The effects of a new antidiabetic glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in high-fat diet of streptozotocin-induced diabetic rats

Komeili, Gholamreza; Ghasemi, Fatemeh; Rezvani, Ali Reza; Ghasemi, Khaled; Sameni, Farzaneh Khadem; Hashemi, Mohammad

doi:10.1080/13813455.2019.1663218

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Yellow solid from glacial acetic acid, yield ( 1.35 g, 71%), mp: 232-234 0 C; IR (KBr, cm −1 ): 3037 (=C-H), 2216 (-CN); 1 H-NMR: δ 3.03 (s, 6H, (CH3)2-N-), 6.88 (d, J = 0.6 Hz, 1H, -C6H3-H), 6.91 (d, J = 0.5 Hz, 1H, -C6H3-H), 7.25 (dd, J = 3.9 and 0.9 Hz, 1H, thienyl-H), 7.58-7.93 (m, 9H, Ar-H + thienyl-H), 8.07 (s, 1H, Pyridine-H); MS (m/z, %): 383 (M+2, 8), 382 (M+1, 28), 381 (M+, 100), 271 (17), 189 (8), 77 (17), 57 (7)…”

Section: -(4-(dimethylamino)phenyl)-3-phenyl-6-(thiophen-2-yl)picolinonitrile (8b)mentioning

confidence: 99%

“…Yellow solid from glacial acetic acid, yield ( 1.19 g, 65%), mp: 272-274 0 C; IR (KBr, cm −1 ): 3055 (=C-H), 2897 (-C-H), 2214 (-CN); 1 H-NMR: δ 3.02 (s, 6H, (CH3)2-N-), 6.75 (q, J = 1. 7…”

Section: -(4-(dimethylamino)phenyl)-6-(furan-2-yl)-3phenylpicolinonitrile (8c)mentioning

confidence: 99%

“…Pyridines are class of organic heterocyclic compounds consisting of six-member ring of five carbons and one nitrogen atom. Pyridines and their derivatives exhibit various pharmacological properties such as antimicrobial [1-3], antiviral [4,5], antioxidant [2,6], antidiabetic [7,8], anticancer [9][10][11], antimalarial [12], anti-inflammatory [13,14], analgesic [13,15], anti-convulsant [13,15], and antiparkansonian agents [13,15].…”

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Novel Pyrazoles, Pyrazolines, and Pyridines From Chalcone Derivatives With the Assessment of Their in Vitro Anticancer Activity Against T-47d and Uacc-257 Cell Lines

2020

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Novel series of pyrazoline carbothioamides, acetyl pyrazoles, pyridine-3-carbonitrile, pyridine-2-carbonitriles, and nicotinonitriles were synthesized. The structures of the newly synthesized compounds were established based on their spectral data, elemental analyses and alternative synthetic routes whenever possible. Also, the newly synthesized compounds were screened for their in vitro anticancer activity against T-47D (breast cancer human cell line) and UACC-257 (melanoma human cell line) by MTT assay (a colorimetric assay for assessing cell metabolic activity). Experimental results demonstrated that compounds 3a, 4a, and 8c showed excellent in vitro activity against against T-47D cell line, while compounds 3d, 6d, and 5b exhibited excellent activity against UACC-257 cell line. Molecular docking studies were performed on compound 4a, as it showed the most promising activity against T-47D cell line, using Molecular Operation Environment (MOE 2008.10) software. Also, drug-likeness, pharmacokinetics, and toxicity assessment studies were carried out.

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Section: -(4-(dimethylamino)phenyl)-3-phenyl-6-(thiophen-2-yl)picolinonitrile (8b)mentioning

confidence: 99%

Section: -(4-(dimethylamino)phenyl)-6-(furan-2-yl)-3phenylpicolinonitrile (8c)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Novel Pyrazoles, Pyrazolines, and Pyridines From Chalcone Derivatives With the Assessment of Their in Vitro Anticancer Activity Against T-47d and Uacc-257 Cell Lines

2020

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“…Nowadays, one of the most important causes of morbidity and mortality is type 2 diabetes mellitus (T2DM) that influences a large number of people worldwide (Komeili et al 2019). Its prevalence in 2040 might reach around 642 million people (Bellou et al 2018).…”

mentioning

confidence: 99%

Oxidative stress in liver of streptozotocin-induced diabetic mice fed a high-fat diet: A treatment role of Artemisia annua L.

Ghanbari,

Shokrzadeh Lamuki,

Sadeghimahalli

et al. 2023

Endocrine Regulations

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Objective. The aim of this study was the investigation of a treatment role of Artemisia annua L. (AA) on liver dysfunction and oxidative stress in high-fat diet/streptozotocin-induced diabetic (HFD/STZ) mice. Methods. Sixty mice were divided into 12 groups including control, untreated diabetic, and treated diabetic ones with metformin (250 mg/kg), and doses of 100, 200, and 400 mg/kg of water (hot and cold) and alcoholic (methanol) extracts of AA. Type 2 diabetes mellitus (T2DM) was induced in mice by high-fat diet for 8 weeks and STZ injection in experimental animals. After treatment with doses of 100, 200 or 400 mg/kg of AA extracts in HFD/STZ diabetic mice for 4 weeks, oxidative stress markers such as malondialdehyde (MDA), glutathione (GSH), and free radicals (ROS) were determined in the liver tissue in all groups. Results. Diabetic mice treated with metformin and AA extracts showed a significant decrease in ROS and MDA concentrations and a notable increase in GSH level in the liver. Effectiveness of higher doses of AA extracts (200 and 400 mg/kg), especially in hot-water and alcoholic ones, were similar to and/or even more effective than metformin. Conclusion. Therapeutic effects of AA on liver dysfunction showed that antioxidant activity of hot-water and alcoholic AA extracts were similar or higher than of metformin.

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Investigating the biological activities and prebiotic potential of exopolysaccharides Produced by Lactobacillus delbrueckii and Lacticaseibacillus rhamnosus: Implications for gut microbiota modulation and rheological properties in fermented milk

Tarique,

Ali,

Kizhakkayil

et al. 2023

Food Hydrocolloids for Health

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The effects of a new antidiabetic glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in high-fat diet of streptozotocin-induced diabetic rats

Cited by 3 publications

References 33 publications

Design and Synthesis of Novel Pyrazoles, Pyrazolines, and Pyridines From Chalcone Derivatives With the Assessment of Their in Vitro Anticancer Activity Against T-47d and Uacc-257 Cell Lines

Design and Synthesis of Novel Pyrazoles, Pyrazolines, and Pyridines From Chalcone Derivatives With the Assessment of Their in Vitro Anticancer Activity Against T-47d and Uacc-257 Cell Lines

Oxidative stress in liver of streptozotocin-induced diabetic mice fed a high-fat diet: A treatment role of Artemisia annua L.

Investigating the biological activities and prebiotic potential of exopolysaccharides Produced by Lactobacillus delbrueckii and Lacticaseibacillus rhamnosus: Implications for gut microbiota modulation and rheological properties in fermented milk

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