The effectiveness of platelet concentrations in periodontal surgeries

Abstract

Platelets release several growth factors which stimulate tissue regeneration. Several techniques for platelet concentrates such as platelet rich plasma (PRP), plasma rich in growth factors (PRGF), platelet rich fibrin (PRF) and concentrated growth factors (CGF) have been introduced in dental surgeries for the prevention of hemorrhage and acceleration of tissue regeneration. However, a fabricating growth factors-enriched bone graft matrix which is called “sticky bone” has been demonstrated to provide stabilization in bony defects. In this article, we presented the method of preparing and utilizing CGF and sticky bone and evaluate the effect of CGF mixed with bone graft and CGF barrier membrane in periodontal surgeries.Methodology: We used websites such as PubMed, Scopus, and ISI Web of knowledge to get related articles about this subject. The research process involved specific key words " concentrated growth factor”- “Platelet rich fibrin”- growth factors-enriched bone graft” - “sticky bone” to find more articles which published from 2007 to March 2018.Results: We reviewed 48 articles, 43 articles were excluded. Only five articles have been conducted. Original human studies and case report were included.Conclusion: We concluded that the use of sticky bone and CGF is effective in bone grafting and implant.

The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis

“…PRP is the first generation of APCs; it contains a high concentration of platelets obtained by special centrifugation from fresh whole blood. It is required to induce fibrin polymerization by chemical additives including anticoagulant, thrombin, or calcium chloride before applying to the surgical site [9]. PRF is the second generation of APCs originally proposed by Choukroun et al [10] based on the PRP.…”

Guided Bone Regeneration with Concentrated Growth Factor Enriched Bone Graft Matrix (Sticky Bone) vs. Bone-Shell Technique in Horizontal Ridge Augmentation: A Retrospective Study

“…In the attempt to overcome these limitations, CGF-enriched bone graft matrix (sticky bone) has been proposed as an enhancement of standard GBR technique [22]. Sticky bone has been defined as a frame, composed of bone particles and concentrated growth factors [43]. The mechanical properties of this aggregate facilitate its placement and stabilisation in the bone defect, where it can be moulded into the desired shape [26,43].…”

“…Sticky bone has been defined as a frame, composed of bone particles and concentrated growth factors [43]. The mechanical properties of this aggregate facilitate its placement and stabilisation in the bone defect, where it can be moulded into the desired shape [26,43].…”

Injectable platelet-rich fibrin polymerized with hydroxyapatite bone graft for the treatment of three-wall intrabony defects: A randomized control clinical trial

“…From their evolution since the late 1990s, platelet concentrates have gained considerable attention due to their autologous nature as well as potential to get favorable regenerative outcomes. [ 11 , 12 ] The journey of platelet concentrates has come far from platelet-rich plasma (PRP), followed by the focus on the next generation of platelet concentrates, i.e., platelet-rich fibrin (PRF), upto the latest advanced PRF (A-PRF) and liquified form, i.e., injectable PRF (i-PRF). [ 13 - 15 ] These platelet concentrates promote wound healing of soft and hard tissues by providing accelerated growth factors that improve cell proliferation and upregulated angiogenesis.…”