The Effects of a Long-Term Physical Activity Intervention on Serum Uric Acid in Older Adults at Risk for Physical Disability

Beavers, Kristen M.; Hsu, Fang Chi; Serra, Monica C.; Yank, Veronica; Pahor, Marco; Nicklas, Barbara J.

doi:10.1123/japa.2012-0018

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…However, smoking could also reduce endogenous production of UA (an antioxidant) via inducing oxidative stress. Similarly, the relationship between physical activity and UA status is complicated; moderate–vigorous physical activity results in a modest increase in systemic concentration of UA and light‐intensity physical activity may be associated with the lower UA concentrations in obese individuals . We did not observe a significant relationship between diet and future risk of hyperuricemia.…”

Section: Discussionmentioning

confidence: 53%

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

Meng

Huang

et al. 2016

Arthritis Care & Research

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Objective. Hyperuricemia has been shown to be associated with increased risks of gout and cardiovascular diseases. We prospectively investigated the association between the American Heart Association (AHA) ideal cardiovascular health metrics, including smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol, and fasting blood glucose, and the risk of developing hyperuricemia. Methods. We included 77,787 Chinese adults, ages ‡18 years (60,951 men and 16,836 women), without hyperuricemia at the baseline (2006) in this study. Information on the cardiovascular health metrics at baseline was collected. Incident hyperuricemia cases were identified by elevated serum uric acid concentrations, which were repeatedly assessed in 2006, 2008, 2010, and 2012, respectively. Cox regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for incident hyperuricemia according to the baseline ideal cardiovascular health metrics. Results. We observed an inverse relation between the greater numbers of ideal cardiovascular health metrics at baseline and lower risks of developing hyperuricemia during 6 years of followup. After adjusting for age, sex, alcohol consumption, and other potential confounders, the HRs for incident hyperuricemia were 0.95, 0.84, 0.72, and 0.64 (95% CIs 0.58-0.70, P for trend < 0.0001) for participants who met 2, 3, 4, and 5-7 metrics, respectively, compared with those who met 0-1 cardiovascular health metrics. Conclusion. Greater cardiovascular health metrics were associated with lower risk of hyperuricemia in this Chinese population, suggesting that the modifiable construct defined by the AHA could be of significance in reducing the risk of developing hyperuricemia-related diseases, such as gout.

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Section: Discussionmentioning

confidence: 53%

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

Meng

Huang

et al. 2016

Arthritis Care & Research

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“…Antioxidant properties of uric acid have been attributed to the capacity of reacting with biological oxidants [40]. Thus, the increases observed in this parameter after the padel matches could be a mechanism to face the greater production of reactive oxygen species (ROS) cause by the physical exercise [44]. On the other hand, the increases observed in urea after the SC could be associated with an enhanced protein catabolism due to the game intensity.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Padel Match on Biochemical and Haematological Parameters in Professional Players with Regard to Gender-Related Differences

et al. 2020

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Haematological and biochemical parameters have not yet been analysed in professional padel players. The aim of this study was to determine the basal values of these parameters and to observe the effect of a simulated competition on them, including gender-related differences. A total of 14 male professional players (age: 28.2 ± 7.9 years), and 16 female professional players (age: 29.7 ± 3.7 years) participated in this study. Players were allowed to hydrate ad libitum during the matches. Haematological and biochemical values were obtained before and after a simulated competitive padel match. The men’s group showed higher baseline values in red blood cells, haematocrit, haemoglobin, urea, creatinine, uric acid, albumin, glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), lactate dehydrogenase (LDH) and creatine kinase (CK) (p < 0.01) than the women’s group. Attending to match effect, significant differences were obtained in urea, creatinine, CK and glucose (p < 0.05). Finally, the group x match interaction revealed significant differences in serum concentrations of sodium and chloride (p < 0.05). In conclusion, high-level padel matches provoke several changes in biochemical parameters related to muscle damage and protein catabolism. Recovery and fluid intake strategies could be added regarding gender. The results obtained could be due to the differences in the intensity and volume of the simulated competition.

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“…Similarly to our results, in the study of Nishida et al [ 51 ], moderate intensity PA was inversely correlated with UA level in obese individuals. On the other hand, Beavers et al [ 52 ] identified about 5% higher values of UA in older adults after 12-month moderate intensity PA intervention as compared with subjects who participated only in a successful aging health education intervention. Ideally, exercise training should be able to reduce proinflammatory levels of UA to antioxidant and protective levels.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity, Aerobic Capacity, and Total Antioxidant Capacity in Healthy Men and in Men with Coronary Heart Disease

Gawron-Skarbek

Chrzczanowicz

Kostka

et al. 2015

Oxidative Medicine and Cellular Longevity

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Objective. The purpose of the study was to assess total antioxidant capacity (TAC) of blood serum in relation with habitual leisure time physical activity (LTPA) and aerobic capacity in a group of 90 men with coronary heart disease (CHD) aged 34.8–77.0 years and in 90 age-matched peers without CHD. Methods. Two spectrophotometric methods were applied to assess TAC: Ferric Reducing Ability of Serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. Aerobic capacity was expressed as physical working capacity at 85% of the maximal heart rate (PWC85%HRmax). Results. CHD patients had higher values of TACFRAS (1.37 ± 0.28 versus 1.27 ± 0.23 mmol FeCl2·L−1; P < 0.05) but there were no group differences for TAC-DPPH and for uric acid (UA). Negative correlation was found between LTPA (also when calculated per kg of body mass) and TAC-DPPH in CHD patients. In CHD patients, TAC-FRAS and UA were lower in subjects with higher aerobic capacity expressed as PWC85%HRmax/kg. Those associations were not found in healthy men. Conclusions. We conclude that TAC of blood serum is moderately adversely related to LTPA and aerobic capacity in patients with CHD. UA, as the main determinant of serum TAC, may be partially responsible for those associations.

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The Effects of a Long-Term Physical Activity Intervention on Serum Uric Acid in Older Adults at Risk for Physical Disability

Cited by 12 publications

References 34 publications

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

Ideal Cardiovascular Health Metrics and Incident Hyperuricemia

Effect of a Padel Match on Biochemical and Haematological Parameters in Professional Players with Regard to Gender-Related Differences

Physical Activity, Aerobic Capacity, and Total Antioxidant Capacity in Healthy Men and in Men with Coronary Heart Disease

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