The effectiveness of structured exercise programmes on psychological and physiological outcomes for patients with psychotic disorders: A systematic review and meta-analysis

Taylor, Caitlin; Tompsett, Claire; Sanders, Ross; Cobley, Stephen

doi:10.1080/1612197x.2018.1519838

Cited by 8 publications

(7 citation statements)

References 72 publications

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“…Psychoeducational or behavioural interventions focusing on healthy lifestyle habits including nutrition, physical activity and sleep practices have been shown to ameliorate both the physical and mental health concerns of young people with psychiatric disorders. [29][30][31][32][33][34] Several studies have administered metformin together with a comprehensive lifestyle intervention containing structured physical activity, nutritional advice or motivational support. 22 35-43 Results from these studies indicate that lifestyle interventions combined with metformin is superior to either intervention alone in reducing weight and BMI.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep–wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: study protocol

et al. 2023

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IntroductionMetformin is a medication likely to improve measures of cardiometabolic disturbance in young people with mental illness. Evidence also suggests metformin may improve depressive symptoms. This 52-week double-blind randomised control trial (RCT) aims to investigate the efficacy of metformin pharmacotherapy as an adjunct to a healthy lifestyle behavioural intervention in improving cardiometabolic outcomes, and depressive, anxiety and psychotic symptoms in youth with clinically diagnosed major mood syndromes.Methods and analysisAt least 266 young people aged 16–25 presenting for mental healthcare for major mood syndromes who are also at risk for poor cardiometabolic outcomes will be invited to participate in this study. All participants will engage in a 12-week sleep–wake, activity and metabolically focused behavioural intervention programme. As an adjunctive intervention, participants will receive either metformin (500–1000 mg) or placebo pharmacotherapy for 52 weeks.Participants will undergo a series of assessments including: (1) self-report and clinician-administered assessments; (2) blood tests; (3) anthropometric assessments (height, weight, waist circumference and blood pressure); and (4) actigraphy. Univariate and multivariate tests (generalised mixed-effects models) will be used to examine changes in primary and secondary outcomes (and associations with predetermined predictor variables).Ethics and disseminationThis study has been approved by the Sydney Local Health District Research Ethics and Governance Office (X22-0017). The results of this double-blind RCT will be disseminated into the scientific and broader community through peer-reviewed journals, conference presentations, social media and university websites.Trial registration numberAustralian New Zealand Clinical Trials Registry (ANZCTR) Number: ACTRN12619001559101p, 12 November 2019.

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Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep–wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: study protocol

et al. 2023

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“…48 49 Additionally, psychoeducation interventions focusing on healthy lifestyle habits including nutrition, physical activity and sleep-wake practices have been shown to ameliorate both the physical and mental health concerns of young people with psychiatric disorders. [50][51][52][53][54] Face-to-face psychoeducation interventions for adults with severe mental illness are able to demonstrate significant improvements in weight 55 ; depressive symptoms, sleep quality and nutrition 56 ; and other cardiometabolic risk factors. 57 Existing web-based psychoeducation intervention studies on adults with mental illness have demonstrated improvements in depression and anxiety symptoms, 58 with mixed evidence on the effect of psychotic symptoms.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Effect of an online healthy lifestyle psychoeducation programme to improve cardiometabolic outcomes and affective symptoms in youth receiving mental health care: study protocol for a pilot clinical trial.

