Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Rafati, Ali; Anvari, Enayat; Noorafshan, Ali

doi:10.5114/fn.2013.37705

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…Certain previous studies reported that HF diets induced weight gain and a higher consumption of liquid in rodents (17,18). The findings of the present research are not in accordance with those of Rafati et al (19), which indicated no difference in body and brain weights, and fluid intake in fructose rats. These discordances may be explained by the different types of fructose administration and different species of experimental animals.…”

Section: Discussioncontrasting

confidence: 57%

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

Madani

Malaisse²,

Ait-Yahia

2015

Biomedical Reports

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Abstract. The present study explored the potential of fish proteins to counteract high glucose levels and oxidative stress induced by fructose in the brain. A total of 24 male Wistar rats consumed sardine protein or casein with or without high fructose (64%). After 2 months, brain tissue was used for analyses. The fructose rats exhibited an increase in body mass index (BMI), body weight, absolute and relative brain weights and brain glucose; however, there was a decrease in food and water intake. Fructose disrupts membrane homeostasis, as evidenced by an increase in the brain hydroperoxides and a decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) compared to the control. The exposure to the sardine protein reduced BMI, food intake, glucose and hydroperoxides, and increased CAT and GSH-Px in the brain. In conclusion, the metabolic dysfunctions associated with the fructose treatment were ameliorated by the presence of sardine protein in the diet by decreasing BMI, brain glucose and lipid peroxidation, and increasing CAT and GSH-Px activities.

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Section: Discussioncontrasting

confidence: 57%

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

Madani

Malaisse²,

Ait-Yahia

2015

Biomedical Reports

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“…They found that 4 weeks of fructose and sucrose consumption (23% solutions) significantly reduced hippocampal neurogenesis, while glucose consumption did not have a reducing effect ( 26 ). Next, Rafati et al ( 27 ) demonstrated that neuronal loss after fructose consumption (10% solution for 6 weeks) was observed in the NTS. Additional research is needed to understand whether the fructose-induced reduction in neurogenesis is associated with altered appetite control and/or cognitive impairment.…”

Section: Fructose and Cognitionmentioning

confidence: 99%

“…Apart from its effects on learning and memory, fructose can also affect neurogenesis as shown in the hippocampus as well as in the nucleus tractus solitarius (NTS) ( 26 , 27 ). Using 5′-bromo-2′-deoxyuridine (BrdU), van der Borght et al ( 26 ) evaluated the amount of newborn neurons in different dietary conditions.…”

Section: Fructose and Cognitionmentioning

confidence: 99%

Effects of High-Fructose Diets on Central Appetite Signaling and Cognitive Function

et al. 2015

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The consumption of fructose has increased tremendously over the last five decades, which is to a large extent due to the development of high-fructose corn syrup (HFCS), a commercial sugar additive that contains high amounts of free fructose. HFCS is often added to processed food and beverages partly because it is a powerful sweetener but even more so because the production is cheap. Although fructose in combination with fiber, vitamins, and minerals, as present in fruits, is a healthy source of energy, isolated fructose, in processed food products has been associated with several health disorders such as insulin resistance and hypertension. Apart from its metabolic consequences, a growing body of literature suggests that free fructose can also affect neuronal systems. High-fructose intake may on the one hand affect central appetite regulation by altering specific components of the endocannabinoid system. On the other hand, it appears to impact on cognitive function by affecting phosphorylation levels of insulin receptor, synapsin 1, and synaptophysin. The present report reviews the recent evidence showing a negative effect of free fructose consumption on central appetite control, as well as cognitive function.

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“…Fructose is a simple sugar with 6 carbons similar to glucose, which differs in spatial pattern with glucose and is found in many fruits and vegetables [6]. It can cause several adverse effects including insulin resistance, dyslipidemia, oxidative stress, neuronal loss, and HP when used in high concentrations [7,8].…”

Section: Introductionmentioning

confidence: 99%

Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis

2020

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High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2-6, 7-10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95% confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high (I2 = 81.3%, p < 0.001) and estimated based on; 1) type of fructose feeding (diet; I2 = 79.3%, solution 10%; I2 = 83.4%, solution 20%; I2 = 81.3%), 2) duration of treatment (2-6 weeks; I2 = 86.8%, 7-10 weeks; I2 = 76.3%, and > 10 weeks; I2 = 82.8%), 3) the animal race (Wistar; I2 = 78.6%, Sprague-Dawley; I2 = 83.9%). Overall, the pooled estimate for the all parameters was significant (p < 0.001). The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption.

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Original article High fructose solution induces neuronal loss in the nucleus of the solitary tract of rats

Abstract: A b s t r a c t Nucleus tractus solitarius (NTS) is the main region for the cardiovascular regulation including

Cited by 13 publications

References 31 publications

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

Effects of High-Fructose Diets on Central Appetite Signaling and Cognitive Function

Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis

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