1988
DOI: 10.1001/archderm.1988.01670040050021
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Anthralin-Corticosteroid Combination Therapy in the Treatment of Chronic Plaque Psoriasis

Abstract: A prospective randomized trial of anthralin in Lassar's paste compared with anthralin in 0.0125% clobetasol propionate in the treatment of chronic plaque psoriasis was undertaken. The psoriatic skin of patients treated with the corticosteroid-anthralin combination cleared significantly more quickly than those treated with anthralin alone, with a mean time to clearance of 14.9 days compared with 18.5 days, and with lower concentrations of anthralin. No significant difference was found in the rate of relapse of … Show more

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Cited by 16 publications
(9 citation statements)
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“…In 1970, Farber and Harris 4 first reported the benefits of a modified dithranol regimen, alternating daily topical corticosteroid application with nightly low‐strength dithranol paste, with complete clearance within an mean treatment period of 11 days. More recently, Monk et al 5 . found a significantly faster clearance and no significant difference in relapse rate using dithranol in 0·0125% clobetasol propionate, compared with dithranol in Lassar's paste, in the treatment of chronic plaque psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…In 1970, Farber and Harris 4 first reported the benefits of a modified dithranol regimen, alternating daily topical corticosteroid application with nightly low‐strength dithranol paste, with complete clearance within an mean treatment period of 11 days. More recently, Monk et al 5 . found a significantly faster clearance and no significant difference in relapse rate using dithranol in 0·0125% clobetasol propionate, compared with dithranol in Lassar's paste, in the treatment of chronic plaque psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…No significant difference was found in the rate of relapse (80% within one year) of the two treatment groups. 63 In a Norvegian randomised, double-blind study right-versus left-side comparison of two different ointments, CP and calcipotriol 50 microg/g bd, was carried out. The ointments were applied to two simmetrically-located areas for two weeks followed by a 4-weeks period of calcipotriol in 49 psoriasis patients.…”
Section: 52mentioning
confidence: 99%
“…In particular, the combination with ultraviolet B treatment and, to a lesser degree, topical corticosteroids, are time‐honoured principles. However, well‐designed placebo‐controlled, prospective studies of these combination treatments are sparse with recent studies suggesting that these combinations have little therapeutic value 72–77 …”
Section: Calcineurin Inhibitorsmentioning
confidence: 99%