The effectiveness of systemic eradication therapy against oral <i>Helicobacter pylori</i>

Bago, Ivona; Bago, Josip; Plečko, Vanda; Aurer, Andrej; Majstorović, Karolina; Budimir, Ana

doi:10.1111/j.1600-0714.2010.00989.x

Cited by 24 publications

(15 citation statements)

References 35 publications

(44 reference statements)

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“…An interesting study by Bago et al [55] involved 56 patients with UBT-proven H. pylori infection, and 41.1% of patients harbored the bacterium in oral cavity, as detected by PCR. Three months after the triple eradication therapy (PPI twice daily/amoxicillin/clarithromycin), the eradication rate in stomach was 78.3%, and surprisingly, H. pylori was not detected in any sample from oral cavity.…”

Section: Ophthalmology Skin and Oral Mucosa Diseasesmentioning

confidence: 99%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2012

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In the last year, different diseases possibly linked to Helicobacter pylori infection but localized outside of the stomach have been investigated. There are, in fact, several studies concerning cardiovascular diseases, hematologic disorders, neurologic diseases, metabolic, hepatobiliary diseases, and other conditions. Some of those studies, such as those on sideropenic anemia and idiopathic thrombocytopenic purpura, are quite large and well conducted, while in other cases there are just small or isolated studies or even case reports. Nonetheless, there is much interest among researchers all over the world for such a topic as demonstrated by the large number of studies published in the last year.Several articles have been published in the last year concerning the extragastric manifestations of Helicobacter pylori infection. Here we summarize the main results obtained by these studies.

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Section: Ophthalmology Skin and Oral Mucosa Diseasesmentioning

confidence: 99%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2012

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“…Most published studies have aimed to investigate the oral cavity as a source for subsequent gastric infections, which, of course, is an important issue in this field of research (Namiot et al, 2010;Chaudhry et al, 2011;Silva et al, 2010;de Souza Gonçalves et al, 2009;Bago et al, 2011;Eskandari et al, 2010). In contrast to the results presented here, many studies clearly reported the occurrence of H. pylori in dental plaque and concluded that there was an association between gastroesophageal disease and dental oral status (Silva et al, 2009(Silva et al, , 2010; Morales-Espinosa et al, …”

Section: Discussionmentioning

confidence: 60%

Is Helicobacter pylori resident or transient in the human oral cavity?

Al‐Ahmad

Kürschner

Weckesser

et al. 2012

Journal of Medical Microbiology

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Helicobacter pylori colonizes the stomachs of at least half of the world's human population. The role of the oral cavity in this colonization is not clear and there are, to date, no comprehensive data that clearly demonstrate the isolation of this bacterium from the oral cavity. The aim of this study was to evaluate the prevalence of H. pylori in the oral cavity of 15 patients who tested positive for H. pylori. A comprehensive dental examination of all patients was conducted. Samples were taken from supragingival and subgingival plaque, saliva, periapical exudates and tongue swabs. All samples were taken before the application of antibiotics. A total of 163 oral samples were investigated by PCR using two different H. pylori-specific primer pairs. A PCR inhibition control using a modified plasmid was always included for the most specific primer pair. In addition, a culture technique was used to confirm PCR results. Despite a PCR detection limit of 10 2 bacteria ml "1, out of 14 patients, H. pylori could not be detected in any of the samples taken. In one patient, H. pylori-positive PCR signals were obtained in two samples using only one primer pair. H. pylori could not be cultivated from these two PCR-positive samples; therefore, no correlation to oral colonization status could be established. This study challenges the misleading preconception that H. pylori resides in the human oral cavity and suggests that this bacterium should be considered transient and independent of the oral status. To date, positive PCR results for H. pylori in the oral cavity have been overestimated and not critically interpreted in literature.

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“…Присутствие Helicobacter pylori в ротовой поло-сти рассматривают как источник реинфекции сли-зистой оболочки желудка у больных с гастродуоде-нальной патологией после эрадикационной терапии [4,5], так как полость рта является перманентным резервуаром для персистирования Helicobacter pylori [2]. При лечении КПЛ СОР одним из основных эта-пов комплексной терапии, помимо общей терапии, является местное консервативное лечение.…”

Section: Abstract: Lichen Ruber Planus Oral Cavity Mucosa Helicobaunclassified