The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

Clement, Michele; Hehir, Maureen; Phillips, Harriett; Vivier, Anthony du

doi:10.1111/j.1365-2133.1983.tb03549.x

Cited by 10 publications

(1 citation statement)

References 13 publications

(8 reference statements)

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“…Subsequent studies examined steroid suppressive effects on normal epidermal DNA synthesis in the hairless mouse (Clement t7 al., 1983). Other aspects of topical steroid pharmacology have also been examined, including treatment frequency, tachyphylaxis and steroid/tar, steroid/ anthralin combinations (Clement et al, 1983).…”

Section: Topical Steroid and The Suppression Of Epidermal Dna Synthesismentioning

confidence: 99%

Animal assays for anti-psoriatic., retinoid and sunprotective agents

et al. 1984

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It is possible to evaluate different dermatological therapeutic agents intended for human use in a variety of animal assays. This review will discuss some of these assays, and attempt to correlate animal and human skin responses. Psoriasis is a disease where changes in epidermal proliferation may be an important factor. It is possible to assay potential anti-psoriatic agents by measuring their ability to suppress DNA synthesis in the epidermis of hairless mice. This assay is predictive of the anti-psoriatic effectiveness of numerous agents including a variety of anti-proliferative drugs and anthralin, and has been used to evaluate the potential efficacy of purified coal tar shampoos and body preparations. The activity of the polyamine biosynthesis enzyme ornithine decarboxylase (ODC) is elevated in psoriatic skin, and it is induced in mouse epidermis by tape stripping. Retinoids can inhibit the induction of ODC activity, and this inhibition may be used to evaluate novel synthetic retinoids. Retinoids have beneficial effects on the abnormal keratinization found in various diseases. Rhino mice have multiple keratin-filled epidermal utricles, and the size of these is reduced by retinoid treatment. Observing the changes in the size of the utricles can be utilized to evaluate the effects of retinoids on keratinization. Sunscreen agents are tested on human volunteers by observing their ability to inhibit the erythema induced by exposure to solar-simulated light, to obtain a sun protection factor (SPF). It is possible to utilize the ability of sunscreens to inhibit other actinic-induced changes in the skin using animals. Parameters that may be measured include changes in DNA synthesis and ODC activity in the epidermis following ultraviolet irradiation. Some of these assays correlate well with human SPF determinations.

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Section: Topical Steroid and The Suppression Of Epidermal Dna Synthesismentioning

confidence: 99%

Animal assays for anti-psoriatic., retinoid and sunprotective agents

et al. 1984

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Anthralin-Corticosteroid Combination Therapy in the Treatment of Chronic Plaque Psoriasis

Monk

Hehir²,

Clement³

et al. 1988

Arch Dermatol

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A prospective randomized trial of anthralin in Lassar's paste compared with anthralin in 0.0125% clobetasol propionate in the treatment of chronic plaque psoriasis was undertaken. The psoriatic skin of patients treated with the corticosteroid-anthralin combination cleared significantly more quickly than those treated with anthralin alone, with a mean time to clearance of 14.9 days compared with 18.5 days, and with lower concentrations of anthralin. No significant difference was found in the rate of relapse of the two treatment groups, with relapse occurring in over 80% of patients within one year. Anthralin in 0.0125% clobetasol propionate was found to be an effective agent in the treatment of chronic plaque psoriasis, and one that was cosmetically acceptable to patients and nursing staff. An important disadvantage, however, was the development of a staphylococcal folliculitis in four of the 35 patients in which it was used. Because of this, anthralin in Lassar's paste remains our standard inpatient therapy, although the ease of use and cosmetic acceptability of anthralin in clobetasol propionate make it a useful remedy for outpatient use.

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Endocrinology1

Vogel

Schölkens

et al. 2002

Drug Discovery and Evaluation

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The effect on epidermal DNA synthesis of a combination of topical steroid with either dithranol or tar as used for psoriasis

Cited by 10 publications

References 13 publications

Animal assays for anti-psoriatic., retinoid and sunprotective agents

Animal assays for anti-psoriatic., retinoid and sunprotective agents

Anthralin-Corticosteroid Combination Therapy in the Treatment of Chronic Plaque Psoriasis

Endocrinology1

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