The Effects of Acute Infection on Hematological Parameters

Sipahi, Tansu; Köksal, Tülin; Tavil, Betül; Akar, Nejat

doi:10.1080/08880010490477301

Cited by 22 publications

(22 citation statements)

References 14 publications

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“…Red cell distribution width is known to increase in ineffective red cell production and increased red cell destruction. These conditions are the common features of various infectious and inflammatory events . Studies in adults noted associations between increased RDW and high levels of acute phase reactants including erythrocyte sedimentation rate, CRP, and IL‐6 .…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width as a useful marker for severity in pediatric acute gastroenteritis

Korkmaz

Tutanç

Bostancı

et al. 2019

Pediatrics International

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Background Acute gastroenteritis (AGE) in children is still one of the most important causes of mortality and morbidity in developing countries. Therefore, it is very important for clinicians to detect the presence and severity of acute gastroenteritis. Red cell distribution width (RDW) is thought to have the potential for AGE evaluation in children. We sought to investigate the value of RDW for severity assessment in children with AGE. Methods A total of 97 AGE patients were included in a prospective observational study. Complete blood count, serum C‐reactive protein, and stool examinations were carried out. Modified Vesikari score (MVS) was evaluated to determine severity. Results Median age was 19 months (min–max, 1–198 months). The male/female ratio was 1.55 (59/38). Rotavirus was detected in 31 of 97 children (32%). median MVS was 9 points (min–max, 5–24 points). A total of 32 (33%), 43 (44%) and 22 patients (23%) were classified in the mild‐, moderate‐, and high‐severity groups, respectively. There were no significant differences between rotavirus‐positive and rotavirus‐negative children. Hemoglobin, mean corpuscular volume, and RDW differed significantly according to severity. RDW had the highest area under the curve when the high‐severity group was compared with the combination of low‐ and moderate‐severity groups on receiver operating characteristic analysis. Conclusions Red cell distribution width increased with the increase in severity of AGE. RDW may offer additional severity stratification in children with AGE.

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Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width as a useful marker for severity in pediatric acute gastroenteritis

Korkmaz

Tutanç

Bostancı

et al. 2019

Pediatrics International

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“…The effects of infection on serum ferritin levels may last for Ͼ15 days after exposure. 22,23 Serum soluble transferrin receptor (TfR) measurements have been shown to be a good indication of iron deficiency-induced erythropoiesis. 24 In addition, the ratio of ferritin to TfR has been suggested as a useful measure of body iron stores.…”

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confidence: 99%

Comparative Effectiveness of Zinc Protoporphyrin and Hemoglobin Concentrations in Identifying Iron Deficiency in a Group of Low-Income, Preschool-Aged Children: Practical Implications of Recent Illness

Crowell¹,

Ferris

Wood

et al. 2006

Pediatrics

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Compared with anemia, elevated zinc protoporphyrin levels identified significantly more iron-deficient children. Recently ill children were one half as likely to have low serum ferritin levels, compared with children without recent illness. The negative effect of recent illness on the positive predictive value of zinc protoporphyrin when ferritin is used to determine iron status has many practical implications.

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“…3 The resulting acute rise in RDW may therefore reflect the degree of the underlying inflammatory state and provide useful prognostic information about intensity of resource utilization and risk of mortality. [4][5][6][7] Some recent studies have found associations of an increased RDW with mortality, irrespective of mean cellular volume (MCV) and hemoglobin levels. Associations were reported for patients with heart failure, acute myocardial infarction, community-acquired pneumonia, pulmonary hypertension and in the general population.…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width as a prognostic marker in mechanically ventilated children admitted in pediatric critical care unit of tertiary care centre, India

Gadappa

Behera

2018

Int J Contemp Pediatr

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Background: Paediatric population is a vulnerable group necessitating standard care for medically and surgically ill children. Red cell distribution width (RDW) is a simple and low-cost measure that denotes the variability in red blood cell size. Any process that releases reticulocytes in the circulation will result in an increase in RDW. RDW may also be useful as a biomarker of disease severity and clinical outcomes in critically ill patients. Methods: Retrospective cohort study of all patients between 1month-12yrs of age, mechanically ventilated in Paediatric intensive care unit. Those patients with RDW on admission and complete data for PIM3 (Paediatric Index of Mortality 3) were included. Analyses included correlation, logistic regression analysis, and receiver operating characteristic (ROC) curves. Results: Retrospective analysis of data on 93 consecutive critically ill children admitted in PICU was done between Jan 2015-June 2016. We noted statistically significant correlation between mortality and anemia (10.24 g/dL, SD 2.26; 8.78 g/dL, SD 2.60.p = 0.009), LOS on MV (p = 0.008), RDW (p = 0.002), shock (p = 0.004) and ventilator associated Pneumonia (p = 0.024). Mortality increased as length of stay on mechanical ventilation increased (4.13 days, SD 2.125 versus 6.94 days, SD 7.603 p = 0.008). The cut-off of 18.10 was chosen as Mean RDW. Based on AUROC, RDW is independently associated with high risk of mortality. Conclusions: RDW measured within 24 hours of PICU admission was independently associated with length of stay on mechanical ventilation and mortality in a general PICU population. We recommend the need for multicentric, prospective longitudinal studies to determine the optimum utility of RDW to enhance decision making in PICU.

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The Effects of Acute Infection on Hematological Parameters

Cited by 22 publications

References 14 publications

Red blood cell distribution width as a useful marker for severity in pediatric acute gastroenteritis

Red blood cell distribution width as a useful marker for severity in pediatric acute gastroenteritis

Comparative Effectiveness of Zinc Protoporphyrin and Hemoglobin Concentrations in Identifying Iron Deficiency in a Group of Low-Income, Preschool-Aged Children: Practical Implications of Recent Illness

Red cell distribution width as a prognostic marker in mechanically ventilated children admitted in pediatric critical care unit of tertiary care centre, India

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