The effectiveness of rituximab and HIV on the survival of Ontario patients with diffuse large B‐cell lymphoma

Habbous, Steven; Guo, Helen; Beca, Jaclyn; Dai, Wei; Isaranuwatchai, Wanrudee; Cheung, Matthew C.; Chan, Kelvin K.

doi:10.1002/cam4.3362

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Besides, we also found that HIV-associated features, which include CD4 cell count did not affect prognosis of HIV-associated BL. Habbous et al [21] also found that HIV status did not affect prognosis for patients with DLBCL receiving R-CHOP in a general population.…”

Section: Discussionmentioning

confidence: 92%

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HIV‐associated Burkitt lymphoma in the combination antiretroviral therapy era: Real‐world outcomes and prognostication

Wang

Liang

Quan

et al. 2022

eJHaem

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We performed a retrospectively study to analyze the clinical characteristics and outcomes of HIVassociated Burkitt's lymphoma in Chongqing University Cancer Hospital (CUCH), southwest China, from March 2012 to February 2022. In the entire cohort, the median age was 36 years (range, 28-60 years), and more patients were male (82.4%). The median CD4 + T cell count was 214/μl (range, 54-601), of whom 47.1% had a CD4 + T cell count below 200/μl. Most patients had elevated LDH, elevated β 2 -MG, extranodal involvement and advanced Ann Arbor stage at diagnosis. With a median follow-up of 11.5 months (range, 1.6-94.9 months), the overall 1-year PFS and OS rates were 27.6% and 47.6% respectively.The 1-year OS times in the LDH<3 upper limit of normal and LDH≥3 upper limit of normal groups were 62.5% and 31.3%, respectively (p=0.008). The 1-year OS times in the received <4 cycles and ≥4 cycles groups were 0 and 77.8%, respectively (p<0.001). These results demonstrated that LDH<3 upper limit of normal and received ≥4 cycles chemotherapy were signi cantly associated with improved outcomes. However, rituximab administration was not signi cantly associated with improved outcomes.

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Section: Discussionmentioning

confidence: 92%

“…Habbous et al. [ 21 ] also found that HIV status did not affect prognosis for patients with DLBCL receiving R‐CHOP in a general population.…”

Section: Discussionmentioning

confidence: 99%

HIV‐associated Burkitt lymphoma in the combination antiretroviral therapy era: Real‐world outcomes and prognostication

Wang

Liang

Quan

et al. 2022

eJHaem

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“…Основная характеристика ПВЛ -опухолевые выпоты в полостях тела без обнаруживаемых опухолевых масс. Для данных нозологических лимфом Национальная всеобщая онкологическая сеть (NCCN, США) рекомендует общий терапевтический подход (R-EPOCH, R-CHOP) с профилактикой поражения ЦНС метотрексатом и цитарабином с активным наблюдением на момент развития инфекционных осложнений [20,[22][23][24][25][26].…”

Section: первичная выпотная лимфомаunclassified

HIV-associated lymphomas

Дудина

Mabudzada

Ogannisyan

et al. 2023

Kreativnaâ hirurgiâ i onkologiâ

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A steady worldwide increase in the number of people living with HIV (PLHIV) and diagnostic methods requires a separate review of patient-specific nosologies, including lymphoproliferative diseases, some of which are directly associated with the virus due to its oncogenic effect and those that do not relate directly to HIV but introduce nuances to diagnostic and therapeutic approaches when a patient is HIV-positive. Towards this, the paper generally reviews lymphomas in PLHIV, presents the WHO classification of HIV-associated lymphomas, describes a contemporary view of the known mechanisms of pathogenesis, including the role of opportunistic infections, and general principles of diagnostic and therapeutic tactics, provides recommendations on modifying the doses of chemotherapy correlated with the immune status and on preventing CNS involvement. Specific types of lymphoma (Burkitt’s lymphoma, diff use large B-cell lymphoma) are considered separately, including those most frequently associated with patients living with HIV (primary effusion lymphoma, plasmablastic lymphoma, primary central nervous system lymphoma), but rare in the uninfected population.

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Current issues in the management of patients with HIV infection and rheumatic diseases

Гриднева¹,

Белов²

2021

Sovremennaâ revmatologiâ

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According to experts, the human immunodeficiency virus (HIV) epidemic has a steady downward trend, but the attention of the medical community to this problem is not waning. Before the introduction of highly active antiretroviral therapy, the prevalence of rheumatic manifestations in HIV-infected patients ranged from 3 to 71% and was associated with late stages of infection and severe immunosuppression. HIV-associated arthritis, reactive arthritis, psoriatic arthritis, arthralgias and diffuse infiltrative lymphocytosis syndrome are the most common rheumatic pathologies in HIV. Most people with HIV and musculoskeletal inflammatory disease respond well to NSAIDs, opioids, and basic anti-inflammatory drugs. In cases that are torpid to the abovementioned treatment, the use of biologic disease-modifying antirheumatic drugs may be required.The lecture summarizes modern data on the features of the course and treatment of immunoinflammatory rheumatic diseases in HIV infection.

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The effectiveness of rituximab and HIV on the survival of Ontario patients with diffuse large B‐cell lymphoma

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 34 publications

HIV‐associated Burkitt lymphoma in the combination antiretroviral therapy era: Real‐world outcomes and prognostication

HIV‐associated Burkitt lymphoma in the combination antiretroviral therapy era: Real‐world outcomes and prognostication

HIV-associated lymphomas

Current issues in the management of patients with HIV infection and rheumatic diseases

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