The effects of a topically‐active non‐steroidal anti‐inflammatory drug on ligature‐induced periodontal disease in the squirrel monkey*

Vogel, Richard I.; Schneider, Lawrence C.; Goteiner, David

doi:10.1111/j.1600-051x.1986.tb01447.x

Cited by 35 publications

(16 citation statements)

References 12 publications

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“…Topical applications may provide a viable and more practical alternative to systemic therapy. Vogel et al (1986) have demonstrated both clinically and histologically. that a subsituted oxazolo pyridine derivative PG synthetase inhibitor signiflcantly reduces gingival inflammation and loss of attachment in the squirrel monkey.…”

Section: Nsaios and Periodontai Dls«as«mentioning

confidence: 99%

Drugs and the periodontium

Seymour

Heasman

1988

J Clinic Periodontology

128

113

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The periodontium and periodontal disease activity can be affected by systemic drug therapy. Many drugs can have an adverse effect on the periodontium, i.e., gingival hyperplasia. Alternatively, some drugs can modify the inflammatory and immunological responses of the periodontal tissues to bacterial plaque. The aim of this review is to evaluate the effects of drug therapy on the periodontium and periodontal disease activity, and where possible, to relate such changes to the pharmacodynamics of the drugs considered. Drugs which have been reported to affect the periodontium can be categorised as follows: anti-epileptics, immunosuppressants, corticosteroids, non-steroidal anti-inflammatory drugs and hormones. Those drugs whose pharmacodynamics are clearly established and which affect the rate of periodontal disease activity, may provide information on the mechanisms of periodontal destruction. Finally, the mechanisms of drug-induced gingival hyperplasia (overgrowth) are discussed in relationship to the drugs' pharmacodynamics and pharmacokinetics.

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Section: Nsaios and Periodontai Dls«as«mentioning

confidence: 99%

Drugs and the periodontium

Seymour

Heasman

1988

J Clinic Periodontology

128

113

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“…Topical application of fiurbiprofen or a substituted oxazolopyridine derivative in animals has been shown to reduce gingival inflammation (Williams et al 1988), attachment loss as well as periodontal bone loss (Vbgel et al 1986). Topical application of fiurbiprofen or a substituted oxazolopyridine derivative in animals has been shown to reduce gingival inflammation (Williams et al 1988), attachment loss as well as periodontal bone loss (Vbgel et al 1986).…”

mentioning

confidence: 99%

Adjunctive supragingival irrigation with acetylsalicyclic acid in periodontal supportive therapy

Flemmig

Epp

Funkenhauser

et al. 1995

J Clinic Periodontology

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To assess the clinical efficacy of adjunctive supragingival irrigation with buffered 0.3% acetylsalicylic acid (ASA), 60 patients with periodontitis receiving supportive periodontal therapy were randomly assigned to 1 of 3 home regimens: (1) 1x daily adjunctive supragingival irrigation with 300 ml water immediately followed by 200 ml of buffered 0.3% ASA; (2) 1x daily adjunctive supragingival irrigation with 500 ml water; or (3) normal oral hygiene alone. Clinical parameters were assessed at baseline and 6 months. Irrigator use was measured by timers built into the irrigator units. Results at 6 months showed that both supragingival irrigation with buffered 0.3% ASA and supragingival irrigation with water significantly reduced gingival index scores (median 0.1 and 0.35, respectively) and pocket probing depths (both median 0.26 mm) compared to the control group. In addition, irrigation with water resulted in a significant reduction in bleeding on probing (median 0.13), whereas irrigation with buffered 0.3% ASA had no significant effect on bleeding on probing compared to the control group. The clinical efficacy of irrigation with either ASA or water was found to be positively correlated to initial disease severity and irrigator use. Thus, frequent supragingival irrigation with either 0.3% ASA or water in addition to regular oral hygiene appears to be a beneficial adjunct to periodontal supportive therapy in patients with moderate to severe signs of periodontitis. However, the use of buffered 0.3% ASA as an irrigant does not seem to enhance the clinical efficacy of supragingival irrigation on periodontal health.

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“…Clearly, then, inhibitors of cyclooxygenase such as aspirin-like drugs should have an effect on the course of periodontal disease progression. The data from animal experiments and human observation would support this concept, and indicate that aspirin-like drugs diminish gingival inflatnmation and reduce alveolar bone resorption (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 91%

Topical flurbiprofen treatment of periodontitis in beagles

Williams

Jeffcoat

Howell

et al. 1988

J of Periodontal Research

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The effect of the non‐steroidal anti‐inflammatory drug flurbiprofen, topically applied, on the progression of periodontal disease was studied in 12 beagle dogs over a 13‐month period. Standardized radiographs were used to measure the rate of bone loss. Following a 6‐month pretreatment baseline period, 6 dogs were treated daily with 0.3 mg flurbiprofen gently applied to the gingival margin in 1 ml of gel vehicle. Six untreated dogs served as controls. In the untreated control dogs the rate of bone loss in the treatment period did not change significantly from baseline, although the rate was elevated by 38%. In contrast, the rate of bone loss significantly decreased by 71% from baseline in the flurbiprofen‐treated dogs. The untreated control dogs lost 10 teeth during the treatment period whereas the topical flurbiprofen‐treated dogs lost only 1 tooth. The data indicate that topical application of flurbiprofen in a gel vehicle significantly inhibits alveolar bone loss in beagles over a 7‐month treatment period. The data also indicate that topical flurbiprofen is associated with the loss of considerably less teeth than in untreated control dogs over the 7‐month treatment period.

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The effects of a topically‐active non‐steroidal anti‐inflammatory drug on ligature‐induced periodontal disease in the squirrel monkey*

Cited by 35 publications

References 12 publications

Drugs and the periodontium

Drugs and the periodontium

Adjunctive supragingival irrigation with acetylsalicyclic acid in periodontal supportive therapy

Topical flurbiprofen treatment of periodontitis in beagles

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