The effectively specific recognition of bovine serum albumin imprinted silica nanoparticles by utilizing a macromolecularly functional monomer to stabilize and imprint template

Qian, Liwei; Hu, Xiaoling; Guan, Ping; Wang, Dan; Li, Ji; Du, Chunbao; Song, Renyuan; Wang, Chaoli; Song, Wei

doi:10.1016/j.aca.2015.05.015

Cited by 45 publications

(26 citation statements)

References 36 publications

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“…Thus, polymerizable ionic liquids are an important class of monomers for imprinting these aqueous-soluble targets. A few examples of molecularly imprinted polymers using non-crosslinking IL monomers have been published [44][45][46][47][48][49], and a nice example has been recently published using macromolecularly functionalized imidazole monomers [50]; however, there have not been any reports of chiral recognition using imprinted ionic liquids. Thus, a chiral template was imprinted for this purpose using crosslinking ILs developed by the groups of Gin and Noble that uniquely provide the necessary components to form nanoGUMBOS and simultaneously afford for the crosslinking required in the molecular imprinting process.…”

Section: Discussionmentioning

confidence: 99%

Ionic liquid crosslinkers for chiral imprinted nanoGUMBOS

Hamdan

Moore

LeJeune

et al. 2016

Journal of Colloid and Interface Science

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Molecularly imprinted polymers (MIPs) are an important class of selective materials for molecular specific sensors and separations. Molecular imprinting using non-covalent interactions in aqueous conditions still remains a difficult challenge due to interruption of hydrogen-bonding or electrostatic interactions water. Newly developed crosslinking ionic liquids are demonstrated herein to overcome problems of synthesizing aqueous MIPs, adding to previous examples of ionic liquids used as monomers in non-aqueous conditions or used as MIP solvents. Vinylimidazole ionic liquid crosslinkers were synthesized and subsequently explored as matrix supports for fabrication of molecularly imprinted polymeric nanoGUMBOS (nanoparticles derived from a group of uniform materials based on organic salts). Each of the four crosslinkers incorporated a unique functional spacer between the vinylimidazole groups, and the performance of the corresponding molecularly imprinted polymers was evaluated using chiral recognition as the diagnostic. High uptake values for l-tryptophan were found in the 13-87μmol/g range; and chiral recognition was determined via binding ratios of l-tryptophan over d-tryptophan that ranged from 5:1 to 13:1 for polymers made using different crosslinkers. Not only are these materials good for chiral recognition, but the results highlight the utility of these materials for imprinting aqueous templates such as biological targets for theranostic agents.

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Section: Discussionmentioning

confidence: 99%

Ionic liquid crosslinkers for chiral imprinted nanoGUMBOS

Hamdan

Moore

LeJeune

et al. 2016

Journal of Colloid and Interface Science

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“…The structural stability of the template is one of the most critical issues during the synthesis of macromolecules MIPs. In this sense, a new approach to minimize this inconvenience using macromolecular functional monomers for the imprinting of macromolecules, such as proteins, was proposed [ 84 ]. The structural stability of the template is preserved, due to the interaction of the macromolecularly functional monomers with the protein surface, instead of disturbing the hydrogen bonds that sustain the structural stability of the protein.…”

Section: Analytical Applications Of Mip Nanoparticlesmentioning

confidence: 99%

Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

2020

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In recent years, molecularly imprinted polymers (MIPs) have become an excellent solution to the selective and sensitive determination of target molecules in complex matrices where other similar and relative structural compounds could coexist. Although MIPs show the inherent properties of the polymers, including stability, robustness, and easy/cheap synthesis, some of their characteristics can be enhanced, or new functionalities can be obtained when nanoparticles are incorporated in their polymeric structure. The great variety of nanoparticles available significantly increase the possibility of finding the adequate design of nanostructured MIP for each analytical problem. Moreover, different structures (i.e., monolithic solids or MIPs micro/nanoparticles) can be produced depending on the used synthesis approach. This review aims to summarize and describe the most recent and innovative strategies since 2015, based on the combination of MIPs with nanoparticles. The role of the nanoparticles in the polymerization, as well as in the imprinting and adsorption efficiency, is also discussed through the review.

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“…Many commonly used functional monomers have disadvantages to maintain protein conformation, and protein structure will be changed in the process of preparation of molecularly imprinted polymer . Therefore, recognizable cavities on the imprinted polymers are not precisely complementary to the target protein in terms of the shape and the distribution of functional groups.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Anti‐Nonspecific Adsorption Chitosan‐Based Bovine Serum Albumin Imprinted Polymers with Outstanding Adsorption Capacity and Selective Recognition Ability Based on Magnetic Microspheres

Wang

Zhou

et al. 2019

Macro Materials & Eng

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Bovine serum albumin (BSA)-imprinted magnetic microspheres are successfully fabricated by a precipitation copolymerization, in which 2-hydroxyethyl acrylate (HEA) and water-soluble chitosan separately work as functional monomers and cross-linking agents. Hydroxyl derived from HEA as well as hydroxyl, amino, and carboxyl groups, originating from chitosan on the surface of the prepared imprinted microspheres, can form hydrogen bonds and extra electrostatic interaction with proteins. The sulfobetaine methacrylate (SBMA) is introduced into the imprinted polymer as an anti-protein segment to reduce the nonspecific adsorption and improve the selectivity. Detailed characterization demonstrates that the imprinted layer is about 10 nm, which is extremely beneficial for BSA identification and quality transmission. Furthermore, these microspheres also display an excellent selective adsorption of BSA (IF = 5.0). The results reveal that the prepared imprinted materials can be used as BSA biosensor or separation materials.

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The effectively specific recognition of bovine serum albumin imprinted silica nanoparticles by utilizing a macromolecularly functional monomer to stabilize and imprint template

Cited by 45 publications

References 36 publications

Ionic liquid crosslinkers for chiral imprinted nanoGUMBOS

Ionic liquid crosslinkers for chiral imprinted nanoGUMBOS

Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

Preparation of Anti‐Nonspecific Adsorption Chitosan‐Based Bovine Serum Albumin Imprinted Polymers with Outstanding Adsorption Capacity and Selective Recognition Ability Based on Magnetic Microspheres

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