The effects of age on the response to caffeine

Swift, Cameron; Tiplady, B.

doi:10.1007/bf00735876

Cited by 112 publications

(97 citation statements)

References 12 publications

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“…The reported effect of caffeine on psychomotor function is somewhat conflicting (21,24,35), but, in this study, there was no indication that caffeine improved either reaction or movement times. The frequency of withdrawal symptoms (20,22,40) and side effects (21, 24) associated with caffeine, as well as the impaired postural stability (10,41), are in accordance with previous findings. Thus in one study by Franks et al (10), body sway was significantly increased in the young subjects 40 min after ingesting 4.3 mg/kg caffeine, and also elderly subjects in a study by Swift and Tiplady (41) showed an increased body sway on caffeine compared with placebo.…”

Section: Discussionsupporting

confidence: 91%

“…The frequency of withdrawal symptoms (20,22,40) and side effects (21, 24) associated with caffeine, as well as the impaired postural stability (10,41), are in accordance with previous findings. Thus in one study by Franks et al (10), body sway was significantly increased in the young subjects 40 min after ingesting 4.3 mg/kg caffeine, and also elderly subjects in a study by Swift and Tiplady (41) showed an increased body sway on caffeine compared with placebo. In this study, postural stability was impaired by 25 and 45% with eyes opened and closed, respectively.…”

Section: Discussionsupporting

confidence: 91%

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Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study

Nørager

Jensen

Madsen³

et al. 2005

Journal of Applied Physiology

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Norager, C. B., M. B. Jensen, M. R. Madsen, and S. Laurberg. Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study. J Appl Physiol 99: 2302-2306, 2005. First published August 4, 2005 doi:10.1152/japplphysiol.00309.2005.-This study investigated the effect of caffeine on physical performance in healthy citizens aged Ն70 yr. The randomized, double-blind, placebo-controlled, crossover study was conducted in 15 men and 15 women recruited by their general practitioner. Participants abstained from caffeine for 48 h and were randomized to receive one capsule of placebo and then caffeine (6 mg/kg) or caffeine and then placebo with 1 wk in between. One hour after intervention, we measured reaction and movement times, postural stability, walking speed, cycling at 65% of expected maximal heart rate, perceived effort during cycling, maximal isometric arm flexion strength, and endurance. Analysis was by intention to treat, and P Ͻ 0.05 was regarded as significant. Caffeine increased cycling endurance by 25% [95% confidence interval (CI): 13-38; P ϭ 0.0001] and isometric arm flexion endurance by 54% (95% CI: 29 -83; P ϭ 0.0001). Caffeine also reduced the rating of perceived exertion after 5 min of cycling by 11% (95% CI: 5-17; P ϭ 0.002) and postural stability with eyes open by 25% (95% CI: 2-53; P ϭ 0.03). Caffeine ingestion did not affect muscle strength, walking speed, reaction, and movement times. At the end of the study, 46% of participants correctly identified when they received caffeine and placebo. Caffeine increased exercise endurance in healthy citizens aged Ն70 yr, but the participants' reasons for stopping the test may have varied between subjects, as the cycling test was done at ϳ55% of maximal oxygen consumption. Further studies are required to investigate whether caffeine can be utilized to improve the physical performance of elderly citizens. fatigue; perceived exertion; postural stability; elderly CAFFEINE INGESTION INCREASES the endurance of young people exercising at 60 -85% of their maximal oxygen uptake (12,13,38). It also seems to improve endurance as measured by repeated submaximal isometric contraction (34) and decreases the rate of perceived exertion during exercise (6, 9, 37). Typically, doses of ϳ6 mg/kg caffeine (equivalent to 4 cups of coffee) were used in these studies.With a growing number of elderly with a physically active lifestyle and many elderly participating in rehabilitation programs, the endurance-enhancing effect of caffeine is of increasing interest in this age group. However, the enduranceenhancing effect of caffeine found in young subjects has not previously been examined in the elderly.The aim of this study was to investigate whether 6 mg/kg caffeine improves physical performance and reduces the perceived effort during work in healthy citizens aged Ն70 yr. The main hypothesis was that caffeine would improve cycling endurance at 65% of expected maximal heart rate, and the secondary hypothesis was that caffeine would improv...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study

