The effectiveness of pure Stichopus horrens extract toothpaste in reducing plaque-induced gingivitis following orthodontic bonding: A triple-blinded randomized controlled trial

Bakar, Noraini Abu; Jayah, Nurul Idayu; Mohamed, Nurul Rafhana; Ali, Suhaila Muhammad; Nasir, Siti Hajjar; Hashim, Rosnani; Kharuddin, Azrul Fazwan

doi:10.1016/j.ejwf.2019.11.004

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…But it should be noted that even though in our study patients used similar toothpaste and mouthwashes for several months their oral hygiene levels characterized with reliable differences during each month of monitoring. Such outcome supported evidences regarding dependencies of oral hygiene level on the usage of specifi c toothbrush and mechanical cleaning items, but not on using peculiar toothpaste [25,26].…”

Section: Discussionsupporting

confidence: 72%

Improvement of self-performed oral hygiene among patients with braces and micro-implants: approbation of specifically designed plaque-controlled regime

Volinska¹,

Коваленко

Kaniura

2023

UDJ

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Background. Braces and micro-implants may serve as retention points for the dental plaque under the condition of insufficient everyday oral care, thus compromising oral hygiene level of orthodontic patients. Objective. The assess changes of oral hygiene among orthodontic patients with braces and micro-implants during the use of adapted specifically-designed plaque-controlled regime of self-performed oral hygiene measures. Material and Methods. Study group was formed out of 30 patients aged 18 to 50 years, who were planned to undergo orthodontic treatment with brace system and micro-implant. During the first month of orthodontic treatment patients used a toothbrush with thin bristles, during the second month – V-toothbrush, and during the third month – a two-row and monobundle toothbrush. The interdental hygiene was provided by the size-adjusted toothbrushes. Clinical assessment was provided with the use of hygienic indices (O’Leary, Green-Vermillion and Turesky). Results. At the period of first month after orthodontic treatment initiation O’Leary index increased abruptly to 52.6±6.4%, which stands for unsatisfactory oral hygiene level. Values of Turesky and Green-Vermillion indices increased twofold after orthodontic appliance attachment, and after first month of treatment their values were 1.98±0.31, and 2.12±0.34 points, respectively; while after third month of treatment – 0.99±0.1 and 1.19±0.14, respectively. Conclusions. Oral hygiene conditions were deteriorated among all patients, compared to the pre-treatment situation, which was caused by orthodontic appliances fixation. Oral hygiene of the patients with fixed orthodontic appliances should include usage of two-row toothbrush, which most efficiently clean the plaque above and under the brace arch; and a mono-bundle toothbrush for additional cleaning around brace locks, in gingival area, and around micro-implants.

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Section: Discussionsupporting

confidence: 72%

Improvement of self-performed oral hygiene among patients with braces and micro-implants: approbation of specifically designed plaque-controlled regime

Volinska¹,

Коваленко

Kaniura

2023

UDJ

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“…The extracts of Holothuria forskali and Parastichopus tremulus are reported to inhibit inflammation in endothelial cells ( Mena-Bueno et al, 2016 ). In a triple-blinded randomized controlled trial, the Stichopus horrens extract toothpaste can alleviate plaque-induced gingivitis, suggesting the anti-inflammatory effect of the sea cucumber compounds in human ( Bakar et al, 2020 ). The oligopeptides obtained from A. japonicus and A. leucoprocata may supress inflammatory response via inhibiting Toll-like receptor 4/myeloid differentiation factor 88/NF-κB signalling pathway ( Wan et al, 2020 ).…”

Section: The Sea Cucumber-devived Coumpounds For Treatment Of Cardiac...mentioning

confidence: 99%

Sea cucumber-derived compounds for treatment of dyslipidemia: A review

et al. 2022

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Dyslipidemias are disorders of plasma levels of lipids, such as elevated levels of total cholesterol and triglyceride, that are associated with various human diseases including cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Statins are the first-line drugs for treatment of dyslipidemia. However, a substantial proportion of patients cannot reach the recommended LDL-c level even with the highest tolerated doses of statins, and there is no available drug specifically for NAFLD therapy. Sea cucumbers are one of the widely distributed invertebrates, and are an important resource of food and medicine. Sea cucumbers have many valuable nutrients including saponins, fatty acids, phospholipids, cerebrosides, sulfated polysaccharides, as well as proteins and peptides. In recent years, these natural products derived from sea cucumbers have attracted attentions for treatment of CVD and NAFLD because of their lipid-lowering effect and low toxicity. However, the hypolipidemic mechanisms of action and the structure-activity relationship of these bioactive components have not been well-documented in literature. This review article summarizes the signaling pathways and the potential structure-activity relationship of sea cucumber-derived bioactive compounds including saponins, lipids, carbohydrates as well as peptides and proteins. This article will provide information useful for the development of sea cucumber-derived lipid-lowering compounds as well as for investigation of hypolipidemic compounds that are derived from other natural resources.

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“…Moreover, sea cucumber Stichopus horrens (SH) extracts can promote gingival tissue healing in addition to its anti-streptococcal ability. A study by Bakar et al ( 67 ) showed that a 9% concentration of SH-containing toothpaste (SHCT) was effectively in reducing gingival inflammation (14 days of continuous use) and probe bleeding (30 days of continuous use). The anti-inflammatory effect was also observed with Enteromorpha linza , a green algae whose extract strongly inhibited the growth of Prevotella intermedia and Porphyromonas gingivalis ( 68 ).…”

Section: Research Progress On Marine Bioactive Compounds In Oral Healthmentioning

confidence: 99%

Marine Bioactive Compounds as Nutraceutical and Functional Food Ingredients for Potential Oral Health

et al. 2021

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Oral diseases have received considerable attention worldwide as one of the major global public health problems. The development of oral diseases is influenced by socioeconomic, physiological, traumatic, biological, dietary and hygienic practices factors. Currently, the main prevention strategy for oral diseases is to inhibit the growth of biofilm-producing plaque bacteria. Tooth brushing is the most common method of cleaning plaque, aided by mouthwash and sugar-free chewing gum in the daily routine. As the global nutraceutical market grows, marine bioactive compounds are becoming increasingly popular among consumers for their antibacterial, anti-inflammatory and antitumor properties. However, to date, few systematic summaries and studies on the application of marine bioactive compounds in oral health exist. This review provides a comprehensive overview of different marine-sourced bioactive compounds and their health benefits in dental caries, gingivitis, periodontitis, halitosis, oral cancer, and their potential use as functional food ingredients for oral health. In addition, limitations and challenges of the application of these active ingredients are discussed and some observations on current work and future trends are presented in the conclusion section.

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The effectiveness of pure Stichopus horrens extract toothpaste in reducing plaque-induced gingivitis following orthodontic bonding: A triple-blinded randomized controlled trial

Cited by 6 publications

References 19 publications

Improvement of self-performed oral hygiene among patients with braces and micro-implants: approbation of specifically designed plaque-controlled regime

Improvement of self-performed oral hygiene among patients with braces and micro-implants: approbation of specifically designed plaque-controlled regime

Sea cucumber-derived compounds for treatment of dyslipidemia: A review

Marine Bioactive Compounds as Nutraceutical and Functional Food Ingredients for Potential Oral Health

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