et al. 2021

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IntroductionWorsened cardiometabolic profiles in youth with mental ill health have been associated with a number of modifiable lifestyle risk factors. It is becoming increasingly evident that clinical interventions need to be multimodal in focus to improve mental health symptoms and the physical health symptoms in this already at-risk cohort.Methods and analysisThis 12-week pilot clinical trial examines the efficacy, feasibility and acceptability of an adjunctive online psychoeducation programme for improving cardiometabolic risk parameters and affective symptoms in a transdiagnostic sample of at least 44 young people aged 16–25 years presenting for mental healthcare for mood and/or psychotic syndromes (including anxiety, depression, bipolar disorder and psychosis). Individuals will be invited to participate in a pilot clinical trial for a structured online psychoeducation programme incorporating nutritional, physical activity, sleep–wake and healthy lifestyle information, delivered fortnightly over six online modules. Participants will undergo a series of assessments including: (1) self-report and clinician administered assessments determining mental health symptomatology; (2) fasting blood tests to assess cardiometabolic markers (fasting insulin, fasting glucose and blood lipids); (3) anthropometric assessments (height, weight, waist circumference and blood pressure); and (4) sleep–wake behaviours and circadian rhythm assessments. Changes in scores for all cardiometabolic and affective measures will be assessed via paired samples t-tests, and correlations between change scores will be assessed via Pearson’s or Spearman’s correlations. Feasibility will be assessed via completion rates, and the acceptability of the programme will be assessed via programme satisfaction measures.Ethics and disseminationThis pilot clinical trial has been approved by the Sydney Local Health District Research Ethics and Governance Office (X20-0228 & 2020/ETH01201). The results of this pilot clinical trial will be disseminated into the scientific and broader community through peer-reviewed journals, conference presentations, social media and university websites.Trial registration numberAustralian New Zealand Clinical Trials Registry (ANZCTR) Number: ACTRN12620000772943, Date 28 August 2020.

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“…A fourth meta-analysis [ 18 ] found significant, small-to-moderate effects of mind–body interventions (including yoga, tai-chi, qi-gong, but also mindfulness-based treatment) on negative symptoms among people with schizophrenia. The fifth is the only meta-analysis [ 19 ] investigating the effects of PA interventions among people with any psychotic disorders (including schizoaffective disorders, first episode psychosis, etc.). Significant effects of structured PA training (supervised, controlled, and energy expenditure raising) reduced the level of symptom severity (a combination of negative, positive, and general symptoms).…”

Section: Introductionmentioning

confidence: 99%

“…Significant effects of structured PA training (supervised, controlled, and energy expenditure raising) reduced the level of symptom severity (a combination of negative, positive, and general symptoms). Unfortunately, the differences between people with schizophrenia and people with other psychotic disorder were not tested [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Positive and Negative Symptoms of Psychosis, and General Psychopathology among People with Psychotic Disorders: A Meta-Analysis

Swora

Boberska

Kuliś

et al. 2022

JCM

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Objective: Existing reviews provided evidence for the associations between higher physical activity (PA) and lower negative symptoms of psychosis among people with schizophrenia. This meta-analysis goes beyond existing syntheses and investigates associations between PA, positive and negative symptoms of psychosis, as well as symptoms of general psychopathology (referring mostly to cognitive functioning) among people with schizophrenia, but also other psychotic disorders. The moderating roles of the type of diagnosis and the type of exercise intervention were explored. Methods: The study was registered with PROSPERO (CRD42018118236). Six electronic databases were searched; n = 27 experimental and observational studies were included, and psychotic symptoms-related data were recorded in one direction (higher values indicate better mental health and lower symptomatology). Results: Higher levels of PA (or participating in PA interventions) were associated with better mental health, that is, lower levels of positive symptoms (all studies: r = 0.170; experimental studies: SMD = 0.677), negative symptoms (all studies: r = 0.214; experimental studies: SMD = 0.838), and general psychopathology (all studies: r = 0.451; experimental studies: SMD = 1.511). The type of diagnosis (schizophrenia vs. other psychotic disorders) did not moderate these associations. Conclusions: We found a consistent pattern of associations between higher levels of PA and lower positive, negative, and general psychopathology symptoms in people with schizophrenia and those with other psychotic disorders.

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The effectiveness of structured exercise programmes on psychological and physiological outcomes for patients with psychotic disorders: A systematic review and meta-analysis

Cited by 8 publications

References 72 publications

Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep–wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: study protocol

Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep–wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: study protocol

Effect of an online healthy lifestyle psychoeducation programme to improve cardiometabolic outcomes and affective symptoms in youth receiving mental health care: study protocol for a pilot clinical trial.

Physical Activity, Positive and Negative Symptoms of Psychosis, and General Psychopathology among People with Psychotic Disorders: A Meta-Analysis

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