Evidence for Roles of Brain Peptides in Thermoregulation

Clark, William G.; Fregly, Melvin J.

doi:10.1002/cphy.cp040108

Cited by 6 publications

(2 citation statements)

References 148 publications

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“…The fact that no consensus has emerged on the possible hypothalamic function of norepinephrine and 5hydroxytryptamine is considered one of the reasons why the effects of amines as analytical tools have taken second place to neuropeptides, for example (Clark and Fregly 1996). Studying the influences of not only neuropeptides but also pyrogens and drugs on thermoregulation has increasingly clarified their importance as modulators of temperature regulation as a whole or of single thermoregulatory effectors.…”

Section: Multimodality Of Locally Thermosensitive Neuronsmentioning

confidence: 99%

The enigma of deep-body thermosensory specificity

Simón¹

2000

International Journal of Biometeorology

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Information provided by the analysis of peripheral cold and warm receptors may be considered a useful guide for assessing the specificity of thermal information originating in deep-body tissues. A wealth of data concerning the location of deep-body thermosensors and their neuronal correlates and modes of transduction permits the following theses to be proposed. 1. Unlike the peripheral warm and cold receptors, deep-body thermosensors are only in part represented by afferent fibers, mostly warm sensitive ones that are not characterized in detail, as the source of thermal information outside the central nervous system (CNS). The more important thermal information generated in the CNS originates mainly from warm-sensitive neurons but contributions of cold-sensitive neurons are not definitely excluded. 2. Unlike the peripheral thermoreceptors, monomodality with respect to natural physical stimuli does not seem to be an essential property of deep-body thermosensors. By contrast, multimodality may underlie at least some of the multitude of interactions between thermoregulatory and other homeostatic control systems. 3. Temperature transduction seems to utilize molecular mechanisms that are also found in neurons that lack any thermosensory functions, and so the transduction mechanisms identified in warm-sensitive CNS neurons do not seem to be specific per se. 4. The observation of a multitude of temperature/response characteristics for thermosensitive CNS neurons has been helpful for categorizing these neurons, but there is no clear information that any one might be particularly relevant. 5. Originating from the peripheral cold and warm receptors two separate but interacting cold- and warm-signal pathways ascend multisynaptically to the hypothalamus as the highest level of thermoregulatory control, and to some extent go further to the sensory cortex. The signal contributed by a deep-body thermosensitive neuron, irrespective of its location, attains specificity by being fed properly into one of the two ascending thermosensory pathways.

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Section: Multimodality Of Locally Thermosensitive Neuronsmentioning

confidence: 99%

The enigma of deep-body thermosensory specificity

Simón¹

2000

International Journal of Biometeorology

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“…Concentrations of cortisol, 26 prolactin 27 and beta-endorphin 28 at rest appeared to be elevated in pregnancy. 28 Because beta-endorphin concentrations do increase during hypothermia, 29 the authors speculated that water temperature rather than exercise per se might have increased beta-endorphin concentrations in their experiments. 28 Because beta-endorphin concentrations do increase during hypothermia, 29 the authors speculated that water temperature rather than exercise per se might have increased beta-endorphin concentrations in their experiments.…”

Section: Cycling In Watermentioning

confidence: 99%

Swimming and diving by pregnant women

Lotgering

Spinnewijn

Wallenburg

1996

Fet. Matern. Med. Rev.

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Pregnant women have traditionally been discouraged from participating in physically demanding sports because they have been considered to be in poor condition and it was thought that strenuous exercise could harm the mother and the fetus. More recently, however, many physically active women have wished to continue sport in pregnancy and research over the past 20 years has shown that in general it is safe to do so.

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