The Effects of a Standardized Extract of <i>Centella asiatica</i> on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial

Damkerngsuntorn, Wilawan; Rerknimitr, Pawinee; Panchaprateep, Ratchathorn; Tangkijngamvong, Natsinee; Kumtornrut, Chanat; Kerr, Stephen J.; Asawanonda, Pravit; Tantisira, Mayuree H.; Khemawoot, Phisit

doi:10.1089/acm.2019.0325

Cited by 23 publications

(18 citation statements)

References 23 publications

(26 reference statements)

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“…All experimental animals showed good tolerability to the test substances after oral and intravenous administration. The results implied that the test substances, especially Centell-S, are safe in animals, a finding that is in line with our previous reports in standardised extract of C. asiatica 14 , 15 , 19 , 23 . After intravenous administration of Centell-S, the plasma concentrations of madecassoside and asiaticoside were slightly lower than after pure compound administration.…”

Section: Discussionsupporting

confidence: 91%

Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs

Boonyarattanasoonthorn

Kijtawornrat

Songvut

et al. 2022

Sci Rep

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A newly standardised extract of Centellaasiatica (Centell-S) with better water solubility than the previous standardised extract of C.asiatica (ECa 233) was developed, and pharmacokinetic profiles of bioactive triterpenoids were investigated in beagle dogs. The test substances were administered via intravenous or oral administration with single and multiple doses for 7 days. The concentrations of major bioactive triterpenoids, including madecassoside, asiaticoside, madecassic acid, and asiatic acid, in biological samples were measured by liquid chromatography–tandem mass spectrometry. The dogs in this study showed good tolerability to all test substances, based on the physical appearance and blood chemistry 24 h after dosing. The major bioactive triterpenoids found in systemic blood circulation were madecassoside, asiaticoside, and asiatic acid; the concentration of these components ranged from 1 to 10,000 µg/L after intravenous administration of 1.0 mg/kg Centell-S. Oral administration of 10 and 20 mg/kg Centell-S generated approximately twofold higher plasma levels of both madecassoside and asiaticoside compared with equivalent doses of ECa 233. In addition, there was an accumulation of triterpenoid glycosides after multiple oral administrations of Centell-S for 7 days, while triterpenic acids showed little tendency for accumulation. Beagles had good tolerability to both standardised extracts of C.asiatica, and showed a similar pattern of bioactive triterpenoids to humans. Centell-S increased oral bioavailability of major triterpenoid glycosides and can be further developed into a phytopharmaceutical product.

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Section: Discussionsupporting

confidence: 91%

Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs

Boonyarattanasoonthorn

Kijtawornrat

Songvut

et al. 2022

Sci Rep

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“…In contrast to the abundant in vivo evidence of the wound-healing effect of C. asiatica , clinical studies are sparse. Yet, one clinical trial showed a significant improvement in post-laser-resurfacing wound healing in patients with bilateral atrophic facial acne scars treated with ECa 233 gel for three months compared to the patients in the control group [ 50 ].…”

Section: Pharmacological Effects Of Centella Asiatica On Skin Diseasesmentioning

confidence: 99%

Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms

Park

2021

Evidence-Based Complementary and Alternative Medicine

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The medicinal herb Centella asiatica (L.) Urban known as gotu kola has been reported to exhibit a wide range of pharmacological activities. In particular, a significant body of scientific research exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment of skin diseases. The present study is aimed to provide a comprehensive overview of the beneficial effects of C. asiatica on skin diseases. Peer-reviewed articles on the potent dermatological effects of C. asiatica were acquired from PubMed, Web of Science, Scopus, ScienceDirect, and SciFinder. This review provides an understanding of pharmacological studies which confirm the potent dermatological effects and underlying molecular mechanisms of C. asiatica. This medicinal plant and its triterpenes include asiaticoside, madecassoside, and their aglycones, asiatic acid and madecassic acid. These compounds exert therapeutic effects on dermatological diseases such as acne, burns, atopic dermatitis, and wounds via NF-κB, TGF-β/Smad, MAPK, Wnt/β-catenin, and STAT signaling in in vitro and in vivo studies. However, additional rigorously controlled long-term clinical trials will be necessary to confirm the full potential of C. asiatica as a therapeutic agent.

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“…Four studies [ 59 , 60 , 61 , 62 ] on C. asiatica were included in the systematic review ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Effect of Centella asiatica on Wound Healing

Arribas-López

Занд

Ojo

et al. 2022

IJERPH

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Background: Under metabolic stress conditions, there is a higher demand for nutrients which needs to be met. This is to reduce the risk of delay in wound healing which could lead to chronic wound. Aim: This is a systematic review of the effect of Centella asiatica on wound healing. C. asiatica is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, neuroprotective, and wound healing properties. Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for the systematic review and four electronic databases were used. Results: Four clinical trials met the inclusion criteria. The following distinct areas were identified under C. asiatica: wound contraction and granulation; healing/bleeding time and re-epithelialization; VAS (visual analogue scale) scores; skin erythema and wound appearance. Conclusions: C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production. Besides, C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity. Delivery systems such as nanoencapsulation could be used to increase C. asiatica bioavailability. Nevertheless, more studies are needed in order to perform a meta-analysis and ascertain the effects of C. asiatica on wound healing and its different parameters.

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The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial

Cited by 23 publications

References 23 publications

Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs

Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs

Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms

A Systematic Review of the Effect of Centella asiatica on Wound Healing

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