The effects of a low dose of cabergoline on induction of estrus and pregnancy rates in anestrous bitches

Manipulation of the oestrous cycle of the bitch—what works… for now

“…The two oral formulations which have been used are cabergoline at the dose of 5 μg kg −1 day −1 and bromocriptine at an increasing dose (up to 0.1 mg kg −1 day −1 ) until the appearance of proestrous signs. A reduced dosage of cabergoline (0.6 μg kg −1 day −1 ) was shown to be effective as well (Ajitkumar, Praseeda, Rajankutty, & Alex, ; Cirit et al., ). The duration of treatment varies from 8 to 40 days, and the efficacy of oestrous induction is highly associated with the stage of anestrus when the treatment is started (Van Haaften et al., ; Verstegen, Onclin, Silva, & Concannon, ).…”

“…As shown for the efficacy regarding oestrous induction, the pregnancy rate is influenced by the stage of anestrus, in which the treatment is performed with better results if treatment takes place in late anestrus. Pregnancy rates of 70% to 100% have been obtained after oestrous induction using dopamine agonists (Ajitkumar et al., ; Cirit et al., ; Gobello, Castex, & Corrada, ; Günay, Günay, & Soylu, ; Shimatsu, ; Verstegen et al., ; Zöldág, Fekete, Csáky, & Bersényi, ). In a recent study, the administration of oestradiol benzoate (unauthorized in many countries due to severe side effects), 1 week before the start of cabergoline treatment, led to significant reduction of the time span until the onset of proestrus and showed a synchronizing effect.…”

“…The longer the interval from the previous oestrus is, the better are the results. Therefore, the prefect candidate should be in progressed to late anestrus (vaginal cytology of anestrus and progesterone levels less than 1 ng/ml) was shown to be effective as well (Ajitkumar, Praseeda, Rajankutty, & Alex, 2010;Cirit et al, 2007). The duration of treatment varies from 8 to 40 days, and the efficacy of oestrous induction is highly associated with the stage of anestrus when the treatment is started (Van Haaften et al, 1989;Verstegen, Onclin, Silva, & Concannon, 1999).…”

Pharmacologic Advances in Canine and Feline Reproduction

“…Estrus induction in canine and feline patients has been accomplished with a variety of pharmaceutical agents. [1][2][3][4][5][6] Estrous induction is most successful in normal females; its efficacy in bitches and queens with reproductive disorders is unknown. Agents reported to be effective include synthetic estrogens (diethylstilbestrol [DES]), dopamine agonists (bromocriptine, cabergoline), GnRH agonists (lutrelin, buserelin, fertirelin, deslorelin, and leuprolide), exogenous gonadotro-pins (LH), follicle-stimulating hormone (FSH), human chorionic gonadotropin (HCG), pregnant mare serum gonadotropin (PMSG), and opiate antagonists (naloxone).…”

Induction of ovarian activity and ovulation in an induced ovulator, the maned wolf (Chrysocyon brachyurus), using GnRH agonist and recombinant LH

“…For example, hCG fails to support luteal function [13] and has no positive effects on ovulation rates in domestic dogs [14]. However, Write [15] reports that ovulation in domestic dogs is induced by hCG within 26 to 30 hours of administration.…”