The effect of Zingiber Officinale Extract on  Preventing Demyelination of Corpus Callosum  in a Rat Model of Multiple Sclerosis

Moradi, Valiollah; Esfandiary, Ebrahim; Ghanadian, Mustafa; Ghasemi, Nazem; Rashidi, Bahman

doi:10.52547/ibj.2979

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…Here, we, for the rst-time report that UA promotes muscular strength in CPZ-challenged animals in the Kondziela's Inverted Screen Test. FTY720 also exerts a bene cial effect against CPZinduced motor dysfunction in animals (Mitra et al, 2022;Moradi et al, 2022). Interestingly, FTY720 exerted anxiolytic activity in the CPZ-induced animal model of MS.…”

Section: Discussionmentioning

confidence: 99%

Ursolic acid attenuates cuprizone-induced alteration in cortical ceramide synthase-2, sphingomyelin synthase-1, and serine palmitoyl transferase-1 expression in rodent model of multiple sclerosis

Babu,

Pancholi,

Prashar

et al. 2024

Preprint

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Ceramide plays an important role in the myelination process; thus, the ceramide biosynthetic pathway could be considered a potential target in managing multiple sclerosis (MS). Fingolimod, an approved drug for MS, is considered a standard modulator of the ceramide biosynthetic pathway in the experimental model of MS. Ursolic acid (UA) exhibited neuroprotective activity in Cuprizone (CPZ)-induced animal model of MS. However, the protective activity of UA is yet to be established in the experimental model of MS. Therefore, the objective of the study was to evaluate the effect of UA (50, 100, and 200 mg/kg; p.o.) on the level of expression of ceramide synthase 2 (CS2), sphingomyelin synthase 1 (SMS1) and serine palmitoyl transferase 1 (SPTLC1) in CPZ-induced animal model of MS. CPZ (6 mg/kg; p.o.) was administered for 30 days once daily to male Swiss Albino mice to induce MS. CPZ significantly caused a decrease in the number of squares crossed in Open field, decrease in the muscular strength in Kondziela’s inverted screen, decrease in the ratio between open to closed arm in elevated plus maze, and decrease in the number of head dip in hole board tests in the animals. Further, CPZ increased the levels of reactive oxygen species, GFAP, and Iba-1 and decreased the levels of MBP, NeuN, and Olig2 in mice cortex. Interestingly, CPZ increased the levels of CS2 and SPTLC1, and decreased the level of SMS1 in mice cortex. UA (100 and 200 mg/kg) significantly attenuated CPZ-induced behavioural, biochemical and molecular parameters in the animals. Thus, UA could be a potential therapeutic alternative in the management of MS. Further, the biomarkers of ceramide biosynthetic pathway such as CS2, SMS1, and SPTLC1 could be potential therapeutic targets in the management of MS.

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Section: Discussionmentioning

confidence: 99%

Ursolic acid attenuates cuprizone-induced alteration in cortical ceramide synthase-2, sphingomyelin synthase-1, and serine palmitoyl transferase-1 expression in rodent model of multiple sclerosis

Babu,

Pancholi,

Prashar

et al. 2024

Preprint

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“…However, it has been shown that ginger extract can prevent demyelination and improve remyelination in the corpus callosum. 42 Moreover, it has been reported that 6-gingerol can induce tolerogenic dendritic cells, promising candidates for the management of autoimmune diseases. 15…”

Section: Discussionmentioning

confidence: 99%

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

et al. 2023

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“…The dosage of ginger extract varies depending on the specific product and the condition being treated. However, most studies have used a dose of 500 mg to 2000 mg of ginger extract per day [51].…”

Section: Gingermentioning

confidence: 99%

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Addissouky,

Ali,

El Tantawy El Sayed

et al. 2023

Arch Pharmacol Ther

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Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers. While the use of antibiotics and PPIs remains the primary treatment approach, there is a growing interest in alternative therapies, including botanical extracts, natural products, and traditional medicines. Recent research has also explored the potential of probiotics, phage therapy, and novel antibiotics, such as rifabutin and furazolidone, in the treatment of H. pylori infection. Recent studies have also explored the potential of artificial intelligence (AI) in the diagnosis and management of H. pylori infection. AI-assisted screening methods have identified novel botanical extracts and natural products with anti-H. pylori activity, providing new avenues for therapeutic development. Additionally, AI can improve diagnostic accuracy and treatment outcomes. Although these alternative approaches show promise, further research is needed to confirm their efficacy, safety, and optimal dosing. Novel therapies such as phage therapy and new antibiotics may provide an alternative to traditional treatments and help overcome antimicrobial resistance.

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The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis

Cited by 3 publications

References 55 publications

Ursolic acid attenuates cuprizone-induced alteration in cortical ceramide synthase-2, sphingomyelin synthase-1, and serine palmitoyl transferase-1 expression in rodent model of multiple sclerosis

Ursolic acid attenuates cuprizone-induced alteration in cortical ceramide synthase-2, sphingomyelin synthase-1, and serine palmitoyl transferase-1 expression in rodent model of multiple sclerosis

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

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