The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review

Potting, Carin; Uitterhoeve, Ruud; Reimer, Wilma Scholte op; Achterberg, Theo van

doi:10.1111/j.1365-2354.2006.00684.x

Cited by 71 publications

(43 citation statements)

References 30 publications

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“…2,15,17,18 Chlorhexidine mouthwash has been widely used for the aforementioned purpose because of its well-recognized antimicrobial activity as a topical prophylactic agent against oral mucositis. [13][14][15]17,18 In our case report, the patient rinsed twice daily for one minute with 10 mL of 0.12% chlorhexidine gluconate in order to control the biofilm formation chemically during all the treatment phase. 13 Twicedaily mouthrinses with a solution of 0.12% chlorhexidine gluconate has been shown to minimize oral complications during chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia

Santos

Pochapski

Pilatti

et al. 2009

Australian Dental Journal

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Background: Leukaemia is a malignant neoplasm characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic patients can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. Methods: This case report describes severe maxillary and mandibular necrotizing stomatitis and osteomyelitis in a young female patient after chemotherapy for acute leukaemia. On physical examination, the patient presented malnourished with pale skin, cervical lymphadenitis, frequent fever and generalized pain. The intra-oral clinical examination found halitosis, multiple ulcers, necrotizing stomatitis and osteomyelitis located in the maxillary and mandibular regions. The necrotizing stomatitis and osteomyelitis were treated locally with atraumatic removal of the necrotized tissues. The patient received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of chlorhexidine. She was also treated with systemic metronidazole and amoxicillin for 21 days. Results: During the course of management the patient's oral condition improved with some re-epithelialization being noted. However, severe alveolar bone destruction remained evident. Thirty-two months after presentation of the initial symptoms, the patient died due to complications related to leukaemia recurrence (haemorrhage, sepsis and respiratory distress syndrome). Conclusions: Dental monitoring during cancer treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

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Section: Discussionmentioning

confidence: 99%

Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia

Santos

Pochapski

Pilatti

et al. 2009

Australian Dental Journal

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“…In addition, rinses with povidone iodine reduce the severity of OM. [27] Anti-inflammatory agents, such as benzydamine, are used for both prevention and management of OM. Intravenous immunoglobulins and histamine gels can be used to prevent OM.…”

Section: Oral Mucositismentioning

confidence: 99%

Chemotherapy: oral side effects and dental interventions. A review of the literature

Poulopoulos¹,

Papadopoulos²,

Andreadis³

2017

SDS

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Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patients' quality of life. The aim of this review is to isolate and describe the oral side effects arising only from chemotherapy and focus on the dentist's contribution to their management. This paper comprises an extensive literature review of the main side effects affecting the oral health status of patients' undergoing chemotherapy procedures. In addition, it describes the dentist's contribution in the treatment of such patients before, throughout and after antineoplastic therapy. In conclusion, the oral cavity is a usual site of discomfort and pain caused by chemotherapy, making the dentist's contribution to the patient's relief imperative. Key words:Chemotherapy, oral side effects, oral mucositis, oral infections ABSTRACTArticle history:

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“…Several studies have reported that gargling with antioxidants, cryotherapy in which the development of free radicals in the oral cavity is prevented by reducing oral mucosal transfer of anticancer agents, and maintenance of a clean oral cavity achieved specific effects. [7][8][9][10] However, it is difficult to prevent and treat chemotherapyinduced mucositis, and symptomatic therapy is mainly performed in clinical practice. Thus, strategies against chemotherapy-induced mucositis should be established.…”

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confidence: 99%

Effect of Eriobotrya japonica Seed Extract on 5-Fluorouracil-Induced Mucositis in Hamsters

Takuma

Sun

Yokota

et al. 2008

Biological & Pharmaceutical Bulletin

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Frequent/massive administration of anticancer agents frequently causes mucositis. This condition involves the entire oral cavity in many cases, inducing pain and hemorrhage. Therefore, it decreases dietary intake, markedly reducing the quality of life (QOL). [1][2][3] In addition, severe mucositis influences the administration schedule of anticancer agents, affecting cancer treatment. Thus, it is important to prevent and treat chemotherapy-induced mucositis.Chemotherapy-induced mucositis is associated with two factors. [4][5][6] First, free radicals produced by anticancer agents act on the oral mucosa as oxidative stress, destroying the mucosal tissue and causing mucositis. Secondly, the oral cavity enters an infection-prone state via the bone marrow-suppressing effects of anticancer agents, resulting in mucositis via bacterial infection. However, actually, these two factors may be intricately involved. Therefore, it is important to inhibit excessive anticancer agent-related oxidative stress and prevent bacterial infection in the oral cavity, for the prevention and treatment of mucositis.Currently, chemotherapy-induced mucositis is being investigated in clinical practice. Several studies have reported that gargling with antioxidants, cryotherapy in which the development of free radicals in the oral cavity is prevented by reducing oral mucosal transfer of anticancer agents, and maintenance of a clean oral cavity achieved specific effects. [7][8][9][10] However, it is difficult to prevent and treat chemotherapyinduced mucositis, and symptomatic therapy is mainly performed in clinical practice. Thus, strategies against chemotherapy-induced mucositis should be established.Eriobotrya japonica seed extract (ESE), which was used in this study, was extracted from Eriobotrya japonica seeds with 70% EtOH. We previously confirmed that this extract contained various substances such as polyphenols, amino acids, and unsaturated fatty acids 11,12) ( Fig. 1). Furthermore, an in vitro study demonstrated the radical-scavenging actions of ESE. 11) In several in vivo studies, ESE was useful for treating rats with dimethylnitrosamine-induced hepatopathy, a rat nephropathy model prepared by administering adriamycin, an anticancer agent, and a rat inflammation model prepared by administering lipopolysaccharide comprising Gram-negative bacteria. We confirmed that these effects were achieved via the antioxidant actions of ESE. 12-14)These results suggest that ESE exhibits antioxidant and anti-inflammatory actions, and that this extract is useful for treating chemotherapy-induced mucositis. In this study, we investigated the effects of ESE using a hamster mucositis model prepared by 5-fluorouracil (5-FU) administration. MATERIALS AND METHODS MaterialsSufficiently sun-drided seeds of Mogi-loquant collected at Muroto and Susaki cities in Kochi Prefecture and Shimotsucho in Wakayama Prefecture of Japan were used. 5-Fluorouracil (5-FU) was provided by Kyowahakko (Japan). All other chemicals were of reagent grade.Preparation of ESE Eriobotrya...

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The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review

Cited by 71 publications

References 30 publications

Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia

Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia

Chemotherapy: oral side effects and dental interventions. A review of the literature

Effect of Eriobotrya japonica Seed Extract on 5-Fluorouracil-Induced Mucositis in Hamsters

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