Adjunctive supragingival irrigation with acetylsalicyclic acid in periodontal supportive therapy

Flemmig, Thomas Frank; Epp, Birgitta; Funkenhauser, Zita; Newman, Michael G.; Kornman, Kenneth S.; Haubitz, Imme; Klaiber, B

doi:10.1111/j.1600-051x.1995.tb00173.x

Cited by 39 publications

(49 citation statements)

References 18 publications

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“…The effects of irrigation with different medicaments and with water on gingival and periodontal health have been assessed in many studies, and results found showed consistent benefits in healthy subjects (Cobb et al 1988, Flemmig et al 1995, Cutler et al 2000). Electron microscopic studies have shown evidence of bacterial cell disruption following water irrigation (Brady et al 1973).…”

mentioning

confidence: 99%

“…Clinical efficacy of irrigation with water alone was compared to the irrigation with water and buffered 0.3% acetylsalicylic acid, and normal oral hygiene alone (control group). Result showed that supragingival irrigation with water alone or in combination with buffered 0.3% acetylsalicylic acid significantly improved GI and PPD scores when compared to regular oral hygiene alone (Flemmig et al 1995). It was also noted in the same study that supragingival irrigation with water alone resulted in a significant reduction in BOP when compared to both irrigation with buffered 0.3% acetylsalicylic acid and with control groups.…”

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confidence: 99%

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Comparative evaluation of adjunctive oral irrigation in diabetics

Al-Mubarak

Ciancio

Aljada

et al. 2002

J Clinic Periodontology

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mentioning

confidence: 99%

mentioning

confidence: 99%

Comparative evaluation of adjunctive oral irrigation in diabetics

Al-Mubarak

Ciancio

Aljada

et al. 2002

J Clinic Periodontology

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“…Thus, regular supragingival irrigation with either 0.3% ASA or water besides usual oral hygiene seems to be a valuable extra periodontal supportive remedy in patients showing the signs of moderate to severe periodontitis. [20] Antiseptic irrigations have been employed for managing plaque buildup. [21] Peridex, Perioguard and Listrine are the antiseptic irrigations clinically approved by American Dental Association.…”

Section: Strategies For Maintenance Of Good Oral Hygienementioning

confidence: 99%

Treatment modalities and evaluation models for periodontitis

Tariq¹,

Iqbal²,

Ali³

et al. 2012

Int J Pharma Investig

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Periodontitis is the most common localized dental inflammatory disease related with several pathological conditions like inflammation of gums (gingivitis), degeneration of periodontal ligament, dental cementum and alveolar bone loss. In this perspective, the various preventive and treatment modalities, including oral hygiene, gingival irrigations, mechanical instrumentation, full mouth disinfection, host modulation and antimicrobial therapy, which are used either as adjunctive treatments or as stand-alone therapies in the non-surgical management of periodontal infections, have been discussed. Intra-pocket, sustained release systems have emerged as a novel paradigm for the future research. In this article, special consideration is given to different locally delivered anti-microbial and anti inflammatory medications which are either commercially available or are currently under consideration for Food and Drug Administration (FDA) approval. The various in vitro dissolution models and microbiological strain investigated to impersonate the infected and inflamed periodontal cavity and to predict the in vivo performance of treatment modalities have also been thrashed out. Animal models that have been employed to explore the pathology at the different stages of periodontitis and to evaluate its treatment modalities are enlightened in this proposed review.

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“…The clinical efficacy of adjunctive supragingival irrigation with 0.3% buffered acetylsalicylic acid (ASA) was assessed in patients with periodontitis receiving supportive periodontal therapy and compared to water irrigation alone [57]. Clinical parameters were assessed at baseline and at 6 months.…”

Section: Effects Of Adjunctive Nsaids Administration On Supportive Pementioning

confidence: 99%

“…These observations suggest that much of the clinically visible gingival inflammation is associated with neutrophil LTB 4 synthesis that would not be inhibited by most NSAIDs. This may explain the weak efficacy of NSAIDs in blocking clinical signs of gingival inflammation [57,58]. The NSAID ketoprofen, which is an inhibitor of both the cyclooxygenase and lipoxygenase pathways, may be a notable exception [59].…”

Section: B Arachidonic Acid Metabolite Levels In Periodontal Tissuesmentioning

confidence: 99%

The Effects of Non-Steroidal Anti-Inflammatory Drugs (Selective and Non-Selective) on the Treatment of Periodontal Diseases

Salvi

Lang

2005

CPD

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The objective was to review the literature on the effects of selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) on the treatment of periodontal diseases. A search of MEDLINE was conducted and articles published in English until December 2003 were included. The results from in vitro and animal experiments as well as from human clinical trials are presented. Non-selective cyclooxygenase-1 (COX-1) inhibitors used in periodontal research include compounds such as aspirin, flurbiprofen, ibuprofen, naproxen and piroxicam. Selective cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical products termed "coxibs" that include meloxicam, nimesulide, etodolac and celecoxib. Evidence from animal experiments and clinical trials documents that selective and non-selective NSAIDs are mainly responsible for the stabilization of periodontal conditions by reducing the rate of alveolar bone resorption. This is achieved through local inhibition of both enzymes (e.g. COX-1 and COX-2) responsible for the synthesis of arachidonic acid metabolites. Evidence shows that the effects of NSAIDs drop off rapidly after drug withdrawal. One of the major advantages of selective COX-2 inhibition is the reduction of adverse systemic effects. Although some studies present promising results, no data from long-term, multicenter prospective clinical trials are yet available for determining whether these therapeutic effects can be retained on a long-term basis. Many of these compounds, such as flurbiprofen, are readily absorbed through the gingival tissues. Therefore, the development of topical NSAIDs formulations (e.g. gels, toothpastes, rinses) with a daily application seems to be of particular interest. This may help to further reduce adverse systemic effects of non-selective NSAIDs in the long-term host modulation of periodontitis-susceptible patients.

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Adjunctive supragingival irrigation with acetylsalicyclic acid in periodontal supportive therapy

Cited by 39 publications

References 18 publications

Comparative evaluation of adjunctive oral irrigation in diabetics

Comparative evaluation of adjunctive oral irrigation in diabetics

Treatment modalities and evaluation models for periodontitis

The Effects of Non-Steroidal Anti-Inflammatory Drugs (Selective and Non-Selective) on the Treatment of Periodontal Diseases

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