The effectiveness of questionnaires in the determination of Contact Lens Induced Dry Eye

Michel, Martina; Sickenberger, Wolfgang; Pult, Heiko

doi:10.1111/j.1475-1313.2009.00658.x

Cited by 43 publications

(23 citation statements)

References 30 publications

(75 reference statements)

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“…Each subject's symptoms were evaluated by a validated Chinese translation of the OSDI questionnaire (10,16,17). Total OSDI scores were calculated as recommended by Schiffman et al (17).…”

Section: Study Protocol Ocular Surface Disease Index (Osdi)mentioning

confidence: 99%

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

Zhang

Huang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland. Meibomian gland loss (MGL) on the upper lid was evaluated using noncontact meibography. The first NITBUT (NITBUTf) was significantly shorter than the average NITBUT (NITBUTav; Mann-Whitney U-test, P<0.01). There was a weak negative Spearman correlation between NITBUTf and OSDI (rs=-0.251, P=0.046) as well as between NITBUTav and OSDI (rs=-0.250, P=0.046). Furthermore, MGL showed a statistically significant Spearman correlation with OSDI (rs= 0.562; P<0.01). In the MGD group, NITBUTf was significantly shorter (P<0.01), and MGL and OSDI score were significantly greater (P<0.01 and <0.01, respectively) than in the control group. In the MGD group, the first tear film break-up point was most frequently located in the inferonasal quadrant, while it was most frequently located in the supertemporal quadrant in the control group, and there was a significant difference with this regard (χ 2 =3.937, P=0.047). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P= 0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ 2 =0.525, P=0.469). In the MGD group, there were significantly more breakups in the lower quadrant than in the upper quadrant (P=0.011), whereas no differences in the number of breakups in each quadrant were observed in the control group (P= 0.429). Furthermore, there was no significant difference in the breakups in the lower quadrants of the two groups (χ 2 =0.525, P=0.469). As the NITBUTs showed only a weak correlation with OSDI, they may not be a strong indicator of the OSDI. However, MGL indicated changes of meibomian gland morphology in the MGD group and the first tear film break-up point was likely located in the inferonasal quadrant in the MGD group.

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“…Each subject's symptoms were evaluated by a validated Chinese translation of the OSDI questionnaire (10,16,17). Total OSDI scores were calculated as recommended by Schiffman et al (17).…”

Section: Study Protocol Ocular Surface Disease Index (Osdi)mentioning

confidence: 99%

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

Zhang

Huang

et al. 2017

Experimental and Therapeutic Medicine

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“…15,20 Ocular Surface Disease Index Each subject's symptoms were evaluated after objective observation by a validated German translation of the OSDI questionnaire. 49 Total OSDI scores were calculated as recommended by Schiffman et al: 3 OSDI ¼ sum of scoresÂ25 number of questions answered…”

Section: Lid-wiper Epitheliopathy (Lwe)mentioning

confidence: 99%

The relationship between clinical signs and dry eye symptoms

Pult

Purslow

Murphy

2011

Eye

146

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Purpose To evaluate (i) the relationship between traditional and new clinical tests (lid-wiper epitheliopathy (LWE), lid-parallel conjunctival folds (LIPCOF)) and dry eye symptoms in non-contact lens wearers, and (ii) that a combination of these tests can improve predictive ability for the development of dry eye symptoms. Methods Tear meniscus height (TMH), non-invasive break-up time (NIBUT), ocular hyperaemia, LIPCOF, phenol red thread test (PRTT), corneal and conjunctival staining, and LWE grades were observed in a cohort of 47 healthy, non-lens wearers (male ¼ 17, female ¼ 30, median age ¼ 35 years, range ¼ 19-70). Symptoms were assessed using the Ocular Surface Disease Index (OSDI). Results LWE was significantly correlated to both temporal and nasal LIPCOF (0.537or o0.607, Po0.05). LIPCOF and LWE were significantly correlated to NIBUT and PRTT (r4À0.248, Po0.001). Significant correlations were found between NIBUT and TMH (r ¼ 0.461, P ¼ 0.001) and PRTT (r ¼ 0.640, Po0.001). OSDI scores were significant correlated to NIBUT, TMH, PRTT, LIPCOF, and LWE (r4|0.31|; Po0.05). Significant discriminators of OSDI þ /À were NIBUT (area under the receiver operative characteristic curve (AUC) ¼ 0.895), TMH (0.715), PRTT (0.781), LIPCOF (temporal/nasal/Sum 0.748/0.828/0.816), and LWE (0.749). Best predictive ability was achieved by combining NIBUT with nasal LIPCOF (AUC ¼ 0.944). Conclusions The individual tests NIBUT, TMH, PRTT, LIPCOF, and LWE were significantly, but moderately, related to OSDI scores. The strongest relationship appeared by combining NIBUT with nasal LIPCOF.

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“…Improvement in visual acuity and relief from symptoms and signs was observed in all cases (100%). Soft contact lenses were found satisfactory in protecting the dry cornea and conjunctiva 8 .…”

Section: Discussionmentioning

confidence: 93%

Therapeutic uses of Soft Contact Lenses

Bajaj¹,

Singh²

2016

jmscr

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Soft contact lenses are widely used for correction of refractive errors and in diseases related to corneal surface irregularities. In this case series we have used soft contact lenses in treatment of patients having bullous keratopathy, corneal ulcer, dry eye, trichiasis and corneal perforation. Soft contact lenses were found to be superior than conventional method of treatment and they have revolutionized the management of corneal diseases. Visual improvement was found to be satisfactory in all cases along with definite improvement of symptoms in cases of corneal surface irregularities.

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The effectiveness of questionnaires in the determination of Contact Lens Induced Dry Eye

Cited by 43 publications

References 30 publications

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

A novel noninvasive ocular surface analyzer for the assessment of dry eye with Meibomian gland dysfunction

The relationship between clinical signs and dry eye symptoms

Therapeutic uses of Soft Contact Lenses

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