The effects of Ang-1, IL-8 and TGF-β1 on the pathogenesis of COPD

Abstract

Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease‑altering therapies currently exist. Airway remodeling is one of the most important mechanisms in the pathogenesis of COPD and is triggered by chronic inflammation mediated by angiopoietin-1 (Ang-1), interleukin-8 (IL-8) and transforming growth factor-β1 (TGF-β1). The aim of this study was to investigate the effects of Ang-1, IL-8 and TGF-β1 on the pathogenesis of COPD. Forty-two COPD patients and 10 healthy adults (group A) were included in this study. We divided the 42 patients into 4 groups (groups B-E) according to the severity of the disease. We investigated the levels of Ang-1, IL-8 and TGF-β1 and the levels of pulmonary function (PF) in the stable and acute phases of COPD by enzyme-linked immunosorbent assay. We found statistically significant differences in the expression levels of Ang-1, IL-8 and TGF-β1 between the stable and acute phases in groups B-E. We found statistically significant differences in the expression levels of Ang-1 among all groups in the stable phase. In addition, there were statistically significant differences in the expression levels of TGF-β1 among all groups. There were statistically significant differences in the expression levels of IL-8 between group A and the other groups in the stable phase. Furthermore, in groups C-E we found higher correlations between Ang-1 and the forced expiratory volume in one second of forced vital capacity (FVC) [FEV1(%)] and FEV1/FVC(%) than between TGF-β1 and FEV1(%) and FEV1/FVC(%). We conclude that the blood vessel factor is more closely related to the pathogenesis of COPD.

Effects of Two Chinese Herbal Formulae for the Treatment of Moderate to Severe Stable Chronic Obstructive Pulmonary Disease: A Multicenter, Double-Blind, Randomized Controlled Trial

“…Interestingly, TGF-β1 could delay the development of COPD, and help repair damage to the lungs of individuals who are at risk of developing COPD, preserving the decline of FEV 1 [20], [21]. Recent researches provided the levels of TGF-β1 were different at four stages of COPD with highest in stage IV, and inversely correlated with FEV 1 (% predicted) and FVC (% predicted) [22], [23]. Our study showed a slight decline in both active treatment groups after 180 days.…”

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

“…This suggests that Ang-2 might be a useful biomarker for COPD exacerbations and might help clinicians identify patients at risk of worse outcomes at the start of an exacerbation. Supporting this finding, another group found that blood levels of Ang-1 are reduced during COPD exacerbations and increased when patients are clinically stable [119]. As Ang-2 acts as an Ang-1 antagonist perhaps increased Ang-2 levels in these patients resulted in a reduction of Ang-1.…”

The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells

“…The main role of IL-8 in inflammation is the recruitment and activation of neutrophils, which produce more ROS and contribute to local tissue destruction at sites of inflammation (Hammond et al, 1995;Casini et al, 1997). Thus, it involves the pathogenesis of lung diseases associated with inflammation such as asthma (Ordoñez et al, 2000), chronic obstructive pulmonary disease (Gao and Zhan, 2012), fibrosis (Radomska-Le sniewska et al, 2010), and bronchiolitis (Kim et al, 2005). In this study, the abundance of IL-8 expression was highest among all the cytokines that are regulated by PHMG-phosphate (Fig.…”