Nørager

Jensen

Madsen³

et al. 2005

Journal of Applied Physiology

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“…Psychological and cognitive based studies have documented a range of improvements following ingestion of 250mg caffeine in older adults, including enhanced simple and choice reaction time performance in 50-65 year olds (11), enhanced reaction time performance in older adults (mean age = 57 years) 60 minutes following ingestion (12) and improved anticipatory timing (10). One suggestion for these results is that caffeine ingestion may reverse the effects of cognitive aging by making greater energy reserves available in older adults (13,14) with some evidence demonstrating that such effects of caffeine ingestion may be more marked in older adults compared to younger adults (11).…”

Section: Introductionmentioning

confidence: 99%

“…One suggestion for these results is that caffeine ingestion may reverse the effects of cognitive aging by making greater energy reserves available in older adults (13,14) with some evidence demonstrating that such effects of caffeine ingestion may be more marked in older adults compared to younger adults (11).…”

Section: Introductionmentioning

confidence: 99%

The effect of caffeine ingestion on functional performance in older adults

Duncan

Clarke

Tallis

et al. 2014

The Journal of nutrition, health and aging

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Caffeine is a widely used nutritional supplement which has been shown to enhance both physical and cognitive performance in younger adults.However, few studies have assessed the effect of caffeine ingestion on performance, particularly functional performance in older adults. The present study aims to assess the effect of acute caffeine ingestion on functional performance, manual dexterity and readiness to invest effort in older adults.Methods: 19 apparently healthy, volunteers (10 females and 9 males aged 61-79; 66±2 years) performed tests of functional fitness and manual dexterity post ingestion of caffeine (3mg*kg -1 ) or placebo in a randomised order. Pre and 60 minutes post ingestion, participants also completed measures of readiness to invest physical (RTIPE) and mental (RTIME) effort. Results: A series of repeated measures ANOVAS indicated enhanced performance in the following functional fitness tests; arm curls (P = .04), 8 foot up and go (P = .007), six minute walk (P = .016). Manual dexterity was also improved in the presence of caffeine (P = .001). RTIME increased (P = .015) pre to post ingestion in the caffeine condition but not in the placebo condition. There were no significant main effects or interactions for RTIPE or gender in any analysis (all P>.05). Conclusions: The results of this study suggest that acute caffeine ingestion positively enhances functional performance, manual dexterity and readiness to invest effort in apparently healthy older adults.

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“…3,4 Conversely, others have reported improvements in cognitive/attentional performance in older adults following caffeine ingestion. 5,6 These studies 5,6 have subsequently suggested that older adults are more susceptible to the performance-enhancing effects of caffeine than younger adults.…”

Section: Introductionmentioning

confidence: 99%

The effect of acute caffeine ingestion on coincidence anticipation timing in younger and older adults

Duncan

Tallis

Wright

et al. 2013

Nutritional Neuroscience

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Objectives: This study compared the effect of acute caffeine ingestion on coincidence timing accuracy in younger and older adults. Methods: Thirteen young (aged 18-25 years, age: 20 ± 2 years, 7 females, 5 males) and 13 older (aged 61-77 years, age: 68 ± 6 years, 9 females, 3 males) adults, all who were habitual moderate caffeine consumers undertook measures of coincident anticipation timing performance pre-and post-acute caffeine (3 mg/kg) or placebo ingestion administered in a double blind, randomized fashion. Results: Results indicated significant pre-to-post X substance (caffeine vs. placebo) interactions for absolute (P = 0.02, Pη 2 = 0.204) and variable error (P = 0.015, Pη 2 = 0.221). In both cases, error (absolute or variable) improved pre-to-post ingestion in the caffeine condition but not in the placebo condition. There were no significant differences due to age (younger vs. older adults, P > 0.05) in any of the analyses. Discussion: The results of this study suggest that acute caffeine ingestion positively influence coincidence anticipation timing performance in both younger and older adults, who are moderate habitual caffeine consumers. Such effects might therefore be useful for older adults in enhancing ability to undertake cognitive-perceptual tasks which involve interceptive actions.

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The effects of age on the response to caffeine

Cited by 112 publications

References 12 publications

Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study

Caffeine improves endurance in 75-yr-old citizens: a randomized, double-blind, placebo-controlled, crossover study

The effect of caffeine ingestion on functional performance in older adults

The effect of acute caffeine ingestion on coincidence anticipation timing in younger and older adults

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