The effects of a high-fat, high-fructose, and combination diet on learning, weight, and glucose regulation in C57BL/6 mice

Messier, Claude; Whately, Katie; Liang, Jacky; Du, Lei; Puissant, David

doi:10.1016/j.bbr.2006.12.011

Cited by 72 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some previous stud ies by Stranahan et al and Brito et al reported that high fructose diets induced weight gain and more drinking liquid in rodents [7,21,27]. Contrary to their claim, in this study, no weight gain and change in liquid intake was observed.…”

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Rafati¹,

Anvari²,

Noorafshan³

2013

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 55%

“…As listed earlier, different admin istration routes and different species of animals may explain the controversy observed [6,21,29].…”

Section: Discussionmentioning

confidence: 99%

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Rafati¹,

Anvari²,

Noorafshan³

2013

View full text Add to dashboard Cite

show abstract

“…This suggests that fructose enters the brain because it is a potent and specific stimulator of GLUT5 transcription (51). Consistent with the controversial nature of this subject, a more recent study found that high fructose diets do not upregulate GLUT5 in the brain (106). Hence, the physiological role of GLUT5 and the effect of high-fructose diets in the brain still need to be investigated.…”

Section: Physiology and Functionmentioning

confidence: 94%

Regulation of the fructose transporter GLUT5 in health and disease

Douard¹,

Ferraris²

2008

American Journal of Physiology-Endocrinology and Metabolism

395

366

View full text Add to dashboard Cite

Fructose is now such an important component of human diets that increasing attention is being focused on the fructose transporter GLUT5. In this review, we describe the regulation of GLUT5 not only in the intestine and testis, where it was first discovered, but also in the kidney, skeletal muscle, fat tissue, and brain where increasing numbers of cell types have been found to have GLUT5. GLUT5 expression levels and fructose uptake rates are also significantly affected by diabetes, hypertension, obesity, and inflammation and seem to be induced during carcinogenesis, particularly in the mammary glands. We end by highlighting research areas that should yield information needed to better understand the role of GLUT5 during normal development, metabolic disturbances, and cancer.

show abstract

“…On the other hand, fructose supplementation has been extensively studied in rodents, especially in rats, and has been shown to promote insulin resistance and inflammation [14,15]. Few mice studies suggest that the metabolic response towards high fructose diets provides discrepant results concerning the effect on body weight, glucose and lipid homeostasis [38][39][40]. Messier et al [39] have shown that the combination of HF diet and fructose supplementation in mice leads to increased weight gain and impairments in blood glucose regulation, but this combination model has not been extensively studied.…”

Section: Page 16 Of 42mentioning

confidence: 99%

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Sohet

Neyrinck

Pachikian

et al. 2009

Biochemical Pharmacology

150

View full text Add to dashboard Cite

Please cite this article as: Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM, Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice, Biochemical Pharmacology (2008Pharmacology ( ), doi:10.1016Pharmacology ( /j.bcp.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Aims:The aim of the study is to investigate the effect of the antioxidant coenzyme Q10 (CoQ10) on hepatic metabolic and inflammatory disorders associated with diet-induced obesity and glucose intolerance.Methods: C57bl6/j mice were fed for 8 weeks, either a control diet (CT) or a high fat diet plus 21% fructose in the drinking water (HFF). CoQ10 supplementation was performed in this later condition (HFFQ).Results HFF mice exhibit increased energy consumption, fat mass development, fasting glycemia and insulinemia and impaired glucose tolerance. HFF treatment promoted the expression of genes involved in reactive oxygen species production (NADPH oxidase), inflammation (CRP, STAMP-2) and metabolism (CPT1) in the liver. CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice. HFF diets paradoxically decreased TBARS (reflecting lipid peroxides) levels in liver, muscle and adipose tissue versus CT group, an effect related to vitamin E content of the diet. Conclusion:In conclusion, HFF model promotes glucose intolerance and obesity by a mechanism independent on the level of tissue peroxides. CoQ10 tends to decrease hepatic stress gene expression, independently of any modulation of lipid peroxidation, which is classically considered as its most relevant effect.

show abstract

The effects of a high-fat, high-fructose, and combination diet on learning, weight, and glucose regulation in C57BL/6 mice

Cited by 72 publications

References 28 publications

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Regulation of the fructose transporter GLUT5 in health and disease

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Contact Info

Product

Resources

About