The effect of β-sitosterol on the metabolism of cholesterol and lipids in rats on a diet containing coconut oil

Gerson, T.; Shorland, F. B.; Dunckley, G.G.

doi:10.1042/bj0960399

Cited by 30 publications

(10 citation statements)

References 8 publications

(18 reference statements)

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“…On the other hand, it has been reported that the intraperitoneal administration of iS sitosterol causes the decrease of cholesterol content in the blood and liver, and the mechanism of its hypocholesterolemic effect is due to the acceleration of cholesterol oxidation in the liver (8). In the present study, the intravenous administrations of OZ and CAF caused a significant inhibition of the hyperlipidemia in comparison with the oral administration groups.…”

Section: Discussionsupporting

confidence: 52%

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Effects of .GAMMA.-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats.

et al. 1987

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Abstract-Hypolipidemic effects of r-oryzanol (OZ) and cycloartenol ferulic acid ester (CAF) on the hyperlipidemia induced by ingestion of a high cholesterol diet (HCD) in male Sprague-Dawley rats were investigated. The test drugs were given orally and intravenously, daily for 12 days with the HCD feeding. The oral administration with OZ and CAF at 100 mg/kg daily for 6 or 12 days did not ap parently prevent the hyperlipidemia induced by HCD-feeding. The intravenous administrations with OZ and CAF at 10 mg/kg for 6 days significantly inhibited the increases in serum total cholesterol (TC), phospholipid (PL) and free cholesterol by HCD. OZ and CAF did not inhibit the decreases of TC in high density lipoprotein (HDL-TC) and HDL-PL by HCD. The increases of atherogenic index ([TC-HDL TC]/[HDL-TC] and [PL-HDL-PL]/[HDL-PL]) with the HCD feeding were reducedby the intravenous administrations of OZ and CAF. Triglyceride , nonesterified fatty acid, lactate dehydrogenase and transaminase (GOT and GPT) markedly decreased below the control level by the intravenous administrations of OZ and CAF for 12 days. These results suggest that the intravenous administrations of OZ and CAF may have accelerated the excretion of lipids in the blood.The hypolipidemic effect of the usual type of r-oryzanol has been reported by some workers (1-5). The usual type of r-oryzanol is a ferulic acid ester of cycloartenol, 24 methylene cycloartenol, cyclobranol and other sterols. We have previously reported the hypolipidemic effect of the usual type of r-oryzanol as compared to the effect of r oryzanol (OZ) with a sterol composition different from that of the usual type in high cholesterol diet (HCD)-fed rats (6). The inhibition of total cholesterol (TC) increase by the administration of OZ was weaker than that of the usual r-oryzanol, but the inhibition of free cholesterol (FC) and triglyceride (TG) increases and increase of TC in high density lipoprotein (HDL-TC) by OZ were more potent than those of the usual r oryzanol, and it may be due to the concen tration of cycloartenol as an inclusive ratio of sterols (6). The present study was designed to test this hypothesis, and the effects of cycloartenol ferulic acid ester (CAF) were compared with OZ.On the other hand, the intestinal absorp tion of vegetable sterols such as soysterol are markedly lower; therefore, it has been considered that the hypolipidemic mechanism of these sterols was the inhibition of lipid absorption in the intestine (7). Moreover , Gerson et al. (8) have reported that the intraperitoneal administration of Q-sitosterol (type of vegetable sterols) increased the lipid excretion from the blood. OZ and CAF , which are types of vegetable sterols, may have the similar effects to Q-sitosterol on the lipid metabolism. Therefore, the hypolipidemic effects of the intravenous administration of OZ or CAF on the HCD induced hyper lipidemia in rats were investigated.

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Section: Discussionsupporting

confidence: 52%

“…Moreover , Gerson et al (8) have reported that the intraperitoneal administration of Q-sitosterol (type of vegetable sterols) increased the lipid excretion from the blood. OZ and CAF , which are types of vegetable sterols, may have the similar effects to Q-sitosterol on the lipid metabolism.…”

mentioning

confidence: 99%

Effects of .GAMMA.-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats.

et al. 1987

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“…The decrease o f liver fatty acids content reflects a decrease o f liver lipid content, which has already been described after intraperito neal injection o f (3-sitosterol [13].…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that, among complex phenomena, the inhibition o f cholesterol ab sorption by phytosterols is most important [8][9][10], In previous papers [8,11], we re ported the effects of dietary phytosterols on plasma lipids o f Wistar rats and suggested with others [ 12] the effects o f phytosterols on cholesterol synthesis. A previous study by Gerson et al [13] using l4C-labeled molecules …”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Phytosterols on Liver Lipids and Lipid Metabolism Enzymes

et al. 1993

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The effects of dietary phytosterols on lipid metabolism have been assessed through determination of liver lipids (sterols and fatty acids) and lipid metabolism enzymes (acetyl-CoA carboxylase, malic enzyme, glucose-6-phosphate dehydrogenase) in rats fed 12 or 24 mg cholesterol a day and 0-96 mg phytosterols. The results indicate that, provided the dietary phytosterol to cholesterol ratio is at least 1 and in the presence of a dietary cholesterol excess, phytosterols do exert a regulatory role through decreases of both acetyl-CoA carboxylase and malic enzyme activities. A ratio of 2 enhances this effect. At the same time, liver fatty acids and cholesterol contents significantly decrease.

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“…Hence, the pharmaceutical use of plant sterols has been proposed due to their potency in lowering blood cholesterol levels without causing harmful side-effects even when administered in large doses (Gerson et al, 1965).…”

Section: Resultsmentioning

confidence: 99%

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

Sim¹,

Bragg²

1977

Poultry Science

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Effects of dietary lipid factors (saturated and unsaturated oil, cholesterol and plant sterols) on the serum and egg yolk cholesterol levels of the laying hen were investigated. Single Comb White Leghorn laying hens, at thirty weeks of age, were used in two trials by feeding two basal diets containing 8.0% hydrogenated coconut oil or safflower oil, with or without supplemental cholesterol (1.0%), soysterols (2.0%) or combinations of both. Safflower oil, per se, had a superior property to hydrogenated coconut oil in suppressing cholesterol levels, in both serum and egg yolk. Cholesterol supplementation to the safflower oil basal diet resulted in a significant (P less than 0.01) elevation of serum and egg yolk cholesterol levels, whereas cholesterol in combination with hydrogenated coconut oil did not change the serum level. Cholesterol lowering effect of soysterols was clearly demonstrated in both serum and egg yolk by feeding soysterols alone as well as by feeding soysterols in combination with cholesterol.

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The effect of β-sitosterol on the metabolism of cholesterol and lipids in rats on a diet containing coconut oil

Cited by 30 publications

References 8 publications

Effects of .GAMMA.-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats.

Effects of .GAMMA.-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats.

Effects of Dietary Phytosterols on Liver Lipids and Lipid Metabolism Enzymes

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

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