The effect of β-adrenergic receptor antagonism in cardiac sympathetic neuronal remodeling in patients with heart failure

Chizzola, Paulo Roberto; Freitas, Humberto Felício Gonçalves de; Marinho, Norma Vasconcelos Saldanha; Mansur, José Alfredo; Meneghetti, José Cláudio; Bocchi, Edimar Alcides

doi:10.1016/j.ijcard.2004.12.050

Cited by 27 publications

(13 citation statements)

References 31 publications

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“…Heart failure, the final common pathway of every heart disease, is characterized by exacerbated neurohormonal activity, low tolerance to exercise, short survival time, and poor quality of life [1][2][3] . Quality of life is a discrepancy between the satisfaction or discontent of an individual regarding certain areas of his/her own life according to his/her own perception, and is considered the best indicator of quality of life 4. In conventional terms, satisfaction with life refers to the fulfillment of needs, expectations, longings, and desires 5 .…”

Section: Introductionmentioning

confidence: 99%

Validação da versão em português do Minnesota Living with Heart Failure Questionnaire

Carvalho¹,

Guimarães²,

Carrara³

et al. 2009

Arq. Bras. Cardiol.

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Section: Introductionmentioning

confidence: 99%

Validação da versão em português do Minnesota Living with Heart Failure Questionnaire

Carvalho¹,

Guimarães²,

Carrara³

et al. 2009

Arq. Bras. Cardiol.

Self Cite

132

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“…It is characterized by the persistent activation of the neurohormonal system,4 endothelial dysfunction,5 exercise intolerance,6,7,8,9 high mortality10 and a poor quality of life 11…”

Section: Introductionmentioning

confidence: 99%

Hydrotherapy in Heart Failure: A Case Report

Carvalho

Bocchi

Guimarães

2009

Clinics

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“…Since the first Brazilian study on the effect of beta-blockers on heart failure 13 , few others have been published [14][15][16] . There are no studies evaluating the effects of bisoprolol on cardiac function and exercise capacity of patients with heart failure in Brazilian clinical experience.…”

Section: Introductionmentioning

confidence: 99%

Efeito do bisoprolol sobre a função cardíaca e o exercício em pacientes com insuficiência cardíaca

Issa¹,

Guimarães²,

Rezende³

et al. 2007

Arq. Bras. Cardiol.

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SummaryObjectives: To assess the effects of bisoprolol on exercise capacity and ventricular function in patients with heart failure.Methods: Clinical and hemodynamic variables, ventricular function and remodeling, and ergospirometry of patients with heart failure of different etiologies were evaluated before and after the administration of bisoprolol.Results: Twenty-two patients were analyzed; one patient did not tolerate medication and 14 patients reached the study goal. The group consisted of 9 men and 5 women, the mean age was 52 (36-64) years, and patients were followed during 551 days (238-1109). We observed an improvement in NYHA functional class, reduction in resting heart rate (78.8±8.7 vs 63±6.4 bpm, p <0.001), increase in left ventricular ejection fraction (31.3±8.5% vs 39±14.7%. p=0.043), and a tendency towards improved quality of life scores (31±20.6 vs 17.8±14.8. p=0.058). The maximum heart rate dropped during exercise (138.1±20.2 vs 116.7±27.1. p=0.01), as did peak oxygen consumption (20.9±6.8 vs 15.1±3.5. p<0.001); no change was observed on the EV/VCO2 slope. The effects were observed for all etiologies, including Chagas' disease.Conclusion: Bisoprolol was safe and well tolerated in patients with heart failure. Bisoprolol therapy improved the symptoms, hemodynamic variables, as well as the cardiac function for all etiologies; however, it did not result in improved exercise capacity.

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The effect of β-adrenergic receptor antagonism in cardiac sympathetic neuronal remodeling in patients with heart failure

Cited by 27 publications

References 31 publications

Validação da versão em português do Minnesota Living with Heart Failure Questionnaire

Validação da versão em português do Minnesota Living with Heart Failure Questionnaire

Hydrotherapy in Heart Failure: A Case Report

Efeito do bisoprolol sobre a função cardíaca e o exercício em pacientes com insuficiência cardíaca

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