The effects of antihistamines on the semiology of febrile seizures

Takasu, Michihiko; Tsuji, Takeshi; Kurahashi, Hirokazu; Numoto, Shingo; Okumura, Akihisa

doi:10.1016/j.braindev.2018.07.005

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…22,23 Yonemoto et al and Takasu et al reported that optimal doses of either sedative or nonsedative antihistamines did not increase the febrile seizure duration, which was a median of 3 minutes and consistent with the present report. 22,23 These studies highlighted a need for the relationship between sedative antihistamines and febrile seizure duration to be re-examined. As supported by the results of this study, it appears that the usual dosage of sedative antihistamines does not prolong the duration of febrile seizure.…”

Section: Discussionsupporting

confidence: 91%

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

et al. 2020

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Some studies have shown that sedative antihistamines prolong febrile seizure duration. Although the collective evidence is still mixed, the Japanese Society of Child Neurology released guidelines in 2015 that contraindicated the use of sedative antihistamines in patients with febrile seizure. Focused on addressing limitations of previous studies, we conducted a cross-sectional study to evaluate the relationship between febrile seizure duration and the use of sedative antihistamines. Data were collected from patients who visited St. Luke's International Hospital due to febrile seizure between August 2013 and February 2016. Patients were divided into groups based on their prescribed medications: sedative antihistamine, nonsedative antihistamine, and no antihistamine. Seizure duration was the primary outcome and was examined using multivariate analyses. Of the 426 patients included, sedative antihistamines were administered to 24 patients. The median seizure duration was approximately 3 minutes in all three groups. There was no statistical difference in the bivariate (p = 0.422) or multivariate analyses (p = 0.544). Our results do not support the relationship between sedative antihistamine use and prolonged duration of febrile seizure. These results suggest that the use of antihistamines may be considered for patients with past history of febrile seizure, when appropriate.

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Section: Discussionsupporting

confidence: 91%

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

et al. 2020

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“…While the new-generation H 1 A has fewer side effects due to not passing the blood-brain barrier, it should be used with caution in younger children since this agent may disrupt the central anticonvulsant histaminergic system (21). Some studies have supported the use of optimal doses of H 1 antagonists in feverish children with allergic symptoms (13,18,24). Nevertheless, Daida et al (13) reported no significant association between antihistamine use and seizure duration, recommending the use of antihistamines for patients with a history of FS.…”

Section: Discussionmentioning

confidence: 99%

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Gorzin,

Hosseini,

Ghelichi-Ghojogh

et al. 2023

J Prev Epidemiol

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Introduction: Febrile seizures (FSs) are caused by the simultaneous consumption of first- and second-generation antihistamines, which prolong the process in some cases. Objectives: The present study aimed to evaluate the relationship between seizure susceptibility and type of antihistamines in patients with FS. Patients and Methods: This retrospective cohort study was conducted on 364 children with FS admitted to Taleghani Hospital in Gorgan, Iran in 2020. The subjects were selected via convenience sampling and divided into two groups of antihistamine and non-users based on their medical files. Data analysis was performed in SPSS16 using descriptive statistics and chi-square, independent t-test, Mann-Whitney U test, and relative risk. Results: The mean age of the patients was 22.77±14.91 months (6-60 months). 56.1% of the patients were male. Antihistamine was prescribed for 15.6% of the subjects, and the mean interval between fever onset and seizure was shorter in the antihistamine group (P=0.37). On the other hand, the mean seizure duration was significantly longer in the antihistamine group (P=0.049). The risk of a seizure lasting more than five minutes was 1.14 times higher in the first-generation antihistamine group compared to the second-generation group (P=0.078). Conclusion: According to the results, the patients with a history of antihistamine use during the febrile period experienced a significantly longer period of seizure, and a significant relationship was observed between the severity of seizures and antihistamine use. In addition, the mean seizure duration was longer in the first-generation antihistamine group. Therefore, the use of this class of drugs in this age range should be limited to the prescription of a specialist.

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“…39 Long-term use of daily anticonvulsants may be considered in selected patients with complex febrile seizures or recurrent febrile status epilepticus and multiple risk factors to develop epilepsy. 40 Intermittent benzodiazepine therapy during febrile illnesses has shown to be effective in preventing recurrences. A 3 to 5 days' course of oral benzodiazepines has been used.…”

Section: Treatment Of Simple Febrile Seizuresmentioning

confidence: 99%

Simple Febrile Seizures: A Benign Phenomena?

Andrade¹

2019

J Pediatr Epilepsy

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Febrile seizures are one of the most common neurological causes of visits to the emergency room. This article is a review of the current literature concerning the evaluation and treatment of children with febrile seizures. Longitudinal prospective studies such as the FEBSTAT study (consequences of prolonged febrile seizures in childhood) have contributed to elucidate the long-term outcome of patients with prolonged febrile seizures. Neurogenetic research also demonstrated the role of genetic mutations (mainly voltage-gated ion channels) in the etiology of febrile seizures. Most febrile seizures are self-limited events with low risk of injury or evolution into status epilepticus or sudden death. However, the use of rectal diazepam as acute abortive treatment for febrile seizures lasting 5 minutes or longer has gained acceptance as a first-line home intervention. Most patients with febrile seizures do not require extensive investigations, but the treatment involves a customized plan. Efforts should be directed to educate caregivers about prognosis and management of potential recurrences. In selected cases, appropriate use of preventive antiseizure medication may be a consideration.

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The effects of antihistamines on the semiology of febrile seizures

Cited by 4 publications

References 26 publications

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Simple Febrile Seizures: A Benign Phenomena?

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