP measurements were averaged per subject. Ocular perfusion pressure (OPP) was calculated as the difference between 2/3 MAP and IOP, as reported by previous studies 23,25…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, the vascular theory of glaucoma postulates that RGC loss is induced by an insufficient blood supply 4,20,21. This concept is supported by findings of reduced retinal blood flow (RBF) and its association with VF loss in glaucomatous eyes 9,22,23…”

mentioning

confidence: 90%

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Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma

Cano

Rahimi

et al. 2021

Journal of Glaucoma

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Precis: An association between macular vessel density (VD) and total retinal blood flow (TRBF) was demonstrated in subjects with primary open-angle glaucoma (POAG) and visual field (VF) loss. Purpose: The purpose of this study was to report relationships of macular VD metrics and TRBF in POAG. Materials and Methods: A total of 24 POAG and 19 healthy control subjects participated in the study. Subjects underwent optical coherence tomography and angiography for measurements of inner retinal thickness (IRT), VD, and spacing between large vessels (SLV) and small vessels (SSV). Doppler optical coherence tomography imaging was performed for TRBF measurement. In POAG subjects, automated perimetry was performed and VF loss expressed as mean deviation was measured. Results: Compared with the control group, POAG group had decreased VD, TRBF, IRT, and increased SLV (P<0.0001). Decreased VD (Pearson correlation, r=0.51; P<0.0001; N=43) and increased SLV (Spearman correlation, r s=−0.47; P=0.001) were correlated with decreased TRBF. Decreased VD and SSV (r≥0.39; P≤0.001; N=43) and increased SLV (r s=−0.71; P<0.0001) were associated with decreased IRT. Decreased VF mean deviation was correlated with decreased VD, SSV, IRT (r≥0.53; P≤0.001; N=24), and with increased SLV (r s=−0.84; P<0.0001). Conclusions: The finding of an association between macular VD and TRBF supports the role of vascular factors in the pathophysiology of POAG and potential conduct of future studies aimed at identifying multiple image-based vascular metrics for disease diagnosis.

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Section: Discussionsupporting

confidence: 93%

“…Three MAP measurements were averaged per subject. Ocular perfusion pressure (OPP) was calculated as the difference between 2/3 MAP and IOP, as reported by previous studies 23,25…”

Section: Methodsmentioning

confidence: 99%

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Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma

Cano

Rahimi

et al. 2021

Journal of Glaucoma

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“…The current study shows that retinal oxygen extraction is reduced in patients with glaucoma and is strongly correlated to the associated structural and functional damage. This is in keeping with a previous smaller-scale study in glaucoma patients [ 21 ]. Whereas several previous studies have shown that there is an association between ONH and/or retinal blood flow with glaucoma damage [ 22 , 23 , 24 , 25 , 26 , 27 ], our study links RGC damage to oxygen metabolism.…”

Section: Discussionsupporting

confidence: 92%

Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma

Garhöfer

Bata

Popa-Cherecheanu

et al. 2022

IJMS

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Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case–control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, p < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, p < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL p < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, p < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (p < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease.

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“…Retinal vessel oxygen saturation is an emerging biomarker with potential in risk stratification of diabetic retinopathy (DR) [1] and linking structural and functional damage in ocular disease [2,3]. Numerous studies have shown that retinal venous oxygen saturation is increased in DR [4] and is linked with its severity [5].…”

Section: Introductionmentioning

confidence: 99%

Oxygen saturation in retinal vessels and their correlation with endothelial microparticles in diabetes mellitus and/or cardiovascular disease

Heitmar

Blann

2022

Microvascular Research

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Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism

Cited by 11 publications

References 41 publications

Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma

Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma

Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma

Oxygen saturation in retinal vessels and their correlation with endothelial microparticles in diabetes mellitus and/or cardiovascular disease

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