The Effects of Antihypertensive Medications on the Physiological Response to Maximal Exercise Testing

Derman, Wayne; Sims, Rebecca; Noakes, T. D.

doi:10.1097/00005344-199200195-00015

Cited by 7 publications

(1 citation statement)

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“…Studies have shown varying effects—positive, negative, and neutral—depending on the medications and conditions under which the testing occurred. 6,7,11 …”

Section: Treating Haimentioning

confidence: 99%

Return to Activity at Altitude After High-Altitude Illness

deWeber

Scorza

2010

Sports Health

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Context:Sports and other activities at high altitude are popular, yet they pose the unique risk for high-altitude illness (HAI). Once those who have suffered from a HAI recover, they commonly desire or need to perform the same activity at altitude in the immediate or distant future.Evidence Acquisition:As based on key text references and peer-reviewed journal articles from a Medline search, this article reviews the pathophysiology and general treatment principles of HAI.Results:In addition to the type of HAI experienced and the current level of recovery, factors needing consideration in the return-to-play plan include physical activity requirements, flexibility of the activity schedule, and available medical equipment and facilities. Most important, adherence to prudent acclimatization protocols and gradual ascent recommendations (when above 3000 m, no more than 600-m net elevation gain per day, and 1 rest day every 1 to 2 ascent days) is powerful in its preventive value and thus strongly recommended. When these are not practical, prophylactic medications (acetazolamide, dexamethasone, salmeterol, nifedipine, or phosphodiesterase inhibitors, depending on the type of prior HAI) may be prescribed and can reduce the risk of illness. Athletes with HAI should be counseled that physical and mental performance may be adversely affected if activity at altitude continues before recovery is complete and that there is a risk of progression to a more serious HAI.Conclusion:With a thoughtful plan, most recurrent HAI in athletes can be prevented.

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“…Studies have shown varying effects—positive, negative, and neutral—depending on the medications and conditions under which the testing occurred. 6,7,11 …”

Section: Treating Haimentioning

confidence: 99%

Return to Activity at Altitude After High-Altitude Illness

deWeber

Scorza

2010

Sports Health

View full text Add to dashboard Cite

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Peptide synthesis through evolution

Tamura

Alexander

2004

Cellular and Molecular Life Sciences (CMLS)

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Ribosome-catalyzed peptide bond formation is a crucial function of all organisms. The ribosome is a ribonucleoprotein particle, with both RNA and protein components necessary for the various steps leading to protein biosynthesis. Evolutionary theory predicts an early environment devoid of complex biomolecules, and prebiotic peptide synthesis would have started in a simple way. A fundamental question regarding peptide synthesis is how the current ribosome-catalyzed reaction evolved from a primitive system. Here we look at both prebiotic and modern mechanisms of peptide bond formation and discuss recent experiments that aim to connect these activities. In particular, RNA can facilitate peptide bond formation by providing a template for activated amino acids to react and can catalyze a variety of functions that would have been necessary in a pre-protein world. Therefore, RNA may have facilitated the emergence of the current protein world from an RNA or even prebiotic world.

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