Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt, Cindy; Santos, N.R.; Fontbonne, Alain

doi:10.1111/rda.13364

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…A synthetic analog of gonadotropinreleasing hormone (GnRH) -deslorelin, which is the active substance of the implant, provides a pulsating release of a hormone that has an effect similar to the action of natural GnRH (Kutzler, 2005;. Deslorelin is GnRH agonist that stimulates estrus in adult dogs (Maenhoudt et al, 2018).…”

Section: Fig 4 Non-nuclear Cells Dynamics During the Estrous Cycle In...mentioning

confidence: 99%

Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin)

Holumbiiovska

Stefanyk

Basarab

2021

Ukr. Jour. of Vet. and Agr. Sci.

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Diagnosis of the estrous cycle in female dogs is important in veterinary medicine. The estrous cycle is divided into the following stages: proestrus, estrus, diestrus, metestrus, and anestrus, which due to the action of hormones, replace one after another. This feature of the estrous cycle leads to some difficulties with reproduction. It is hard to obtain newborns because of prolonged anestrus. Vaginal cytology is a simple and available diagnostic method of the estrous cycle. It is based on the analysis of vaginal mucosa epithelial cells changes. This method is used to determine the time of mating and diagnose pathological conditions in the reproductive system of female dogs. There are various drugs in veterinary medicine for the correction of the estrous cycle in female dogs. We used implant Suprelorin® to estrus induction. There were described methods of estrus stimulation using a subcutaneous implant Suprelorin (4.7 mg, deslorelin) and changes in vaginal epithelial cells using the vaginal cytology method. The study was performed on twelve (n = 12) adult female dogs in the anestrus stage. Implants were injected subcutaneously in the groin area and removed at the beginning of the estrus.

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Section: Fig 4 Non-nuclear Cells Dynamics During the Estrous Cycle In...mentioning

confidence: 99%

Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin)

Holumbiiovska

Stefanyk

Basarab

2021

Ukr. Jour. of Vet. and Agr. Sci.

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“…Upon reviewing the existing literature and considering the preference expressed by the owner to keep the litter, the decision to remove the implant was predominantly influenced by the case report conducted by Goericke-Pesch et al, 7 which highlighted a lack of maternal behaviour and milk production after a pregnancy in a queen with a deslorelin implant. Contrary to the bitch, where the deslorelin implant has been used off-label to induce oestrus with a considerable (60%) level of fertility, 15 we still know little about this application in the queen. Considering this case and the current literature, it appears possible to not only induce fertile ovulation and heat in oestrus and post-oestrus queens, 3 but also to carry to term a normal pregnancy without side effects for the queen and the litter, thanks to removal of the implant during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Successful parturition and lactation after a deslorelin implant removal in a pregnant cat

Paganotto,

Truttmann,

Rosset

2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary The aim of this clinical case presentation was to describe the effect of a 4.7 mg deslorelin implant placement in a pregnant queen during the second half of gestation, and the consequences of its removal on the pregnancy and parturition. A 5-year-old female cat exhibiting nesting behaviour and weight gain 10 days after placement of a deslorelin implant was presented for examination. Gestation was confirmed on ultrasound, with two well-formed kittens of a gestational age of approximately 7 weeks. The deslorelin implant placed on the umbilicus was removed 1 week later. No change in the pregnancy was observed after removal of the implant. The fetuses showed no signs of distress on ultrasound and radiography examination 4 days after removal of the implant. One week after implant removal, the queen naturally delivered two healthy kittens. The queen showed maternal behaviour with normal milk production. Relevance and novel information In the light of the lack of literature on implant injection and removal in the pregnant queen, this case report showcases a successful birth of healthy kittens without any subsequent adverse effect on the queen. Further study is needed to assess the safety of implant removal during pregnancy and potential use as a means to induce fertile oestrus in the queen.

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“…There are indeed different pharmacological protocols to induce oestrus, such as dopamine agonists (anti‐prolactinergic drugs like cabergoline and bromocriptine) and GnRH agonists (such as deslorelin). However, induction of heat is not easy to obtain and the longer the interval from the previous oestrus is, the better the expected results of the induction are (Maenhoudt et al., 2018 ). However, a healthy and regular bitch will return to heat based on her normal cyclicity and there is no need for induction.…”

Section: Judgement 2: Healthmentioning

confidence: 99%

Scientific and technical assistance on welfare aspects related to housing and health of cats and dogs in commercial breeding establishments

Candiani,

Drewe,

Forkman

et al. 2023

EFS2

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This Scientific Report addresses a mandate from the European Commission according to Article 31 of Regulation (EC) No 178/2002 on the welfare of cats and dogs in commercial breeding establishments kept for sport, hunting and companion purposes. The aim was to scrutinise recent recommendations made by the EU Platform on Animal Welfare Voluntary Initiative on measures to assist the preparation of policy options for the legal framework of commercial breeding of cats and dogs. Specifically, the main question addressed was if there is scientific evidence to support the measures for protection of cats and dogs in commercial breeding related to housing, health considerations and painful procedures. Three judgements were carried out based on scientific literature reviews and, where possible a review of national regulations. The first judgement addressed housing and included: type of accommodation, outdoor access, exercise, social behaviour, housing temperature and light requirements. The second judgement addressed health and included: age at first and last breeding, and breeding frequency. Judgement 3 addressed painful procedures (mutilations or convenience surgeries) and included: ear cropping, tail docking and vocal cord resections in dogs and declawing in cats. For each of these judgements, considerations were provided indicating where scientific literature is available to support recommendations on providing or avoiding specific housing, health or painful surgical interventions. Areas where evidence is lacking are indicated.

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Manipulation of the oestrous cycle of the bitch—what works… for now

Cited by 10 publications

References 53 publications

Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin)

Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin)

Successful parturition and lactation after a deslorelin implant removal in a pregnant cat

Scientific and technical assistance on welfare aspects related to housing and health of cats and dogs in commercial breeding establishments

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