The effectiveness of<i>Hedyotis diffusa</i>Willd extract in a mouse model of experimental autoimmune prostatitis

Wazir, Junaid; Ullah, Rahat; Khongorzul, Puregmaa; Hossain, Amir; Khan, Muhammad Sohail; Aktar, Nasrin; Cui, Xingxing; Zhou, Xiaohui

doi:10.1111/and.13913

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…HDW is also a well-known TMC with a variety of activities, especially its anticancer effect in the clinic [ 24 ]. The latest study demonstrated that HDW significantly reduced inflammatory lesion and inflammatory cell infiltration in a mouse model of experimental autoimmune prostatitis [ 25 ]. In addition, HDW as a complementary therapy is important for the treatment of advanced nasopharyngeal carcinoma patients [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Prescription of Sageretia hamosa Brongn Relieved Goiter through Promoted Apoptosis of Thyroid Cells via miR-511-3p and PTEN/PI3K/Akt Pathway

Deng

Wang

et al. 2021

Journal of Healthcare Engineering

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Goiter is thyroid enlargement, in China, Sageretia hamosa Brongn (SHB) can be used to treat goiter, but it has not been reported. Therefore, data analytics of SHB prescription on thyroid were explored in this study to provide a theoretical support for SHB in the treatment of goiter. In this study, rat in goiter model was constructed by using propylthiouracil (PTU) and treated with SHB prescription. Thyroid function about the triiodothyronine (T3), free thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were measured by ELISA; thyroid coefficient was calculated after weighed thyroid; and HE staining was applied to assess the morphology of thyroid tissue. miRNA microarrays were employed to detect miRNA expression in thyroid tissue of rats. Expression of miR-511-3p was measured by RT-qPCR; expression of proteins (PTEN and apoptosis-related proteins) was tested by western blotting; relationship between miR-511-3p and PTEN was investigated by dual luciferase reporter gene assay; cell viability rate was determined by CCK-8; and cell cycle distribution and apoptosis rate were detected by flow cytometry. The results showed that SHB prescription ameliorated goiter and downregulated miR-511-3p. miR-511-3p targeted PTEN in thyroid cells and PTEN negatively regulated the activation of PI3K/Akt pathway. Furthermore, the inhibition of apoptosis in thyroid cells caused by the overexpression of miR-511-3p or the activation of PI3K/Akt pathway was reversed by treatment of SHB prescription, inhibition of miR-511-3p, or overexpression of PTEN. In conclusion, SHB prescription promoted apoptosis of thyroid through decreased miR-511-3p and regulated PTEN/PI3K/Akt pathway, it might suggest possible medical applications.

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Section: Discussionmentioning

confidence: 99%

Prescription of Sageretia hamosa Brongn Relieved Goiter through Promoted Apoptosis of Thyroid Cells via miR-511-3p and PTEN/PI3K/Akt Pathway

Deng

Wang

et al. 2021

Journal of Healthcare Engineering

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“…Wazir et al showed that the water extract of H. diffusa effectively improved the urination symptoms, relieved pain, and enhanced the inflammatory response in an experimental autoimmune prostatitis mouse model, which might be mediated by the downregulation of the proinflammatory factor TNF-α. [31] The two abovementioned Chinese medicines both have catharsis effects. In addition, red ginseng is beneficial to the Qi and blood, strengthening the heart and spleen, and is often used in patients with deficiency syndrome.…”

Section: Acupuncture Therapymentioning

confidence: 99%

Traditional Chinese medicine regulates inflammatory factors in chronic prostatitis/chronic pelvic pain syndrome: A review

Wang¹,

Zhao²,

Zhang³

et al. 2023

Integr Med Nephrol Androl

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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common male urological disease, and its clinical manifestations are closely related to the dysregulation of inflammatory factors. Nonsteroidal anti-inflammatory drugs have been shown to be effective in managing inflammation and providing pain relief, but their clinical application remains controversial. Traditional Chinese medicine (TCM) is widely used to regulate inflammatory factors in CP/CPPS, and treatment with TCM has gained some advantages based on an “individualized” or “personalized” medical approach. In addition, TCM extracts and acupuncture therapy have also been proven to be effective for CP/CPPS, as they regulate related inflammatory factors. However, current systematic reviews tend to verify the efficacy and safety of TCM therapies in CP/CPPS, and there is still a deficiency in sorting out their mechanisms of modulating inflammatory factors. Based on the current evidence, our review summarizes the application of TCM in regulating inflammatory factors in CP/CPPS to provide a reference for the treatment of CP/CPPS with TCM therapy and a potential direction with future studies in this field.

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“…These therapies have proven efficacies in treating urological disorders (Moran et al, 2013), but the outcomes in UCPPS patients are variable. While there are several animal studies suggesting the potential benefits of herbal therapies for IC/BPS treatment (Cui et al, 2020;Tokita et al, 2023;Wazir et al, 2021;, there were only a few well-designed clinical trials with appropriate controls and sample sizes to provide definitive conclusions about their therapeutic effects. Therefore, future translational and clinical research on the mechanisms of the herbal substances' action and their efficacy for UCPPS patients is warranted (Dashdondov et al, 2021).…”

Section: Botulinum Toxin a (Botn-a) Injections In The Urinary Bladder...mentioning

confidence: 99%

Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions

Ashraf,

Clarkson,

Malykhina

2024

J Pharmacol Exp Ther

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Urologic Chronic Pelvic Pain Syndrome (UCPPS) is a painful chronic condition with persistent pain originating from the pelvis that often leads to detrimental lifestyle changes in the affected patients. The syndrome develops in both sexes, with an estimated prevalence of 5.7% to 26.6% worldwide. This narrative review summarizes currently recommended therapies for UCPPS, followed by the latest animal model findings and clinical research advances in the field. The diagnosis of UCPPS by clinicians has room for improvement despite the changes in the past decade aiming to decrease the time to treatment. Therapeutic approaches targeting growth factors (i.e., NGF, VEGF), amniotic bladder therapy and stem cell treatments gain more attention as experimental treatment options for UCPPS. The development of novel diagnostic tests based on the latest advances in urinary biomarkers would be beneficial to assist with the clinical diagnosis of UCPPS. Future research directions should address the role of chronic psychological stress and the mechanisms of pain refractory to conventional management strategies in UCPPS etiology. Testing the applicability of cognitive behavioral therapy in this cohort of UCPPS patients might be promising to increase their QoL. The search for novel lead compounds and innovative drug delivery systems requires clinically relevant translational animal models. The role of autoimmune responses triggered by environmental factors is another promising research direction to clarify the impact of the immune system in UCPPS pathophysiology. SIGNIFICANCE STATEMENTThis minireview provides an up-to-date summary of the therapeutic approaches for UCPPS with focus on recent advancements in the clinical diagnosis and treatments of the This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward.

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The effectiveness ofHedyotis diffusaWilld extract in a mouse model of experimental autoimmune prostatitis

Cited by 16 publications

References 37 publications

Prescription of Sageretia hamosa Brongn Relieved Goiter through Promoted Apoptosis of Thyroid Cells via miR-511-3p and PTEN/PI3K/Akt Pathway

Prescription of Sageretia hamosa Brongn Relieved Goiter through Promoted Apoptosis of Thyroid Cells via miR-511-3p and PTEN/PI3K/Akt Pathway

Traditional Chinese medicine regulates inflammatory factors in chronic prostatitis/chronic pelvic pain syndrome: A review

Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions

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