The effect of β-sitosterol on the metabolism of cholesterol and lipids in rats on a diet low in fat

Gerson, T.; Shorland, F. B.; Dunckley, G.G.

doi:10.1042/bj0920385

Cited by 36 publications

(22 citation statements)

References 9 publications

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“…However, evidence shown in both Trial 1 and Trial 2, does not reveal that the simultaneous presence of soysterol and cholesterol in the diet is mandatory in order to achieve the anti-cholesterogenic effect in laying hens. These results suggest that the functional site of plant sterols in regulating cholesterol metabolism is not exclusively located at the absorption site as indicated by other reports (Gerson et al, 1964;Konlande and Fisher, 1969;and Zilletti, 1970). In fact, the experimental evidence indicates that cholesterol and plant sterol was absorbed independently by both intestinal mucosa in vivo, and intestinal slice in vitro (Borgstrom 1967(Borgstrom , 1968and Sylbein and Borgstorm, 1969).…”

Section: Resultssupporting

confidence: 54%

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

Sim¹,

Bragg²

1977

Poultry Science

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Effects of dietary lipid factors (saturated and unsaturated oil, cholesterol and plant sterols) on the serum and egg yolk cholesterol levels of the laying hen were investigated. Single Comb White Leghorn laying hens, at thirty weeks of age, were used in two trials by feeding two basal diets containing 8.0% hydrogenated coconut oil or safflower oil, with or without supplemental cholesterol (1.0%), soysterols (2.0%) or combinations of both. Safflower oil, per se, had a superior property to hydrogenated coconut oil in suppressing cholesterol levels, in both serum and egg yolk. Cholesterol supplementation to the safflower oil basal diet resulted in a significant (P less than 0.01) elevation of serum and egg yolk cholesterol levels, whereas cholesterol in combination with hydrogenated coconut oil did not change the serum level. Cholesterol lowering effect of soysterols was clearly demonstrated in both serum and egg yolk by feeding soysterols alone as well as by feeding soysterols in combination with cholesterol.

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Section: Resultssupporting

confidence: 54%

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

Sim¹,

Bragg²

1977

Poultry Science

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“…Tall oil phytosterols are rich in sitostanol, which is not absorbed (Heinemann et al 1988(Heinemann et al , 1991Vanhanen and Miettinen 1992), while SB phytosterols are abundant in DHB. An intrinsic effect of absorbed phytosterols was suggested in two studies (Gerson et al 1964;Konlande and Fisher 1969;Malini and Vanithakumari 1990). Intraperitoneal and intravenous injections of high levels of β-sitosterol decreased cholesterol-7-alpha-hydroxylase activity (Boberg et al 1989;Shefer et al 1994) which affects cholesterol homeostasis.…”

Section: Tissue Phytosterol Analysismentioning

confidence: 97%

“…It has been suggested that phytosterols reduce plasma cholesterol levels by mainly inhibiting cholesterol absorption from the intestinal lumen (Shidoji et al 1980;Ikeda and Sugano 1983;Heinemann et al 1988;Miettinen and Vanhanen 1994). Nonetheless, the effect of phytosterols on cholesterogenesis remains controversial, as studies have shown that β-sitosterol lowers plasma cholesterol levels while simultaneously either stimulating (Gerson et al 1964;Konlande and Fisher 1969) or inhibiting (Kakis and Kuksis 1984) cholesterol synthesis.…”

mentioning

confidence: 94%

Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters

Ntanios¹,

MacDougall²,

Jones³

1998

Can. J. Physiol. Pharmacol.

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To examine the effect of gender on the mechanisms of action of phytosterols extracted from tall oil (TO) and soybean (SB) on cholesterol and phytosterol metabolism, male and female hamsters were fed cholesterol-enriched diets containing 0.5 or 1% (w/w) TO or SB phytosterols for 90 days. Plasma lipoprotein cholesterol profile and tissue phytosterol and cholesterol biosynthesis levels were determined. Mean plasma total-cholesterol level in females fed 1% (w/w) SB was reduced (p<0.05) by 44%, while in males it was lowered (p<0.05) by 25% compared with their respective controls. Moreover, mean plasma total-cholesterol level was reduced (p<0.05) in male hamsters by -31% and female hamsters by -32% when fed 1% (w/w) TO. Cholesterol biosynthesis was higher (p<0.05) by twofold in groups fed TO at 0.5 and 1% (w/w) concentrations, compared with SB. Hamsters fed TO at 0.5 and 1% (w/w) levels also had higher (p<0.05) hepatic and enterocytic campesterol contents than SB-fed animals. These findings demonstrate gender differences in cholesterol metabolism in TO- and SB-fed hamsters. The results suggest that TO, conversely to SB phytosterol, is a more effective cholesterol-lowering agent in male, but not as much in female, hamsters, over a feeding period of 90 days.

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“…Phytosterols have long been known to be hypocholestérolémie in most species o f ani mals [1][2][3][4][5][6][7][8]. Numerous hypotheses deal with this effect.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Phytosterols on Liver Lipids and Lipid Metabolism Enzymes

et al. 1993

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The effects of dietary phytosterols on lipid metabolism have been assessed through determination of liver lipids (sterols and fatty acids) and lipid metabolism enzymes (acetyl-CoA carboxylase, malic enzyme, glucose-6-phosphate dehydrogenase) in rats fed 12 or 24 mg cholesterol a day and 0-96 mg phytosterols. The results indicate that, provided the dietary phytosterol to cholesterol ratio is at least 1 and in the presence of a dietary cholesterol excess, phytosterols do exert a regulatory role through decreases of both acetyl-CoA carboxylase and malic enzyme activities. A ratio of 2 enhances this effect. At the same time, liver fatty acids and cholesterol contents significantly decrease.

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The effect of β-sitosterol on the metabolism of cholesterol and lipids in rats on a diet low in fat

Cited by 36 publications

References 9 publications

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

Effect of Dietary Factors on Serum and Egg Yolk Cholesterol Levels of Laying Hens

Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters

Effects of Dietary Phytosterols on Liver Lipids and Lipid Metabolism Enzymes

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