The effectiveness of arginine vasopressin and sodium salicylate as antipyretics in the Brattleboro rat

Dm, Fyda; Wb, Mathieson; Ke, Cooper; Wl, Veale

doi:10.1016/0006-8993(90)90632-l

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…This could possibly be attributable to a higher body temperature. To our knowledge, absolute measurements of body temperature in LE and DI rats are not available, but VP is known to play a role in the control of basal body temperature (46)(47)(48) and to be antipyretic (49)(50)(51). Moreover, heat dissipation is impaired in humans with DI (52).…”

Section: Discussionmentioning

confidence: 99%

Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats

Bardoux

Martin

Ahloulay

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

127

108

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Diabetic nephropathy represents a major complication of diabetes mellitus (DM), and the origin of this complication is poorly understood. Vasopressin (VP), which is elevated in type I and type II DM, has been shown to increase glomerular filtration rate in normal rats and to contribute to progression of chronic renal failure in 5͞6 nephrectomized rats. The present study was thus designed to evaluate whether VP contributes to the renal disorders of DM. Renal function was compared in Brattleboro rats with diabetes insipidus (DI) lacking VP and in normal Long-Evans (LE) rats, with or without streptozotocin-induced DM. Blood and urine were collected after 2 and 4 weeks of DM, and creatinine clearance, urinary glucose and albumin excretion, and kidney weight were measured. Plasma glucose increased 3-fold in DM rats of both strains, but glucose excretion was Ϸ40% lower in DI-DM than in LE-DM, suggesting less intense metabolic disorders. Creatinine clearance increased significantly in LE-DM (P < 0.01) but failed to increase in DI-DM. Urinary albumin excretion more than doubled in LE-DM but rose by only 34% in DI-DM rats (P < 0.05). Kidney hypertrophy was also less intense in DI-DM than in LE-DM (P < 0.001). These results suggest that VP plays a critical role in diabetic hyperfiltration and albuminuria induced by DM. This hormone thus seems to be an additional risk factor for diabetic nephropathy and, thus, a potential target for prevention and͞or therapeutic intervention.One of the major complications of diabetes mellitus (DM) is a progressive nephropathy that develops in about one-third of patients within 10-20 years after the onset of the disease and leads in most cases to end stage renal failure (1). This represents a major problem of public health because a large fraction of dialysis requirements is attributable to DM nephropathy. Although a number of studies have already been devoted to this problem, the factors contributing to diabetic nephropathy are not yet fully identified.A characteristic feature observed in diabetic patients is an elevation of plasma vasopressin (VP), well documented in both type I and type II DM (2-5). This elevation also occurs in animal models of DM, whether experimental or genetically determined (6, 7). Several studies have investigated the possible factors responsible for this increase in VP secretion (3,6,8,9). But they did not succeed in identifying the responsible stimulus for this increase. They revealed a resetting of the osmostat in diabetics but concluded that hyperglycemia was not responsible for this resetting because increasing plasma glucose and osmolality by intravenous infusion of hypertonic dextrose produced no increase in plasma vasopressin in diabetics or in healthy controls (8).Little attention has been given to the possible functional consequences of the rise in plasma VP. To our knowledge, the possible contribution of VP to the renal complications of DM has never been investigated in spite of several previous findings suggesting that this hormone represents a ...

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Section: Discussionmentioning

confidence: 99%

Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats

Bardoux

Martin

Ahloulay

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

127

108

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“…Many peptide hormones have found use as therapeutic agents such as, for example, arginine vasopressin, − oxytocin, − luteinizing hormone, − adrenocorticotropic hormone, − calcitonin, − and somatostatin (Chart ). − Analogs of these peptides have been developed to subdue certain limitations of the naturally occurring peptides, such as the stability against proteases and the binding to receptors, to ultimately improve drug action. These analogs often contain d -amino acids.…”

Section: Introductionmentioning

confidence: 99%

Effect of Conformation on the Photodegradation of Trp- And Cystine-Containing Cyclic Peptides: Octreotide and Somatostatin

Mozziconacci

Schöneich

2014

Mol. Pharmaceutics

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The synthetic cyclic octapeptide octreotide is less stable under UV and fluorescent lights than its naturally occurring derivative somatostatin. Upon irradiation at λ > 290 nm, and in the presence of oxygen, octreotide is quickly transformed into a photoproduct showing an increase of mass of 16 Da. The increase of 16 Da to the mass of octreotide is related to a complex transformation where (i) the side chain of d-Trp is transferred onto the side chain of the Lys residue and (ii) the former d-Trp residue is transformed into hydroxyglycine, which ultimately fragments. The complex sequence of phototransformation is orchestrated by the presence of d-Trp and the unusual orientation of its carbonyl group toward the disulfide bond. The phototransformation of octreotide is illustrated by product A.

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Evidence for Roles of Brain Peptides in Thermoregulation

Clark

Fregly

1996

Comprehensive Physiology

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The effectiveness of arginine vasopressin and sodium salicylate as antipyretics in the Brattleboro rat

Cited by 5 publications

References 28 publications

Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats

Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats

Effect of Conformation on the Photodegradation of Trp- And Cystine-Containing Cyclic Peptides: Octreotide and Somatostatin

Evidence for Roles of Brain Peptides in Thermoregulation

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