The effects of 17?-estradiol and ethanol on zinc- or manganese-induced toxicity in SK-N-SH cells

Keller, Jay R.; Owens, Christopher; Lai, James C. K.; Devaud, Leslie L.

doi:10.1016/j.neuint.2004.11.003

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…In addition, it has been reported that some harmful effects attributed to zinc deficiency [24][25][26] may also occur with elevated doses of the metal [27]. In healthy humans, given zinc in amounts five times higher than normal for more than 8 days has been shown to produce a decrease in chemotaxis and phagocytosis [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Upon Human and Murine Cell Viability and Differentiation

Vega-Robledo¹,

Polo-Jiménez²,

Morales-Martinez

et al. 2007

Biol Trace Elem Res

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Most zinc studies show its benefits or changes that coincide with its deficiency, but some have reported damages by supplements. In this work, the effects of zinc in different cell lines (U-937, human monocytes, and murine bone marrow cells) were analyzed. The cells were put in their specific culture medium either alone or with a stimulant [1-phorbol 12-myristate 13-acetate (PMA) for U-937 and monocytes, granulocyte macrophage colony stimulating factor (GM-CSF) for bone marrow cells]. These preparations, with or without zinc (0.05 to 1.0 mM), were incubated and microscopically analyzed on days 3, 9, and 11. The viability of all cells cultivated with 0.05 and 0.1 mM of zinc was similar to that of the controls without zinc (90%). With 1.0 mM of zinc, the viability diminished (p < 0.005) to 80% in U-937 and to 50% in monocytes and bone marrow cells; the number of cells increased in the three lines, but there was no differentiation. We conclude that the effects observed with different doses of zinc vary not only among the different species but also according to the time the cells were exposed to the metal. The same doses of zinc can have either a stimulatory or an inhibitory effect.

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Section: Discussionmentioning

confidence: 99%

Effect of Zinc Upon Human and Murine Cell Viability and Differentiation

Vega-Robledo¹,

Polo-Jiménez²,

Morales-Martinez

et al. 2007

Biol Trace Elem Res

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“…Using the SK-N-SH cells, Keller and colleagues demonstrated that moderate concentrations of estradiol and ethanol protected the cells against the manganese-induced toxicity. In particular, estrogen protection has been speculated through its antioxidant property (Keller et al, 2005). Given the multifactorial nature of AD and clinical senile dementia, the sex dimorphism of the diseases may also depend on factors independent of sex hormones (i.e., a gender behavioral effect).…”

Section: Alcohol Consumption and Risk Of Dementiamentioning

confidence: 99%

Sex difference in alcoholism: Who is at a greater risk for development of alcoholic complication?

2010

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Aims-Alcohol abuse and alcoholism are among the major medical problems afflicting both men and women. While men display a higher prevalence for alcoholism, it is women who suffer a much greater risk for alcoholism-associated bodily damage. Although women generally consume less alcohol compared to men, females usually suffer more severe brain and other organ damage following binge or chronic alcohol abuse. Main methods and key findings: Although many biological (i.e., genetic risk and neurological abnormalities) and psychosocial (i.e., impact of positive drinking expectancies, personality characteristics and deviance proneness) factors appear to impact men and women equally. These factors especially social and environmental, physiological, genetic and neurobiological ones have been demonstrated to contribute to the sex difference in response to alcohol intake, as well as the development of alcoholic complications. A number of neurotransmitters and growth factors may be partially involved in these differences between men and women. The mesolimbic dopamine system is implicated in the development of addictive behaviors. Differences in dopamine receptor density are found between sexes where gonadal steroid hormones may play a role. Inhibitory GABAergic and stimulatory glutamatergic systems also act as neuromodulators in the brain and differences in their specific receptors have been identified between men and women (particularly GABA A receptors and NMDA receptors).Significance-Given the variety of factors contributing to the sex difference in response to alcohol intake, alcoholism treatment should take sex dimorphism into consideration. Furthermore, future research needs to be directed towards a better understanding of the mechanism of action of alcohol in both men and women.

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“…Acid mine drainage (AMD) refers to untreated wastewater from mining activities (Geremias et al, 2003) and poses a threat to human and environmental health (Keller et al, 2005;Lee et al, 2010). AMD contains high concentrations of sulphur and heavy metals (Hughes and Gray, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluating sulphate removal and identifying the bacterial community present in acid mine drainage treated with synthetic domestic wastewater sludge

Berg

Botes

Slabbert

et al. 2016

WSA

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Domestic wastewater sludge can serve as a carbon source in the passive biotic treatment of acid mine drainage (AMD) in microbial bioreactors to create anaerobic conditions for the removal of sulphate, chemical oxygen demand (COD) and pH neutralization. A synthetic medium simulating domestic wastewater sludge was used in AMD treatment in a ratio of 1:1 AMD: synthetic domestic wastewater sludge (SDWWS). Sulphate and COD removal were determined at different incubation temperatures and with and without a biofilm in the bioreactors. Sulphate and COD were removed by 60.8% and 96% within 26 d, after which a plateau was reached. Bacterial community analyses using next generation sequencing showed that Chlorobium spp. dominated at a relative percentage of 36% followed by Magnetospirillum spp. and Ornithobacterium spp. The effect of a resident biofilm in the bioreactors showed dominance of Chlorobium spp. at a relative percentage of 62% and removal of sulphates and COD at 96% and 58%, respectively, after 26 d. Incubation at 17-19°C reduced sulphates by only 10% and COD by 12% after 17 d, after which a plateau was reached. Magnetospirillum spp. was the dominate organism at the end of this trial.

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The effects of 17?-estradiol and ethanol on zinc- or manganese-induced toxicity in SK-N-SH cells

Cited by 8 publications

References 42 publications

Effect of Zinc Upon Human and Murine Cell Viability and Differentiation

Effect of Zinc Upon Human and Murine Cell Viability and Differentiation

Sex difference in alcoholism: Who is at a greater risk for development of alcoholic complication?

Evaluating sulphate removal and identifying the bacterial community present in acid mine drainage treated with synthetic domestic wastewater sludge

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