Red blood cell distribution width as a useful marker for severity in pediatric acute gastroenteritis

Abstract

Background Acute gastroenteritis (AGE) in children is still one of the most important causes of mortality and morbidity in developing countries. Therefore, it is very important for clinicians to detect the presence and severity of acute gastroenteritis. Red cell distribution width (RDW) is thought to have the potential for AGE evaluation in children. We sought to investigate the value of RDW for severity assessment in children with AGE. Methods A total of 97 AGE patients were included in a prospective observational study. Complete blood count, serum C‐reactive protein, and stool examinations were carried out. Modified Vesikari score (MVS) was evaluated to determine severity. Results Median age was 19 months (min–max, 1–198 months). The male/female ratio was 1.55 (59/38). Rotavirus was detected in 31 of 97 children (32%). median MVS was 9 points (min–max, 5–24 points). A total of 32 (33%), 43 (44%) and 22 patients (23%) were classified in the mild‐, moderate‐, and high‐severity groups, respectively. There were no significant differences between rotavirus‐positive and rotavirus‐negative children. Hemoglobin, mean corpuscular volume, and RDW differed significantly according to severity. RDW had the highest area under the curve when the high‐severity group was compared with the combination of low‐ and moderate‐severity groups on receiver operating characteristic analysis. Conclusions Red cell distribution width increased with the increase in severity of AGE. RDW may offer additional severity stratification in children with AGE.

Role of neutrophil-to-lymphocyte, mean platelet volume-to-platelet and platelet-to-lymphocyte ratios as predictors of disease severity in Rotavirus gastroenteritis

“…Furthermore, numerous studies indicate that RDW can be used as diagnostic markers for disease severity (27,28). RDW and RG have only been studied once, and higher RDW levels were linked to severe rotavirus gastroenteritis (17). Severe and non-severe groups had significantly higher RDW levels than controls in our study however the increase in RDW was not associated with disease severity.…”

“…BUN, creatinine, and blood gases (pH, serum bicarbonate) were discovered to be useful clinical markers to determine dehydration and severity in children with acute gastroenteritis (17)(18)(19). Higher levels of creatinine, BUN, potassium, and lower glucose, pH, bicarbonate, albumin levels in severe group were related to the serious dehydration and acidosis.…”