Role of nociceptin/orphanin FQ in thermoregulation

Baiula, Monica; Bedini, Andrea; Spampinato, Santi

doi:10.1016/j.npep.2015.03.005

Cited by 12 publications

(5 citation statements)

References 77 publications

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“…The contribution of -arrestin 2 to NOPr activation and internalization has been reported [23,24]. Future studies are necessary for further investigation of any relationship between NOPr-and TLR4-promoted -…”

Section: -Arrestin 2 Contributes To the Cross-talk Between Nopr And ...mentioning

confidence: 95%

“…The role played by NOPr has been poorly explored in glioblastoma proliferation and signaling. The endogenous ligand nociceptin, also known as orphanin FQ (N/OFQ), is a heptadecapeptide that shares sequence homology with the opioid peptide dynorphin but displays a very low potency in binding to the classical opioid receptors and has a distinct pharmacological profile [23,24]. The binding of N/OFQ to NOPr influences glial cell functions and may counteract the production of proinflammatory cellular events [25] whereas it is up regulated by inflammatory mediators in astrocytes [26].…”

Section: When Citing Please Refer To the Published Versionmentioning

confidence: 99%

See 1 more Smart Citation

Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells

Bedini

Baiula

Vincelli

et al. 2017

Biochemical Pharmacology

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Section: -Arrestin 2 Contributes To the Cross-talk Between Nopr And ...mentioning

confidence: 95%

Section: When Citing Please Refer To the Published Versionmentioning

confidence: 99%

Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells

Bedini

Baiula

Vincelli

et al. 2017

Biochemical Pharmacology

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“…This effect was attributed to the ability of the peptide to modulate the activity of warm-sensitive neurons in the preoptic area of the anterior hypothalamus [ 220 ]. Considering the concomitant stimulation of consummatory behavior and the decrease in body temperature it was suggested that N/OFQ act as an “anabolic” neuropeptide regulates energy balance [ 221 ].…”

Section: Role Of the N/ofq-nop System In The Regulation Of Feeding And Food-related Disordersmentioning

confidence: 99%

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Ubaldi

Cannella

Borruto

et al. 2021

IJMS

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Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, opioid neuropeptides do not activate the NOP receptor. Generally, activation of N/OFQ system exerts anti-opioids effects, for instance toward opioid-induced reward and analgesia. The NOP receptor is widely expressed throughout the brain, whereas N/OFQ localization is confined to brain nuclei that are involved in stress response such as amygdala, BNST and hypothalamus. Decades of studies have delineated the biological role of this system demonstrating its involvement in significant physiological processes such as pain, learning and memory, anxiety, depression, feeding, drug and alcohol dependence. This review discusses the role of this peptidergic system in the modulation of stress and stress-associated psychiatric disorders in particular drug addiction, mood, anxiety and food-related associated-disorders. Emerging preclinical evidence suggests that both NOP agonists and antagonists may represent a effective therapeutic approaches for substances use disorder. Moreover, the current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety.

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“…Dexmedetomidine (DEX) is a highly selective α-2 receptor agonist used to reduce the shivering threshold and has proven to have a better anti-shivering effect than meperidine 9–11. A meta-analysis by Hoffman et al12 revealed that intravenous (IV) DEX was not an optimal choice against PAS because of cardiovascular adverse effects.…”

Section: Introductionmentioning

confidence: 99%

<p>Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review</p>

Jiang

Lin

et al. 2019

DDDT

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BackgroundPost-anesthetic shivering incurs discomfort to patients or even exacerbates their condition. However, no ideal drug has been well established for preventing post-anesthetic shivering. Currently, subarachnoid and epidural dexmedetomidine have demonstrated to have an anti-shivering effect.MethodsAn electronic search was conducted to identify randomized placebo-controlled trials reporting shivering and then compared subarachnoid and epidural dexmedetomidine with placebo in adults undergoing selective surgery. Data assessment and pooling were analyzed by Review Manager 5.3, STATA 15.0 and GRADE-pro 3.6 software.ResultsTwenty-two studies (1389 patients) were subjected to this meta-analysis. The incidence of post-anesthetic shivering decreased from 20.10% in the placebo group to 10.30% in the dexmedetomidine group (RR, 0.48; 95% CI, 0.39–0.59; Z=6.86, P<0.00001, I2=32%). Non-Indian, epidural-space route and cesarean subgroups indicated a better anti-shivering effect. In the subarachnoid-space route subgroup, a dosage of >5 μg showed significantly superior anti-shivering effects than that of ≤5 μg. Subarachnoid and epidural dexmedetomidine increased the incidence of bradycardia, had no impact on nausea and vomiting, shortened the onset of block and lengthened the duration of block and analgesia. However, its effect on hypotension and sedation remained uncertain. The overall risk of bias was relatively low. The level of evidence was high, and the recommendation of voting results was strong.ConclusionDexmedetomidine as a subarachnoid and epidural adjunct drug could decrease the incidence of post-anesthetic shivering in a dose-dependent manner. However, caution should be taken in patients with original bradycardia.

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Role of nociceptin/orphanin FQ in thermoregulation

Cited by 12 publications

References 77 publications

Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells

Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

<p>Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review</p>

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