Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

Abstract

Some studies have shown that sedative antihistamines prolong febrile seizure duration. Although the collective evidence is still mixed, the Japanese Society of Child Neurology released guidelines in 2015 that contraindicated the use of sedative antihistamines in patients with febrile seizure. Focused on addressing limitations of previous studies, we conducted a cross-sectional study to evaluate the relationship between febrile seizure duration and the use of sedative antihistamines. Data were collected from patients who visited St. Luke's International Hospital due to febrile seizure between August 2013 and February 2016. Patients were divided into groups based on their prescribed medications: sedative antihistamine, nonsedative antihistamine, and no antihistamine. Seizure duration was the primary outcome and was examined using multivariate analyses. Of the 426 patients included, sedative antihistamines were administered to 24 patients. The median seizure duration was approximately 3 minutes in all three groups. There was no statistical difference in the bivariate (p = 0.422) or multivariate analyses (p = 0.544). Our results do not support the relationship between sedative antihistamine use and prolonged duration of febrile seizure. These results suggest that the use of antihistamines may be considered for patients with past history of febrile seizure, when appropriate.

O Uso Não Racional De Anti-Histamínicos H1 E Efeitos Toxicológicos Em Crianças: Revisão Sistemática

“…Após a análise dos dados, observou-se que no grupo dos anti-histamínicos sedativos (AHS) uma proporção maior de pacientes com crises convulsivas superiores a 5 minutos foi predominante, contudo, não houve diferença significativa entre os grupos, ou seja, de acordo com (Daida et al; e de 13 a 18 anos (14,7%), intubação em crianças maiores de 12 anos (7,78%) e adultos (9,71%) e disritmia ventricular, que acometeu 3 crianças menores de 18 anos.…”

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

“…While the new-generation H 1 A has fewer side effects due to not passing the blood-brain barrier, it should be used with caution in younger children since this agent may disrupt the central anticonvulsant histaminergic system (21). Some studies have supported the use of optimal doses of H 1 antagonists in feverish children with allergic symptoms (13,18,24). Nevertheless, Daida et al (13) reported no significant association between antihistamine use and seizure duration, recommending the use of antihistamines for patients with a history of FS.…”

“…Some studies have supported the use of optimal doses of H 1 antagonists in feverish children with allergic symptoms (13,18,24). Nevertheless, Daida et al (13) reported no significant association between antihistamine use and seizure duration, recommending the use of antihistamines for patients with a history of FS.…”

“…Since sedative antihistamines prolong FS duration, the Japanese Society of Child Neurology released a set of guidelines in 2015, which contraindicated the use of sedative antihistamines in patients with FS. However, Daida et al (13) observed no significant between the antihistamine and non-user groups in terms of the mean duration of FS. Therefore, their findings could not support the correlation between sedative antihistamine use and the prolonged duration of FS (14,15).…”