The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats

Abstract

Background: Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The combination of the two extracts have been known to potentially have a synergistic effect on anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats.
 Methods: Thirty female wistarstrain rats were randomly divided into 5 groups: normal, iron deficiency anemia, Sa, Mo and the combination of Sa and Mo. Beside the normal group, rats were fed Fe-deficient diet to induce iron-deficiency anemia. Level of hemoglobin, ferritin and plasma MDA were measured on day 8 (after induction of anemia) and day 29. Data were analyzed using One Way ANOVA followed by LSD post hoc test.
 Result: The rats fed with Fe-deficient diet for 7 days shown significantly had a lower plasma Hb and ferritin levels and higher plasma MDA levels compared to the normal group (p <0.05) After the treatment, the rats given the extracts significantly had a higher mean of Hb and Ferritin and a lower mean of MDA level compared to anemic control. The mean Hb, ferritin and MDA level of the combination group were close to normal group.
 Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.
 Bangladesh Journal of Medical Science Vol.18(1) 2019 p.136-140

Effect of Moringa Leaf Ethanol Extract on Reduced Levels of Mda, TNF-α and Description of Inflammatory Cells in Rat Sinus Mucosa Model of Acute Rhinosinusitis

“…This may be due to the correlation between the antioxidant components of Androgynous Sauropus extract and moringa leaf extract. 20 In this study it can be concluded that acute bacterial rhinosinusitis, antibiotic therapy as the main therapy coupled with EEDK as adjuvant therapy effectively accelerates the healing process in acute inflammation characterized by a decrease in MDA levels, as a compound that is a marker of the occurrence of oxidative stress, where MDA is an oxidation product of unsaturated fatty acids by free radicals as well as metabolites of cell components produced by free radicals. Seeing high MDA levels indicates the oxidation process in cell membranes, when high antioxidants will usually be followed by a decrease in MDA levels 21 In this study the decrease in MDA levels is due to the presence of antioxidant content in EEDK that can reduce oxidative stress at the time of acute inflammation.…”

Sauropus androgynus (L.) Merr.: a multipurpose plant with multiple uses in traditional ethnic culinary and ethnomedicinal preparations

“…It is not only popular for its nutritional properties, but also for its therapeutic potential [ 39 – 43 ]. It is used to cure several ailments such as fever, urinary problems, ulcers, pain relief, malaria and interestingly they are used to increase the production of breast milk in feeding mothers in various corners of the world [ 24 , 44 , 45 ].…”

“…Siswanto [ 215 ] proved that the ethanolic extract of S. androgynus is effective against anaemia and increase in RBC and haemoglobin was observed in the mice exposed to motorcycle smoke when treated with ethanolic extract (200 mg/kg weight). Indrayani et al [ 39 ] found that combined extract of S. androgynous and M. oleiefera raises the haemoglobin and ferritin in rats. Suparmi et al [ 25 ] also obtained similar results with chlorophyll extract of S. androgynus.…”

Estimation of serum ferritin and TSH levels in thalassemia patients undergoing iron chelation therapy

“…( Table : 3 ) women but menstruating women, in addition, loose highly variable amount of iron . 16,17,18,19,36 The two main sources of chelatable iron are (a) the intracellular liable pool, derived from lysosomal catabolism of ferritin and from transferrin -and non -transferring -bound iron and (b) the iron derived from red cells catabolism in macrophages.To prevent hemosiderosisiron needs to be chelated and excreted. Thechelators are presently in use: desferroxamine (DFO), deferiprone and deferasirox.…”

“…This increased body iron can damage vital organs like heart, pituitary, thyroid,pancreas etc., causing morbidity and mortality. 6,7,25,36 Hypothyrodism is one of the most common endocrine complications in thalassaemics. Serum ferritin estimation reflects serum T.S.H.…”