The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease

Lloret, Ana; Esteve, Daniel; Monllor, Paloma; Cervera‐Ferri, Ana; Lloret, A. Martínez

doi:10.3390/ijms20040879

Cited by 106 publications

(67 citation statements)

References 139 publications

(130 reference statements)

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“…Inflammation and oxidative stress go hand in hand (3) , since reactive oxygen species (and materials such as bacterial cell wall components that can lead to their generation (206,488) ), lead to the production of inflammatory cytokines. Although a great many chronic, inflammatory diseases are recognised as having an oxidative stress component (223) , the history of treating them with antioxidants such as ascorbate has largely been a litany of failure, with the treatment arm often even giving worse prognoses than the placebo (6,223,(489)(490)(491)(492)(493)(494)(495)(496)(497)(498)(499)(500)(501) . Arguably this is because nominally antioxidant molecules such as ascorbate have complex, multi-electron redox chemistry, and can in fact act as pro-oxidants (502,503) , especially in the presence of free Fe (208,213) or Cu (504) .…”

Section: Ergothioneine As a Therapeutic For Chronic Inflammatory Disementioning

confidence: 99%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

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Section: Ergothioneine As a Therapeutic For Chronic Inflammatory Disementioning

confidence: 99%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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“…Therefore, future clinical studies to assess the efficacy of these agents would reveal novel insights regarding the development of novel therapeutic strategies for CAA and AD. Despite continuous efforts to offer antioxidants as potential therapeutic agents for AD, the evidence regarding their ability to slow down AD progression has been inconclusive [95]. Therefore, it is notable that the antioxidant supplement TwX showed beneficial effects in recent preclinical and clinical studies [72][73][74], which supports antioxidative treatment for AD.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…However, the effectiveness of antioxidants, particularly for cognitive decline, seems to be highly sensitive to various factors. One possible reason for this is that reliable biomarkers for oxidative stress have not been established, so it is difficult to distinguish between non-responders and responders by measuring oxidative stress within individuals [95]. Another possibility is the differing bioavailability of antioxidants between individuals.…”

Section: Future Perspectivesmentioning

confidence: 99%

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Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Tanaka

Saitô

Inoue

et al. 2020

IJMS

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Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease directly implicated in Alzheimer’s disease (AD) pathogenesis through amyloid-β (Aβ) deposition, which may cause the development and progression of dementia. Despite extensive studies to explore drugs targeting Aβ, clinical benefits have not been reported in large clinical trials in AD patients or presymptomatic individuals at a risk for AD. However, recent studies on CAA and AD have provided novel insights regarding CAA- and AD-related pathogenesis. This work has revealed potential therapeutic targets, including Aβ drainage pathways, Aβ aggregation, oxidative stress, and neuroinflammation. The functional significance and therapeutic potential of bioactive molecules such as cilostazol and taxifolin have also become increasingly evident. Furthermore, recent epidemiological studies have demonstrated that serum levels of a soluble form of triggering receptor expressed on myeloid cells 2 (TREM2) may have clinical significance as a potential novel predictive biomarker for dementia incidence. This review summarizes recent advances in CAA and AD research with a focus on discussing future research directions regarding novel therapeutic approaches and predictive biomarkers for CAA and AD.

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“…It has shown positive results on cognition. However, further research is required to support the use of vitamin E as a therapeutic agent for AD [126].…”

Section: Vitaminsmentioning

confidence: 99%

Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments

Sharma

Kumar

2019

ADR

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Alzheimer's disease (AD), the 'Plague of Twenty-First Century,' is a crippling neurodegenerative disease that affects a majority of the older population globally. By 2050, the incidence of AD is expected to rise to 135 million, while no treatment(s) that can reverse or control the progression of AD are currently available. The treatment(s) in use are limited in their ability to manage the symptoms or slow the progression of the disease and can lead to some severe side effects. The overall care is economically burdensome for the affected individuals as well as the caretakers or family members. Thus, there is a pressing need to identify and develop much safer alternative therapies that can better manage AD. This review discusses a multitude of such treatments borrowed from Ayurveda, traditional Chinese practices, meditation, and exercising for AD treatment. These therapies are in practice since ancient times and reported to be beneficial as anti-AD therapies. Ayurvedic drugs like turmeric, Brahmi, Ashwagandha, etc., management of stress by meditation, regular exercising, and acupuncture have been reported to be efficient in their anti-AD usage. Besides, a combination of vitamins and natural dietary intakes is likely to play a significant role in combating AD. We conclude that the use of such alternative strategies will be a stepping-stone in preventing, treating, curing, or managing the disease.

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The Effectiveness of Vitamin E Treatment in Alzheimer’s Disease

Cited by 106 publications

References 139 publications

The biology of ergothioneine, an antioxidant nutraceutical

The biology of ergothioneine, an antioxidant nutraceutical

Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments

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